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1.
Low dose risk estimation via simultaneous statistical inferences 总被引:2,自引:0,他引:2
Walter W. Piegorsch R. Webster West Wei Pan Ralph L. Kodell 《Journal of the Royal Statistical Society. Series C, Applied statistics》2005,54(1):245-258
Summary. The paper develops and studies simultaneous confidence bounds that are useful for making low dose inferences in quantitative risk analysis. Application is intended for risk assessment studies where human, animal or ecological data are used to set safe low dose levels of a toxic agent, but where study information is limited to high dose levels of the agent. Methods are derived for estimating simultaneous, one-sided, upper confidence limits on risk for end points measured on a continuous scale. From the simultaneous confidence bounds, lower confidence limits on the dose that is associated with a particular risk (often referred to as a bench-mark dose ) are calculated. An important feature of the simultaneous construction is that any inferences that are based on inverting the simultaneous confidence bounds apply automatically to inverse bounds on the bench-mark dose. 相似文献
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We discuss the issue of using benchmark doses for quantifying (excess) risk associated with exposure to environmental hazards. The paradigm of low-dose risk estimation in dose-response modeling is used as the primary application scenario. Emphasis is placed on making simultaneous inferences on benchmark doses when data are in the form of proportions, although the concepts translate easily to other forms of outcome data. 相似文献
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Terence C. Mills 《Journal of applied statistics》2008,35(10):1131-1138
While body fat is the most accurate measure of obesity, its measurement requires special equipment that can be costly and time consuming to operate. Attention has thus typically focused on the easier to calculate body mass index (BMI). However, the ability of BMI to accurately identify obesity has been increasingly questioned. This paper focuses attention on whether more general body mass indices are appropriate measures of body fat. Using a data set of body fat, height, and weight measurements, general models are estimated which nest a wide variety of weight–height indices as special cases. In the absence of a race and gender categorisation, the conventional BMI was found to be the appropriate index with which to predict body fat. When such a categorisation was made, however, the BMI was never selected as the appropriate index. In general, predicted female body fat was some 10 kg higher than that of a male of identical build and predicted % body fat was over 11 percentage points higher, but age effects were smaller for females. Considerable racial differences in predicted body fat were found for males, but such differences were less marked for females. The implications of this finding for interpreting recent research on the effect of obesity on health, society, and economic factors are considered. 相似文献
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Walter R. Allen 《Sociological Forum》1995,10(4):569-592
Since 1965 hundreds of articles and books have been published about African American families. Nevertheless, our understanding of these families continues to be limited. There is a tendency to gloss over important within-group differences; thus, monolithic, stereotypic and inaccurance portrayals of Black family life are common. This paper sets aside debates of Black family pathology or viability, focusing instead on these families' essential character. The paper seeks to understand Black families on their own terms, locating them in relevant social, historical, political and cultural contexts. Key empirical patterns and trends reveal dramatic changes in Black family geographic location, headship, quality of life and socioeconomic status since 1950.A complex picture is revealed. There has been gradual but steady overall improvement alongside persistent, extreme racial disparties and pronounced class disparities among Black families. The proposed Black Family Socio-Ecological Context model specifies and connects institutional, interpersonal, environmental, temporal and cultural facts that shape the essential character of Black family life in such a way as to produce characteristics simultaneously shared and idiosyncratic. The model also provides an organized, systematic accounting of research and public policy issues relevant to the study of African American families.An early version co-authored with Richard A. English was presented during the National Council on Family Relations Meetings in Portland, Oregon, October 1980. 相似文献
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The authors describe a project, begun in 1981, to locate, list, and annotate all the published work based substantially on the census enumerators' books for nineteenth-century censuses for England and Wales. The results are currently available in a computerized file, enabling a variety of searches by topic, geographical area, and type of population. Information is provided on using the data and the computerized bibliography. The authors note that, subsequently, data for censuses of Scotland and Ireland have been added. 相似文献
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Spencer G. Niles Walter P. Anderson Gary Goodnough 《The Career development quarterly》1998,46(3):262-275
Responses to the Adult Career Concerns Inventory (ACCI: Super, Thompson, Lindeman, Myers, & Jordaan, 1988) were organized through cluster analysis to identify different ways in which adults use exploratory behavior to cope with career development tasks. Significant differences in life-role salience among the types of adult career explorers identified were also investigated. Findings indicated a variety of ways in which adults use exploratory behavior. However, no significant differences were found in life-role salience among the types of career explorers. The discussion explains how career counselors can interpret their clients' ACCI profiles to select appropriate career interventions. 相似文献
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Albert J. Mills 《Gender, Work and Organization》1998,5(3):172-188
This article sets out to examine the role of masculinity in the development of a gendered organizational culture over time. The development of images of masculinity within one company — British Airways — is examined through content analysis of company newsletters, advertising copy, annual reports, internal memoranda, and written rules and regulations. Exploring the notion of ‘multiple masculinities’, the article traces the prominent forms of masculinity that emerged in British Airways and assesses their impact on the ways that organizational practices were developed, maintained and understood. Four key corporate images of masculinity are examined — the pilot, the steward, the engineer and the ‘native boy’— and it is argued that those images contributed to the exclusion of women and people of colour from those occupations by laying down cultural rules about the ideal typical characteristics of the job holder. The article concludes by raising questions about the value of a multiple masculinities focus in explaining changing and contradictory practices of discrimination; the primacy of extra-organizational over organizational practices; and the relationship between multiple masculinities and hegemonic masculinity. Further research is suggested into the extent to which hegemonic masculinity is undermined, over time, by changing and contradictory forms of masculinity within definite sites of gender construction. 相似文献