A STEPWISE CONFIDENCE INTERVAL PROCEDURE BASED ON AN ASYMMETRIC LOSS FUNCTION WITH APPLICATIONS TO TOXICOLOGICAL EVALUATION

The purpose of toxicological studies is a safety assessment of compounds (e.g. pesticides, pharmaceuticals, industrial chemicals and food additives) at various dose levels. Because a mistaken declaration that a really non-equivalent dose is equivalent could have dangerous consequences, it is important to adopt reliable statistical methods that can properly control the family-wise error rate. We propose a new stepwise confidence interval procedure for toxicological evaluation based on an asymmetric loss function. The new procedure is shown to be reliable in the sense that the corresponding family-wise error rate is well controlled at or below the pre-specified nominal level. Our simulation results show that the new procedure is to be preferred over the classical confidence interval procedure and the stepwise procedure based on Welch's approximation in terms of practical equivalence/safety. The implementation and significance of the new procedure are illustrated with two real data sets: one from a reproductive toxicological study on Nitrofurazone in Swiss CD-1 mice, and the other from a toxicological study on Aconiazide.     

Likelihood-based approaches for multivariate linear models under inequality constraints for incomplete data

In this paper, we consider a multivariate linear model with complete/incomplete data, where the regression coefficients are subject to a set of linear inequality restrictions. We first develop an expectation/conditional maximization (ECM) algorithm for calculating restricted maximum likelihood estimates of parameters of interest. We then establish the corresponding convergence properties for the proposed ECM algorithm. Applications to growth curve models and linear mixed models are presented. Confidence interval construction via the double-bootstrap method is provided. Some simulation studies are performed and a real example is used to illustrate the proposed methods.     

On the consistency of rank transformed regression

Rank-transformed regression (RTR) was proposed by Iman and Conover (1979) as an alternative to isotonic regression. This paper studies the consistency of the estimate obtained by RTR and show that, in general case, the estimate is not mean-square-error (MSE) consistent. The bias of the estimate is also studied by simulation.     

Statistical inference on difference or ratio of means from heteroscedastic normal populations

In this paper, we propose a two-stage sampling method (Stein, 1945) for making inferences on the means of two normal populations with heteroscedastic variances which is usually referred to as the Behrens–Fisher problem (6 and 7). The two-stage method can be used to control Type-II error and the length of confidence interval conditional on a specified Type-I error or confidence level. Simulation results show that the two-stage method improves the powers of the tests and its performance exhibits superior robustness properties over the existing single-stage methods. Moreover, our method can be easily extended to compare multiple populations.     

On Modelling Agreement and Category Distinguishability on an Ordinal Scale

It is quite common that raters may need to classify a sample of subjects on a categorical scale. Perfect agreement can rarely be observed partly because of different perceptions about the meanings of the category labels between raters and partly because of factors such as intrarater variability. Usually, category indistinguishability occurs between adjacent categories. In this article, we propose a simple log-linear model combining ordinal scale information and category distinguishability between ordinal categories for modelling agreement between two raters. For the proposed model, no score assignment is required to the ordinal categories. An algorithm and statistical properties will be provided.     

Nonparametric Estimation of Bounded Survival Functions with Censored Observations

Stochastic ordering of survival functions is a useful concept in many areas of statistics, especially in nonparametric and order restricted inferences. In this paper we introduce an algorithm to compute maximum likelihood estimates of survival functions where both upper and lower bounds are given. The algorithm allows censored survival data. In a simulation study, we found that the proposed estimates are more efficient than the unrestricted Kaplan-Meier product limit estimates both with and without censored observations.     

S–S method for stochastically ordered multinomial populations with missing data

Stochastic ordering is a useful concept in order restricted inferences. In this paper, we propose a new estimation technique for the parameters in two multinomial populations under stochastic orderings when missing data are present. In comparison with traditional maximum likelihood estimation method, our new method can guarantee the uniqueness of the maximum of the likelihood function. Furthermore, it does not depend on the choice of initial values for the parameters in contrast to the EM algorithm. Finally, we give the asymptotic distributions of the likelihood ratio statistics based on the new estimation method.     

中国经济增长趋势与人均国内生产总值、收人以及消费之间关系的研究：1978-2002

自1978年改革开放以来,中国人均国内生产总值连续高速增长。研究表明:截至2002年,25年来中国人均国内生产总值的增长不是均衡的,而是分阶段的。文章基于对25年来中国人均国内生产总值、人均收入以及人均消费的关系的研究,提出一个更为合适的分段模型———线性误差模型。同时,给出该模型中参数的估计方法。     

A note on the orthant probability of the elliptically contoured distribution

When a scale matrix satisfies certain conditions, the orthant probability of the elliptically contoured distribution with the scale matrix is expressed as the same probability of the equicorrelated normal distribution.     

A Note on the Comparison of the Stein Estimator and the James-Stein Estimator

The seminal work of Stein (1956 Stein, C. (1956). Inadmissibility of the usual estimator for the mean of a multivariate normal distribution. Proc. Third Berkeley Symp. Mathemat. Statist. Probab., University of California Press, 1:197–206. [Google Scholar]) showed that the maximum likelihood estimator (MLE) of the mean vector of a p-dimensional multivariate normal distribution is inadmissible under the squared error loss function when p ? 3 and proposed the Stein estimator that dominates the MLE. Later, James and Stein (1961 James, W., Stein, C. (1961). Estimation with quadratic loss. Proc. Fourth Berkeley Symp. Mathemat. Statist. Probab., University of California Press, 1:361–379. [Google Scholar]) proposed the James-Stein estimator for the same problem and received much more attention than the original Stein estimator. We re-examined the Stein estimator and conducted an analytic comparison with the James-Stein estimator. We found that the Stein estimator outperforms the James-Stein estimator under certain scenarios and derived the sufficient conditions.