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Federal and other regulatory agencies often use or claim to use a weight of evidence (WoE) approach in chemical evaluation. Their approaches to the use of WoE, however, differ significantly, rely heavily on subjective professional judgment, and merit improvement. We review uses of WoE approaches in key articles in the peer‐reviewed scientific literature, and find significant variations. We find that a hypothesis‐based WoE approach, developed by Lorenz Rhomberg et al., can provide a stronger scientific basis for chemical assessment while improving transparency and preserving the appropriate scope of professional judgment. Their approach, while still evolving, relies on the explicit specification of the hypothesized basis for using the information at hand to infer the ability of an agent to cause human health impacts or, more broadly, affect other endpoints of concern. We describe and endorse such a hypothesis‐based WoE approach to chemical evaluation.  相似文献   
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Gray divorces, or divorces at and over the age of 50, are increasing in the United States. This article explores this population's interest in remarrying after a divorce by sex within the context of a prospective, role exit theoretical framework. In‐depth, qualitative interviews with 40 women and 39 men who have experienced a gray divorce were analyzed using grounded theory methodology. There were significant gender differences with respect to receptivity to remarriage among those who had undergone a gray divorce. More specifically, the most common theme expressed by women involved firmly rejecting remarriage as a part of their futures. The remaining themes articulated by women were conditional pro‐remarriage views and then even less commonly, unconditional pro‐remarriage views. In contrast, the most common theme among men was that they remained very open to remarriage, either unconditionally or under specified conditions; only a small number rejected the prospect entirely. These findings highlight the differences in the remarriage decision from both the female and male perspectives for this population.  相似文献   
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Framed by Relational Dialectics Theory, this study explores the ways adult, former foster children discursively construct meanings of “family.” Contrapuntal analysis of 24 interviews revealed two discourses as competing to constitute family: the Discourse of Family as Irreplaceable and Inescapable (Permanence) and the Discourse of Family as Performative Kinning (Performance). Permanence was constituted by themes of biology and historical connection, reifying normative understandings. Performance, comprised of role enactment, need for tolerance, and unconditional love, challenged the Permanence discourse. Throughout the narratives, Performance competed with Permanence for dominance, illustrating the cultural pervasiveness and power of Permanence yet, in some moments, privileging the marginalized Performance discourse. This discursive competition constructed meanings of family in narratives of life before, during, and after foster care. Overall, participant’s talk constructed complex webs of family relationships, allowing access to an important social institution—family—regardless of the presence/absence of culturally valued markers of family (e.g., biology, legality).  相似文献   
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The paper explores the degree to which Indigenous groups perceive that resource management plans they develop are able to help deliver outcomes they seek through formal planning systems. It does this by a case study of practice in Aotearoa New Zealand. Some Indigenous groups are concerned they are being encouraged to devote considerable effort to production of major planning documents for use in interaction with environmental agencies, yet in practice, such plans can appear to have a limited role in bringing about desired change or affecting wider planning processes. The research contributes a New Zealand dimension to this international debate.  相似文献   
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The scientific community has pronounced climate change unequivocal and its consequences disastrous. Yet Americans' behavioral response to the global social problem of environmental degradation has been largely confined to the individual act of recycling. This article examines why Americans are not doing more to address climate change and other environmental issues. Taking a cognitive sociological perspective, I describe how Americans think about environmental issues and pro‐environmental behavior. I draw on Swidler's concept of a “cultural tool kit,” to examine the cultural narratives Americans use to account for the small amount of pro‐environmental behavior they perform. The act of recycling functions as a synecdoche for pro‐environmental behavior in general, allowing individuals to over‐claim the significance of a modest amount of pro‐environmental behavior. I argue that Americans' failure to engage with environmental issues at a collective level is rooted in the individualized culture of American environmentalism.  相似文献   
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The fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) is scheduled for publication in 2013. It will include several changes to the diagnosis of pathological gambling: the name of the disorder will be altered, the threshold for diagnosis will decrease, and one criterion will be removed. This paper reviews the rationale for these changes and addresses how they may impact diagnosis and treatment of the disorder, as well as potential for future research in the field.  相似文献   
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This article engages a discussion of Raymond Williams claim that culture is ordinary to explore some of the ways in which racializing culture is embedded in everyday interactions and processes of identification that found subjectivity. It argues that there is a pressing need for social policy analysts to come to grips with the mechanisms through which ‘culture’ comes to be racialized and an object/subject of governance and suggests that current, high-profile articulations of the ‘problems’ of multiculturalism, profoundly hinder such a development.  相似文献   
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Biologically Motivated Cancer Risk Models   总被引:3,自引:0,他引:3  
A two-stage dose response model is proposed for use in cancer risk assessment. The model assumes that transformation probabilities and cellular dynamics are exposure- and time-dependent.  相似文献   
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