Effects of testosterone replacement therapy on hypogonadal men with osteopenia or osteoporosis: a subanalysis of a prospective randomized controlled study in Japan (EARTH study)

Objective: We investigated the effects of testosterone replacement therapy (TRT) on bone mineral density (BMD) among hypogonadal men with osteopenia/osteoporosis.

Methods: From our previous EARTH study population, 74 patients with a clinical diagnosis of osteopenia or osteoporosis and hypogonadism were included in this study, as the TRT (n?=?35) and control (n?=?34) groups. The TRT group was administered 250?mg of testosterone enanthate injection every 4 weeks for 12 months. The BMD, waist circumference, body mass index, body fat percentage, and muscle volume were measured at baseline and at 12 months. Blood biochemical data, including total cholesterol, triglycerides, HDL-cholesterol, hemoglobin A1c, and adiponectin values were also evaluated.

Results: At the 12-month visit, BMD significantly increased in both groups. However, comparisons on changes of parameter values from baseline to the 12-month visit between the TRT and control groups were significantly different in BMD (5.0?±?5.0 vs. 3.0?±?3.2; p?=?.0434) and in adiponectin value (?0.90?±?3.33 vs. 0.10?±?2.04; p?=?.0192). There were no significant changes in other parameters.

Conclusions: TRT for 12 months could improve BMD with a decrease in adiponectin levels among hypogonadal men with osteopenia/osteoporosis.     

A Probabilistic Approach to Assess External Doses to the Public Considering Spatial Variability of Radioactive Contamination and Interpopulation Differences in Behavior Pattern

Dose assessment is an important issue from the viewpoints of protecting people from radiation exposure and managing postaccident situations adequately. However, the radiation doses received by people cannot be determined with complete accuracy because of the uncertainties and the variability associated with any process of defining individual characteristics and in the dose assessment process itself. In this study, a dose assessment model was developed based on measurements and surveys of individual doses and relevant contributors (i.e., ambient dose rates and behavior patterns) in Fukushima City for four population groups: Fukushima City Office staff, Senior Citizens’ Club, Contractors’ Association, and Agricultural Cooperative. In addition, probabilistic assessments were performed for these population groups by considering the spatial variability of contamination and interpopulation differences resulting from behavior patterns. As a result of comparison with the actual measurements, the assessment results for participants from the Fukushima City Office agreed with the measured values, thereby validating the model and the approach. Although the assessment results obtained for the Senior Citizens’ Club and the Agricultural Cooperative differ partly from the measured values, by addressing further considerations in terms of dose reduction effects due to decontamination and the impact of additional exposure sources in agricultural fields, these results can be improved. By contrast, the measurements obtained for the participants from the Contractors’ Association were not reproduced well in the present study. To assess the doses to this group, further investigations of association members’ work activities and the related dose reduction effects are needed.     

Real and financial shocks,exchange rate regimes and the probability of a currency crisis

We analyze the relationships among shocks, exchange rate regimes, and capital controls in relation to the probability of a currency crisis. Based on the theoretical model by Nakatani (2016, 2017a), we use panel data on 34 developing countries and apply a probit estimation. We find that both productivity shocks and risk premium shocks trigger currency crises, whereas productivity shocks are important for severe currency crises. We also find that the effects of these shocks on the probability of a crisis are larger for floating exchange rate regimes and that capital controls mitigate the effects of productivity shocks in pegged regimes.     

Environmental Sociology in Japan and Environmental Problems in Asian Societies

This paper discusses typical aspects of environmental sociology in Japan and what characteristics can be found in Japanese environmental problems when they are viewed from their relation to environmental problems in Asian societies.
The most prominent feature of environmental sociology in Japan is that it has been mainly the sociology of environmental problems, whereas in the United States is has been mainly the sociology of the environment. The second characteristic is closely related to the first: environmental sociology in Japan has focused on the local community and the life of people and victims affected by environmental problems.
The third property would be that many studies by environmental sociologists have been accumulated by the Japanese Association for Environmental Sociology, which was set up in 1990.
The approach to the study of environmental problems in Asian societies reflects these characteristics. Views from the historical interaction between Japan and other Asian countries are essential to the study of environmental problems in Asian countries.     

Bioaccessibility of Fukushima‐Accident‐Derived Cs in Soils and the Contribution of Soil Ingestion to Radiation Doses in Children

Ingestion of contaminated soil is one potential internal exposure pathway in areas contaminated by the Fukushima Daiichi Nuclear Power Plant accident. Doses from this pathway can be overestimated if the availability of radioactive nuclides in soils for the gastrointestinal tract is not considered. The concept of bioaccessibility has been adopted to evaluate this availability based on in vitro tests. This study evaluated the bioaccessibility of radioactive cesium from soils via the physiologically‐based extraction test (PBET) and the extractability of those via an extraction test with 1 mol/L of hydrochloric acid (HCl). The bioaccessibility obtained in the PBET was 5.3% ± 1%, and the extractability in the tests with HCl was 16% ± 3%. The bioaccessibility was strongly correlated with the extractability. This result indicates the possibility that the extractability in HCl can be used as a good predictor of the bioaccessibility with PBET. In addition, we assessed the doses to children from the ingestion of soil via hand‐to‐mouth activity based on our PBET results using a probabilistic approach considering the spatial distribution of radioactive cesium in Date City in Fukushima Prefecture and the interindividual differences in the surveyed amounts of soil ingestion in Japan. The results of this assessment indicate that even if children were to routinely ingest a large amount of soil with relatively high contamination, the radiation doses from this pathway are negligible compared with doses from external exposure owing to deposited radionuclides in Fukushima Prefecture.     

Shrinkage estimation of location parameters in a multivariate skew-normal distribution

Abstract

This paper studies decision theoretic properties of Stein type shrinkage estimators in simultaneous estimation of location parameters in a multivariate skew-normal distribution with known skewness parameters under a quadratic loss. The benchmark estimator is the best location equivariant estimator which is minimax. A class of shrinkage estimators improving on the best location equivariant estimator is constructed when the dimension of the location parameters is larger than or equal to four. An empirical Bayes estimator is also derived, and motivated from the Bayesian procedure, we suggest a simple skew-adjusted shrinkage estimator and show its dominance property. The performances of these estimators are investigated by simulation.     

A triple test for behavioral economics models and public health policy

We propose a triple test to evaluate the usefulness of behavioral economics models for public health policy. Test 1 is whether the model provides reasonably new insights. Test 2 is on whether these have been properly applied to policy settings. Test 3 is whether they are corroborated by evidence. We exemplify by considering the cases of social interactions models, self-control models and, in relation to health message framing, prospect theory. Out of these sets of models, only a correctly applied prospect theory fully passes the tests at present. Specifically, in broad agreement with the evidence, a gain frame has positive implications for welfare encourages disease prevention activity, though this does not apply if the perceived probability of the bad health outcome is large enough. We see our tests as being useful to identify how much health policy weight policy makers should assign to specific behavioral economic models; they are also useful to verify what next steps would be most useful in further research.     

Stochastic Choice and Revealed Perturbed Utility

Perturbed utility functions—the sum of expected utility and a nonlinear perturbation function—provide a simple and tractable way to model various sorts of stochastic choice. We provide two easily understood conditions each of which characterizes this representation: One condition generalizes the acyclicity condition used in revealed preference theory, and the other generalizes Luce's IIA condition. We relate the discrimination or selectivity of choice rules to properties of their associated perturbations, both across different agents and across decision problems. We also show that these representations correspond to a form of ambiguity‐averse preferences for an agent who is uncertain about her true utility.