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Statistics and Computing - As a workaround for the lack of transitive transformations on linear network structures, which are required to consider different notions of distributional invariance,... 相似文献
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Jorge Morales Pedraza 《Public Organization Review》2014,14(1):19-33
The reduction or the complete elimination of specific types of weapons, particularly the elimination of all weapons of mass destruction, is one of the most important challenges that the international community should face in the 21th century. In this paper, a group of proposals on the possible roles to be played by the International Atomic Energy Agency (IAEA), the Organisation for the Prohibition of Chemical Weapons (OPCW), the Comprehensive Nuclear-Test-Ban Treaty Organisation (CTBTO) and the Conference on Disarmament (CD) is included. 相似文献
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In this paper, we study space–time generalized additive models. We apply the penalyzed likelihood method to fit generalized additive models (GAMs) for nonseparable spatio-temporal correlated data in order to improve the estimation of the response and smooth terms of GAMs. The results show that our space–time generalized additive models estimated response and smooth terms reasonable well, and in addition, the mean squared error, mean absolute deviation and coverage intervals improved considerably compared to the classic GAM. An application on particulate matter concentration in the North-Italian region of Piemonte is also presented. 相似文献
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In this study, the components of extra-Poisson variability are estimated assuming random effect models under a Bayesian approach. A standard existing methodology to estimate extra-Poisson variability assumes a negative binomial distribution. The obtained results show that using the proposed random effect model it is possible to get more accurate estimates for the extra-Poisson variability components when compared to the use of a negative binomial distribution where it is possible to estimate only one component of extra-Poisson variability. Some illustrative examples are introduced considering real data sets. 相似文献
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Jorge Quiroz Richard Montes Heliang Shi Satrajit Roychoudhury 《Pharmaceutical statistics》2019,18(3):316-328
Assessment of analytical similarity of tier 1 quality attributes is based on a set of hypotheses that tests the mean difference of reference and test products against a margin adjusted for standard deviation of the reference product. Thus, proper assessment of the biosimilarity hypothesis requires statistical tests that account for the uncertainty associated with the estimations of the mean differences and the standard deviation of the reference product. Recently, a linear reformulation of the biosimilarity hypothesis has been proposed, which facilitates development and implementation of statistical tests. These statistical tests account for the uncertainty in the estimation process of all the unknown parameters. In this paper, we survey methods for constructing confidence intervals for testing the linearized reformulation of the biosimilarity hypothesis and also compare the performance of the methods. We discuss test procedures using confidence intervals to make possible comparison among recently developed methods as well as other previously developed methods that have not been applied for demonstrating analytical similarity. A computer simulation study was conducted to compare the performance of the methods based on the ability to maintain the test size and power, as well as computational complexity. We demonstrate the methods using two example applications. At the end, we make recommendations concerning the use of the methods. 相似文献
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Dobbs Cynnamon Escobedo Francisco J. Clerici Nicola de la Barrera Francisco Eleuterio Ana Alice MacGregor-Fors Ian Reyes-Paecke Sonia Vásquez Alexis Zea Camaño Jorge Danilo Hernández H. Jaime 《Urban Ecosystems》2019,22(1):173-187
Urban Ecosystems - Latin America and the Caribbean (LAC) is one of the most urbanized and biologically diverse regions in the world but is often characterized by weak environmental governance and... 相似文献
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Sociological inquiry into the natural sciences has shown that they are contingent, social constructions. However, Science Studies research has been obstructed by epistemological conflicts about the nature of science and theoretical perspectives upon studying it. Bourdieu's sociology of science is under‐utilized in this field, as he addresses these obstructions and offers a way forward. Bourdieu argues that researchers have failed to distinguish between sociological and philosophical approaches in social science, thus committing the ‘scholastic fallacy’. In conjunction with this fallacy, the logic of the Science Studies field produces a tendency towards disciplinary confusion, philosophical radicalization, and crisis. These patterns were expressed in the ‘science wars’. The field has followed a philosophical path rather than a sociological one, and its progress has been obstructed. While some of Bourdieu's philosophical arguments remain problematic, his reflexive sociology allows us to differentiate philosophical from sociological approaches, providing an alternative direction for Science Studies. 相似文献