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Current status data arise in studies where the target measurement is the time of occurrence of some event, but observations
are limited to indicators of whether or not the event has occurred at the time the sample is collected - only the current
status of each individual with respect to event occurrence is observed. Examples of such data arise in several fields, including
demography, epidemiology, econometrics and bioassay. Although estimation of the marginal distribution of times of event occurrence
is well understood, techniques for incorporating covariate information are not well developed. This paper proposes a semiparametric
approach to estimation for regression models of current status data, using techniques from generalized additive modeling and
isotonic regression. This procedure provides simultaneous estimates of the baseline distribution of event times and covariate
effects. No parametric assumptions about the form of the baseline distribution are required. The results are illustrated using
data from a demographic survey of breastfeeding practices in developing countries, and from an epidemiological study of heterosexual
Human Immunodeficiency Virus (HIV) transmission.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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Michael Rosenblum Nicholas P. Jewell Mark van der Laan Stephen Shiboski Ariane van der Straten Nancy Padian 《Journal of the Royal Statistical Society. Series A, (Statistics in Society)》2009,172(2):443-465
Summary. The 'Methods for improving reproductive health in Africa' trial is a recently completed randomized trial that investigated the effect of diaphragm and lubricant gel use in reducing infection by the human immunodeficiency virus (HIV) among susceptible women. 5045 women were randomly assigned to either the active treatment arm or not. Additionally, all subjects in both arms received intensive condom counselling and provision, the 'gold standard' HIV prevention barrier method. There was much lower reported use of condoms in the intervention arm than in the control arm, making it difficult to answer important public health questions based solely on the intention-to-treat analysis. We adapt an analysis technique from causal inference to estimate the 'direct effects' of assignment to the diaphragm arm, adjusting for use of condoms in an appropriate sense. Issues raised in the trial apply to other trials of HIV prevention methods, some of which are currently being conducted or designed. 相似文献
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