A new long-term survival model with dispersion induced by discrete frailty

Lifetime Data Analysis - Frailty models are generally used to model heterogeneity between the individuals. The distribution of the frailty variable is often assumed to be continuous. However, there...     

Inference and Decision Making for 21st-Century Drug Development and Approval

ABSTRACT

The cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making.     

“Who generates this city”? Socialist strategy in contemporary London

This essay, based on a “militant ethnography” of the attempts of the small radical grassroots activist group, Our London (a pseudonym), to mobilize a collective oppositional politics through activities around an election campaign, engages critically with E. Laclau and C. Mouffe's arguments on discourse and collectivity in Hegemony and Socialist Strategy (London: Verso, 1985). I argue, on the basis of my findings, that while their model does provide insights that help describe the process of building collectivity from among disparate perspectives and identities, we need to go beyond a focus on discourse alone and consider the ways politics is shaped by material contexts. This is necessary if we are to understand the continued appeal of class politics as well as the difficulties in mobilizing collectivity in highly unequal and fragmented cities. From an activist perspective, the essay also highlights how developing a conception of collective interests and a critique of overarching systems of exploitation can be important in building political unity.     

Frustration in Infancy: Implications for Emotion Regulation,Physiological Processes,and Temperament

A study sample of 162 six‐month‐old children was selected from a larger sample of 346 infants on the basis of parents' report of their infants' temperament and a laboratory assessment of temperament. Infants were classified as easily frustrated and less easily frustrated and compared on a number of emotion regulation, physiology, and temperament measures. Results indicated that male and female infants were equally likely to be classified as frustrated and less easily frustrated; however, male infants were less able to regulate physiologically. Easily frustrated infants used different emotion regulation strategies and were observed to be less attentive and more active than less easily frustrated infants when observed in the laboratory. These infants were also characterized by their parents as more active, less attentive, and more distressed to novelty. Infants classified as easily frustrated were more reactive physiologically and less able to regulate physiological reactivity than their less easily frustrated counterparts. It is hypothesized that this cluster of characteristics may constitute a unique temperamental type that may have implications for other types of behavioral functioning. Limitations of the study are that observations are based on a single brief assessment of the infant, modest effect sizes were found, and the study is cross‐sectional.     

Editorial

Ohne Zusammenfassung

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Editorial

     

The Young and the Realigning: A Test of the Socialization Theory of Realignment

Recent research has demonstrated that Democrats and Republicansare divided along religious lines–98) confirm that thelink between religiosity and Republican Party identificationis stronger among younger than older voters.     

Volume 30

Theory and Society -     

Book Review: A Generation Divided: The New Left,The New Right,and the 1960s. By Rebecca E. Klatch. Berkeley: University of California Press, 1999. 386 pages,paperback, ISBN: 0-520-21714-4

Qualitative Sociology -