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排序方式: 共有32条查询结果,搜索用时 31 毫秒
1.
Urban Ecosystems - Biodiversity conservation and restoration in cities is a global challenge for the 21st century. Unlike other common ecosystems, urban landscapes are predominantly covered by...  相似文献   
2.
Statistics and Computing - Variable clustering is important for explanatory analysis. However, only few dedicated methods for variable clustering with the Gaussian graphical model have been...  相似文献   
3.
This study examined the microinteractions of pedestrians in Japan and in the United States as they walked past a confederate. Specifically, the effects of culture, condition (avoid, look-only, and look plus smile) and sex of confederate on glances, smiles, nods, and greetings by passing pedestrians were examined in a field study on over 1000 participants. The hypotheses of (1) lower responsiveness in Japanese pedestrians than in American pedestrians and (2) increased responsiveness as a function of condition were supported in a series of log-linear analyses of pedestrian glances, smiles, nods, and greetings. Both of these main effects were, however, qualified by Culture X Condition interactions on smiles, nods, and greetings, with the large condition effects present in the American pedestrians, but absent in the Japanese pedestrians. The results are discussed in terms of the functions of glances, smiles, nods, and greetings in these brief encounters and how differing cultural norms affect Japanese and American responsiveness. Finally, the limitations of this study and the broader utility of this research paradigm are discussed.
Miles L. PattersonEmail:
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4.
Patient heterogeneity may complicate dose‐finding in phase 1 clinical trials if the dose‐toxicity curves differ between subgroups. Conducting separate trials within subgroups may lead to infeasibly small sample sizes in subgroups having low prevalence. Alternatively,it is not obvious how to conduct a single trial while accounting for heterogeneity. To address this problem,we consider a generalization of the continual reassessment method on the basis of a hierarchical Bayesian dose‐toxicity model that borrows strength between subgroups under the assumption that the subgroups are exchangeable. We evaluate a design using this model that includes subgroup‐specific dose selection and safety rules. A simulation study is presented that includes comparison of this method to 3 alternative approaches,on the basis of nonhierarchical models,that make different types of assumptions about within‐subgroup dose‐toxicity curves. The simulations show that the hierarchical model‐based method is recommended in settings where the dose‐toxicity curves are exchangeable between subgroups. We present practical guidelines for application and provide computer programs for trial simulation and conduct.  相似文献   
5.
Reactions to the O. J. Simpson verdict were analyzed using the Cognitive-Affective Processing System (CAPS) model. Content analyses of participants' open-ended reactions to the verdict revealed that differences in the accessibility of cognitive-affective units and their subsequent activation pathways characterized respondents' reactions, but participants' race appeared to have no direct effect. The results were used to construct cognitive-affective domain maps that underlay elated, dismayed, and ambivalent reactions. By promoting a deeper understanding and appreciation of reactions to the verdict, we believe the domain maps facilitate overcoming the widespread tendency to attribute the cause of divergent reactions to an individual's race. The results have implications for the understanding of cultural differences.  相似文献   
6.
This study explores the heterogeneous effects of minimum wage on innovation of different types of firms. We develop an open‐economy R&D‐based growth model and obtain the following result: raising the minimum wage reduces innovation of firms that use domestic inputs but increases innovation of firms that import foreign inputs. We test this result using city‐level data on minimum wages and firm‐level patent data in China. In accordance with our theory, we find that raising the minimum wage is associated with more innovation by importing firms and less by non‐importing firms. This result survives a battery of robustness checks. (JEL E24, F43, O31)  相似文献   
7.
One of the primary purposes of an oncology dose‐finding trial is to identify an optimal dose (OD) that is both tolerable and has an indication of therapeutic benefit for subjects in subsequent clinical trials. In addition, it is quite important to accelerate early stage trials to shorten the entire period of drug development. However, it is often challenging to make adaptive decisions of dose escalation and de‐escalation in a timely manner because of the fast accrual rate, the difference of outcome evaluation periods for efficacy and toxicity and the late‐onset outcomes. To solve these issues, we propose the time‐to‐event Bayesian optimal interval design to accelerate dose‐finding based on cumulative and pending data of both efficacy and toxicity. The new design, named “TITE‐BOIN‐ET” design, is nonparametric and a model‐assisted design. Thus, it is robust, much simpler, and easier to implement in actual oncology dose‐finding trials compared with the model‐based approaches. These characteristics are quite useful from a practical point of view. A simulation study shows that the TITE‐BOIN‐ET design has advantages compared with the model‐based approaches in both the percentage of correct OD selection and the average number of patients allocated to the ODs across a variety of realistic settings. In addition, the TITE‐BOIN‐ET design significantly shortens the trial duration compared with the designs without sequential enrollment and therefore has the potential to accelerate early stage dose‐finding trials.  相似文献   
8.
Over the past decade, the research on disaster administration has taken a critical look at the command and control operations in disaster response and recovery. Following the notable bureaucratic failures in response to Hurricane Katrina and the tsunami in Indonesia, researchers have focused on disaster administration system. The various actors within the system should focus on sense-making and resilience to be agile in the face of catastrophic events. This study profiles the contributions made through a focus on developing resilience in disaster management. Through a detailed literature review in multiple areas of the disaster management literature, along with illustrative examples from the challenges that agents have faced in several recent global disasters from 2014 to the present, the importance of resilience is highlighted. Areas for future research are included.  相似文献   
9.
The COVID-19 pandemic has severely affected the way of life of communities in Japan. This study examines the pandemic's impact by focusing on a popular activity in Japanese townships: participation in traditional festivals with roots dating back to before the Edo period. These festivals display the social customs of each community and their prosperity from the past to the present. Residents participating in local festivals gain a deep understanding of their personal importance within the community. However, many communities were forced to cancel their festivals in 2020 because of the pandemic. In 2021, many communities attempted to reinstate their traditional festivals, and some of them resumed the festivities with infection control measures in place. This case study examines how people resumed festivals in their communities and the conditions needed for them to reengage with their traditions. Focusing on the Nagahama Hikiyama Festival in Shiga Prefecture, Japan, we demonstrate the resilience of traditional communities in Japan. This study analyzes the reasons for and process of reviving and subsequently implementing traditional festivals and clarifies the positive factors contributing to the resumption of festivals in local communities. It examines the sources of resilience that have been cultivated in these communities and explains how their social capital bridges the gaps between local governments, schools, and broadcasters.  相似文献   
10.
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