The Role of Cancer Risk in the Regulation of Industrial Pollution

The extent of carcinogen regulation under existing U.S. environmental statutes is assessed by developing measures of the scope and stringency of regulation. While concern about cancer risk has played an important political role in obtaining support for pollution control programs, it has not provided the predominant rationale for most regulatory actions taken to date. Less than 20% of all standards established to limit concentrations of chemicals in various media address carcinogens. Restrictions on chemical use are more frequently based on concerns about noncancer human health or ecological effects. Of the chemicals in commercial use which have been identified as potential human carcinogens on the basis of rodent bioassays, only a small proportion are regulated. There is an inverse relationship between the scope of regulatory coverage and the stringency of regulatory requirements: the largest percentages of identified carcinogens are affected by the least stringent requirements, such as information disclosure. Standards based on de minimis cancer risk levels have been established for only 10% of identified carcinogens and are restricted to one medium: water. Complete bans on use have affected very few chemicals. The general role that carcinogenicity now plays in the regulatory process is not dramatically different from that of other adverse human health effects: if a substance is identified as a hazard, it may eventually be subject to economically achievable and technically feasible restrictions.     

Professor mom: Woman's work in a man's world

This essay identifies parallels between the traits assigned to gender work roles and the teaching/research division of labor at research universities. The character and definition of undergraduate teaching at research universities is very similar to what has often been described as women's work.     

Navigating New Socio-Demographic Landscapes: Using Anthropological Demography to Understand the ‘Persistence’ of High and Early Fertility Among British Pakistanis

British Pakistanis continue to have earlier and higher fertility than other ethnic groups in the UK, despite a recent rise in educational and employment opportunities for British Pakistani women. In this paper we present findings from an interview-based study with 91 British Pakistani women and men in the Northeast of England, in order to throw some light on the reproductive choices and constraints that underlie this apparent demographic anomaly. Drawing on detailed reproductive narratives, we show that, contrary to common assumptions within the literature, relatively high and early fertility does not necessarily indicate a passive acceptance of ??cultural norms?? or a reluctance to engage with new social and economic opportunities. For some young women at least, early motherhood represents a deliberate and strategic choice: a way of managing different sets of family-building and other aspirations, embedded within a complex interplay of relationships between individuals, couples and wider families. This study contributes to the emerging ??inter-discipline?? of anthropological demography, which offers important insights into population processes that neither discipline can do alone.     

Temporal Responsiveness in Mother–Child Dialogue: A Longitudinal Analysis of Children with Normal Hearing and Hearing Loss

Dialogue between conversational partners, including mothers and their children, is precisely timed. The predictability of this timing is important for establishing and maintaining interaction, communication, and learning. This longitudinal study examines changes in the response latency of utterances in dialogue between mothers and their normal hearing and hearing‐impaired children between 4 and 60 months of age. Mothers and their children showed parallel developmental trends, responding to each other more quickly at older ages. Beyond these age‐related group effects, significant dyadic effects were found in which individual children's latencies were related to those of their mothers, and vice versa. Developmental patterns did not significantly differ across hearing status groups, which may reflect the role of early identification and intervention in promoting positive developmental outcomes.     

The Media Abuse of Children. Jake's Progress from Demonic Icon to Restored Childhood Innocent

While scholarly analysis of child protection and the media has grown substantially during the 1990s (Aldridge, 1994; Franklin and Parton, 1991; Kitzinger and Skidmore, 1995), studies have ignored a crucial dimension which forms the focus for discussion here. We wish to suggest that media reporting of children and child abuse may itself constitute an abusive activity. Media presentations of children and childhood, since press coverage of the Bulger case in 1993, have assumed a distinctive and sinister guise which, we argue, fundamentally revises the previously held perception of children and childhood. We suggest that this new understanding of childhood is damaging to children and, because of the impact of such media presentations on the public mood and policy climate, harms their interests. The discussion is in three parts. First, newspaper reporting of the Bulger case is analysed to reveal how coverage challenged the idea of childhood as a period of innocence and replaced it with a perception of childhood as essentially ‘evil’. Second, the characterization of Jake, the central figure in Alan Bleasdale's recent television dramaJake's Progress, is analysed to serve as an illustrative exemplar of this new construction of childhood. Finally, we consider the possible messages conveyed by such presentations to perpetrators and victims of abuse.     

Identity work in female‐led creative businesses

This study explores the identity work carried out by three female owner‐managers in creative industry businesses, identified in Government reports as a discriminatory industrial sector for women in the UK. Through the development of narratives by the owners and other participants, observation of practice and review of online and offline materials, three cases emerged. These showed overlapping, different identities developed and performed through identity work. Each presented rational and logical persona as business leaders despite observation showing extensive use of intuition and gut feeling in both creative and entrepreneurial aspects of the business. Intuition and gut feeling were seen as inappropriate at work as they belonged to the home sphere, emotionally based and therefore automatically unreliable. While occupying male stereotypes and avoiding the female realm of emotion at work, these women expressed femininity through their emphasis on the maternal, ‘being a good mother' as a desired ideal being embedded in work as well as home practice.     

A NEW CLASS OF MODELS FOR THE DISCRIMINANT PROBLEM

Discriminant analysis is relevant to business decision making in a variety of contexts, such as when one decides to make or buy a specified component, fund a venture project, or hire a particular person. Potential applications in artificial intelligence, particularly in the area of pattern recognition, have further underscored the importance of the field. A recent innovation in discriminant analysis is provided by special linear programming (LP) models, which offer attractive alternatives to classical statistical approaches. The scope of application in which discriminant analysis can be advantageously employed is broadened by the flexibility to tailor parameters in the LP approaches to reflect diverse goals and by the power to explore the sensitivity of these parameters. In spite of the promise of the LP formulations, however, limitations to their effectiveness have been uncovered in certain settings. A recent advance involving a normalization construct removes some of the limitations but entails solving the LP model twice (to allow for different signs of a normalization constant) and does not yield equivalent solutions for different rotations of the problem data. This paper introduces a new model and a new class of normalizations that remedy both remaining limitations, making it possible to take advantage of the modeling capabilities of the LP formulations without the attendant shortcomings encountered by earlier investigations. Our development shows by empirical testing and illustrative analysis that the quality of solutions from LP discriminant approaches is more favorable (relative to the classical model) than previously supposed.     

Functional analysis of high-content high-throughput imaging data

High-content automated imaging platforms allow the multiplexing of several targets simultaneously to generate multi-parametric single-cell data sets over extended periods of time. Typically, standard simple measures such as mean value of all cells at every time point are calculated to summarize the temporal process, resulting in loss of time dynamics of the single cells. Multiple experiments are performed but observation time points are not necessarily identical, leading to difficulties when integrating summary measures from different experiments. We used functional data analysis to analyze continuous curve data, where the temporal process of a response variable for each single cell can be described using a smooth curve. This allows analyses to be performed on continuous functions, rather than on original discrete data points. Functional regression models were applied to determine common temporal characteristics of a set of single cell curves and random effects were employed in the models to explain variation between experiments. The aim of the multiplexing approach is to simultaneously analyze the effect of a large number of compounds in comparison to control to discriminate between their mode of action. Functional principal component analysis based on T-statistic curves for pairwise comparison to control was used to study time-dependent compound effects.