Multiple event times in the presence of informative censoring: modeling and analysis by copulas

Motivated by a breast cancer research program, this paper is concerned with the joint survivor function of multiple event times when their observations are subject to informative censoring caused by a terminating event. We formulate the correlation of the multiple event times together with the time to the terminating event by an Archimedean copula to account for the informative censoring. Adapting the widely used two-stage procedure under a copula model, we propose an easy-to-implement pseudo-likelihood based procedure for estimating the model parameters. The approach yields a new estimator for the marginal distribution of a single event time with semicompeting-risks data. We conduct both asymptotics and simulation studies to examine the proposed approach in consistency, efficiency, and robustness. Data from the breast cancer program are employed to illustrate this research.

     

External knowledge search,absorptive capacity and radical innovation in high-technology firms

Open innovation and absorptive capacity are two concepts based on the idea that companies can leverage the knowledge generated externally to improve their innovation performance. The aim of this paper is to analyse the joint effect of open innovation and absorptive capacity on a firm's radical innovation. Open innovation is expressed in terms of external search breadth and depth strategies and absorptive capacity is described by distinguishing between potential and realized absorptive capacity. In order to test our hypotheses, we carried out empirical research in firms operating in high-technology industries. The results indicate that internal routines and processes for absorbing external knowledge help explain radical innovation as they show a significant effect of potential and realized absorptive capacity. Also, there is a moderating effect of absorptive capacity on open innovation. Specifically, potential absorptive capacity exerts a positive effect on the relationship between external search breadth and depth and radical innovation. Realized absorptive capacity moderates the influence of external search breadth. These findings confirm the complementary nature of absorptive capacity and open innovation search strategies on radical innovation.     

对建构主义教学观的几点认识

围绕建构主义教学观与传统教学观、建构主义教学策略、建构主义教学模式等几个方面 ,就数学教学谈了对建构主义教学观的几点认识     

基于TMS320C40的FFT算法改进及应用

讨论了充分利用C4 0的硬件并行结构进行实数FFT的并行算法 ,并在地震勘探信号处理中得以应用     

蛋白组学方法应用于人肺癌组织蛋白表达的研究

采用蛋白组学方法,利用4例中国肺癌患者的切除肺癌组织测定了磷癌(SQCLC)的蛋白表达 从双向电泳(2-DEgel)切下53个点,49个蛋白与数据库搜索结果吻合。在鉴定的24个蛋白中,17个蛋白有报道是与肺癌相关的蛋白其7个蛋白与人类其它癌症相关。所建立的蛋白组学方法能够用于建立一种基于组织的化验方法,发现肺癌患者组织中表达的蛋白标记物以用于癌症的分子学诊断。     

福州市实行土地"阳光交易"的实践与思考

城市土地是最宝贵的城市资源,也是城市政府拥有的和可支配的一份最大的国有资产.为认真管理好,精心经营好城市土地,福州市积极顺应社会主义市场经济的发展,主动适应我国加入WTO的新形势,在全省率先倡导并实行经营性国有土地使用权公开招标拍卖,大大增强了政府权力运行的透明度,从源头上遏制了腐败现象的滋生;同时也为全社会提供了一个公开、公正、公平竞争的平台,得到了各界和广大开发商的高度评价,并将土地公开招标拍卖称之为"阳光下的交易".     

论苗族刺绣及其传承

苗族刺绣已被列入首批国家级非物质文化遗产，具有鲜明的艺术特色，但由于受传承方式等的影响，苗绣有濒临失传危机。因此，必须采取多种措施，强化苗绣的保护传承和开发利用。     

滑坡的成因及其危害分析

给出了滑坡的定义和滑坡的分类,研究了滑坡的形成条件,讨论了滑坡所造成的危害,为滑坡治理打下必要的理论基础。     

局部Haar条件下的变形非线性L逼近

本文讨论了局部Ｈａａｒ条件下变形的非线性Ｌ逼近，得到了包括交错定理在内的特征定理、唯一性和强唯一性定理。