Estimating the frequency of familial dilated cardiomyopathy in the presence of misclassification errors

Dilated cardiomyopathy is a disease of unknown cause characterized by dilation and impaired function of one or both ventricles. Most cases are believed to be sporadic, although familial forms have been detected. The familial form has been estimated to have a relative frequency of about 25%. Since, except for familial history, familial form has no other characteristics that could help in classifying the two diseases, the estimate of the frequency of the familial form should take into account a possible misclassification error. In our study, 100 cases were randomly selected in a prospective series of 350 patients. Out of them, 28 index cases were included in the analysis: 12 were known to be familial, and 88 were believed to be sporadic. After extensive clinical examination of the relatives, 3 patients supposed to have a sporadic form were found to have a familial form. 13 cases had a confirmed sporadic disease. Models in the Log-Linear Product class (LLP) have been used to separate classification errors from underlying patterns of disease incidence. The most conservative crude estimate of the misclassification error is 16.1% (CI 0.22- 23.27%), which leads to a crude estimate of the frequency of the familiar form of about 60%. An estimate of the disease frequency, adjusted for taking into consideration the sampling plan, is 40.93% (CI 32.29-44.17%). The results are consistent with the hypothesis that genetic factors are still underestimated, although they represent a major cause of the disease.     

Ownership structure,investors’ protection and corporate valuation: the effect of judicial system efficiency in family and non-family firms

Research on the effect of ownership structure on firm performance shows no convergent evidence concerning the sign and form of the above-mentioned relationship. Similarly, there is no homogeneous evidence documenting family ownership concentration is always positively or negatively correlated with firm value, or irrelevant. This paper analyses whether and how the de facto investor protection provided by the judicial system affects the relationship between corporate performance and ownership structure in 1314 firms operating in four European countries (Germany, France, Italy, and Spain) over a five-year period, 2010–2014. Moreover, we analyse whether judicial system efficiency influences if and how family firms in the controlling coalition collude for expropriating minority shareholders. Our findings show that the level of shareholder protection, derived from judicial efficiency, is relevant to the relationship between ownership structure and firm performance, thus corroborating literature in that institutional contexts matter in explaining such relations. The results suggest the need for more efficient external mechanisms of corporate governance to facilitate investment in equity capital, thus decreasing the country risk perceived by investors.     

Innovation, workers skills and industrial relations: Empirical evidence from firm-level Italian data

The shifting of labour demand toward relatively more skilled workers has been a hot issue in the economic field for many years. A consolidated explanation for the upskilling phenomenon is that technological–organisational changes have driven the labour demand with detrimental consequences for less skilled workers (skill-biased technological–organisational change). In order to upgrade the skill workforce the firm has at least two main channels at its disposal: the external labour market strategy, mainly based on hiring and firing mechanisms; the internal labour market strategies, which improve the skill base of the employees through training activities.The main objective of the present work is to verify the relations between innovative strategies and both the workforce composition and the training activities, within an integrated framework that also leads us to consider the role of specific aspects of the industrial relations system.The firm level analysis is based on original datasets which include data on manufacturing firms for two Italian local production systems, located in the Emilia-Romagna region.The results suggest that the firms use both the two channels to improve their skill base, which is actually related to the innovation activities, although there is weak supporting evidence of the use of external labour markets to upgrade the workforce skills: the upskilling phenomenon seems to be associated to specific innovative activities in the technological sphere, while specific organisational aspects emerge as detrimental for blue collars. On the side of internal labour market strategies the evidence supports the hypothesis that innovation intensity induces the firms to implement internal procedures in order to upskill the workforce, confirming the importance of internal labour market strategies. Moreover, we have recognized the important role of firm level industrial relations in determining the training activities for the blue collar workers.     

Going global: professional mobility and concerns for LGBT workers

The world of work has regularized the practice of people moving from one country to another to accept job assignments. Travel and relocation are stress-laden endeavours. For LGBT people, the risks can be more complicated than they are for heterosexuals. This article explores particular challenges that LGBT people face when they travel and relocate for business, both domestically and internationally. The article is contextualized with a literature review on sexual minorities and workplace issues, and uses auto-ethnographic stories of three of the authors’ lived experiences as sexual minorities relocating for professional reasons in order to examine issues related to LGBT relocation. These issues include legal, social, cultural and familial considerations. Implications and suggestions for human resource developers are presented, which include acquiring awareness around the psychological and physiological reactions to new and diverse ecologies, or ‘eco-shocks’.     

How emerging digital technologies affect operations management through co-creation. Empirical evidence from the maritime industry

Abstract

Globalization, variation in customer expectations, and the developments connected to Information & Communication Technology are usually considered as the main drivers of changes in Operations Management (OM) strategies by firms in both manufacturing and service industries. Emerging digital technologies, such as Internet of Things or Cloud Computing, represents a novel paradigm that is rapidly affecting on several aspects of everyday-life of private and business users. This paper contributes to extant literature about the relationship between emerging digital technologies and OM, by stressing the value co-creation issue. Specifically, we investigate how emerging digital technologies affect OM through value co-creation in the maritime industry. Our study reports the case of FairWind project, an open technology marine service and graphic user interface enabling sailors to personalize their experience on board through 3rd party boat applications. The case of Fair Wind points out how emerging digital technologies contribute to OM within both organizations and, more in general, maritime industry, as well as the critical role of user’s co-creation in defining and managing on-board operations.     

The 1995 Pension Reform: Equity,Sustainability and Indexation

In financial equilibrium, a pay-as-you-go pension system will offer yields (explicit or implicit) equal to the rate of growth of the incomes subject to the contribution levy or of reasonable proxies such as GDP. One virtue of the contribution-based award formula is that it makes this yield explicit, permitting immediate verification of the system's sustainability. A second virtue is that it ensures equal treatment of all participants. Without prejudicing the constraint of financial sustainability, a pension scheme may choose any one of an infinite number of pairs (combinations) of initial award and indexation rates; or, in other words, any of an infinite set of curves of the total benefit over time. The 1995 pension reform enacted under Lamberto Dini elected zero real indexation, thus permitting higher initial income replacement rates. Insofar as it will generate pension disparities depending on year of retirement, this choice is the likely prelude to creeping real indexation, or recurrent equalizations that will drive the overall yield on contributions above the GDP growth rate and violate the constraint of financial sustainability. Before insoluble problems arise, the reformed system must be amended to decrease income replacement rates to a level compatible with an indexation procedure (be it automatic or discretionary) for adjusting benefits to society's real living standards, as all main pension systems do. The article also criticizes other choices made in the formulation of the law that will prevent the reform from achieving its stated purposes.     

The effect of compliance-improving interventions on the cognitive-behavioural treatment of pathological gambling

This exploratory study investigated the effect of interventions designed to improve compliance and reduce dropout rates during the outpatient treatment of pathological gambling at a University-based gambling treatment clinic. Forty subjects (29 males, 11 females, mean age = 37.6) meeting DSM-IV criteria (APA, 1994) for pathological gambling were randomly assigned to either a cognitive-behavioural treatment or a cognitive-behavioural treatment combined with interventions designed to improve treatment compliance. Compliance was indicated by the completion of all treatment sessions. Outcome measures were DSM-IV criteria assessed by structured clinical interview, South Oaks Gambling Screen scores, and percentage of income gambled. Logistic regression analyses identified pretreatment characteristics predicting compliance and outcome. Compliance-improving interventions significantly reduced dropout rates, resulting in superior outcomes at posttreatment compared to the cognitive behavioural treatment alone. At 9-month follow-up, there was no difference in outcome between treatments, although both produced clinically significant change. Comorbid problem drinking, drug use, and problem gambling duration predicted poor compliance. Poor outcome was predicted by comorbid problem drinking. The clinical implications of these results are discussed in light of the exploratory nature of the study and the need for future research to address compliance, outcome, and comorbidity issues.     

Adolescent Psychological Well‐being,Radicalism, and Activism: The Mediating Role of Social Disconnectedness and the Illegitimacy of the Authorities

The identification of factors that counter youth’s radicalization while promoting democratic activism is a timely social issue. This paper examines the association of psychological well‐being (PWB) with violent radicalism and nonviolent activism, by focusing on the mediating role of both social disconnectedness (SD) and the perceived illegitimacy of the authorities (PIoA). Two mediation structural equation models (full vs. partial) were applied to data collected from 328 Italian adolescents (14–19 years). The results showed how SD and PIoA fully mediated the link of PWB with radicalism (negatively) and activism (positively). This model was further supported when compared with an alternative one proposing PWB as a mediator between SD and PIoA. The findings are discussed in light of the existing literature and provide potential implications for practice.