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1.
Low dose risk estimation via simultaneous statistical inferences 总被引:2,自引:0,他引:2
Walter W. Piegorsch R. Webster West Wei Pan Ralph L. Kodell 《Journal of the Royal Statistical Society. Series C, Applied statistics》2005,54(1):245-258
Summary. The paper develops and studies simultaneous confidence bounds that are useful for making low dose inferences in quantitative risk analysis. Application is intended for risk assessment studies where human, animal or ecological data are used to set safe low dose levels of a toxic agent, but where study information is limited to high dose levels of the agent. Methods are derived for estimating simultaneous, one-sided, upper confidence limits on risk for end points measured on a continuous scale. From the simultaneous confidence bounds, lower confidence limits on the dose that is associated with a particular risk (often referred to as a bench-mark dose ) are calculated. An important feature of the simultaneous construction is that any inferences that are based on inverting the simultaneous confidence bounds apply automatically to inverse bounds on the bench-mark dose. 相似文献
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We discuss the issue of using benchmark doses for quantifying (excess) risk associated with exposure to environmental hazards. The paradigm of low-dose risk estimation in dose-response modeling is used as the primary application scenario. Emphasis is placed on making simultaneous inferences on benchmark doses when data are in the form of proportions, although the concepts translate easily to other forms of outcome data. 相似文献
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Walter R. Allen 《Sociological Forum》1995,10(4):569-592
Since 1965 hundreds of articles and books have been published about African American families. Nevertheless, our understanding of these families continues to be limited. There is a tendency to gloss over important within-group differences; thus, monolithic, stereotypic and inaccurance portrayals of Black family life are common. This paper sets aside debates of Black family pathology or viability, focusing instead on these families' essential character. The paper seeks to understand Black families on their own terms, locating them in relevant social, historical, political and cultural contexts. Key empirical patterns and trends reveal dramatic changes in Black family geographic location, headship, quality of life and socioeconomic status since 1950.A complex picture is revealed. There has been gradual but steady overall improvement alongside persistent, extreme racial disparties and pronounced class disparities among Black families. The proposed Black Family Socio-Ecological Context model specifies and connects institutional, interpersonal, environmental, temporal and cultural facts that shape the essential character of Black family life in such a way as to produce characteristics simultaneously shared and idiosyncratic. The model also provides an organized, systematic accounting of research and public policy issues relevant to the study of African American families.An early version co-authored with Richard A. English was presented during the National Council on Family Relations Meetings in Portland, Oregon, October 1980. 相似文献
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Spencer G. Niles Walter P. Anderson Gary Goodnough 《The Career development quarterly》1998,46(3):262-275
Responses to the Adult Career Concerns Inventory (ACCI: Super, Thompson, Lindeman, Myers, & Jordaan, 1988) were organized through cluster analysis to identify different ways in which adults use exploratory behavior to cope with career development tasks. Significant differences in life-role salience among the types of adult career explorers identified were also investigated. Findings indicated a variety of ways in which adults use exploratory behavior. However, no significant differences were found in life-role salience among the types of career explorers. The discussion explains how career counselors can interpret their clients' ACCI profiles to select appropriate career interventions. 相似文献
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Quantitative risk assessments for physical, chemical, biological, occupational, or environmental agents rely on scientific studies to support their conclusions. These studies often include relatively few observations, and, as a result, models used to characterize the risk may include large amounts of uncertainty. The motivation, development, and assessment of new methods for risk assessment is facilitated by the availability of a set of experimental studies that span a range of dose‐response patterns that are observed in practice. We describe construction of such a historical database focusing on quantal data in chemical risk assessment, and we employ this database to develop priors in Bayesian analyses. The database is assembled from a variety of existing toxicological data sources and contains 733 separate quantal dose‐response data sets. As an illustration of the database's use, prior distributions for individual model parameters in Bayesian dose‐response analysis are constructed. Results indicate that including prior information based on curated historical data in quantitative risk assessments may help stabilize eventual point estimates, producing dose‐response functions that are more stable and precisely estimated. These in turn produce potency estimates that share the same benefit. We are confident that quantitative risk analysts will find many other applications and issues to explore using this database. 相似文献
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Walter C. Labys 《Journal of Policy Modeling》1980,2(1):121-136
This paper is designed to bring into focus the numerous modeling attempts to analyze commodity price stabilization that have recently appeared. The studies examined begin with the Waugh-Oi-Massell framework and advance to econometric commodity modeling. Such a critique is considered necessary: None of the studies examined has overcome the myriad of problems that analysts have pointed out as essential for assessing the welfare outcomes of price stabilization schemes. As a consequence, stabilization analyses for similar commodities have produced conflicting results regarding predicted welfare outcome. The present appraisal attempts to provide a unity of direction to this work by (1) comparing recieved studies of a theoretical, empirical, and econometric modeling nature, and (2) suggesting possibilities for improving modeling analyses. 相似文献
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Maggie Walter Michele Suina 《International Journal of Social Research Methodology》2019,22(3):233-243
The field of Indigenous methodologies has grown strongly since Tuhiwai Smith’s 1999 groundbreaking book Decolonizing Indigenous Methodologies. For the most part however, there has been a marked absence of quantitative methodologies with the methods aligned with Indigenous methodologies predominantly qualitative. This article proposes that the absence of an Indigenous presence from Indigenous data production has resulted in an overwhelming statistical narrative of deficit for dispossessed Indigenous peoples around the globe. Using the theoretical concept of Indigenous Lifeworlds this article builds on the core premises of Walter and Andersen’s 2013 book Indigenous quantitative methodologies. Arguing for a fundamental disturbance of the Western logics of statistical data the article details recent developments in the field including the emergence of the Indigenous Data Sovereignty movement. The article also explores Indigenous quantitative methodologies in practice using the case study of a Tribal Epidemiology Centre in New Mexico. 相似文献