Age Is But a Number? An Exploration of Age Differences in Episodic Volunteering

VOLUNTAS: International Journal of Voluntary and Nonprofit Organizations - Age has long been understood as a strong demographic determinant of volunteering. However, to date, limited literature...     

雷锋生命价值的三重维度及当代意蕴

雷锋的生命价值从历史、空间、境界三重维度上表现为延伸性、普遍性和超越性。雷锋的生命价值符合人与社会全面发展进步的需要,即符合人的超越性的要求、符合群体共同发展的要求、符合中华民族道德实践的要求、符合中国共产党的宗旨要求,是对生命为什么有价值、生命价值是什么、怎样实现生命价值问题的直接解答。     

A new long-term survival model with dispersion induced by discrete frailty

Lifetime Data Analysis - Frailty models are generally used to model heterogeneity between the individuals. The distribution of the frailty variable is often assumed to be continuous. However, there...     

Interval estimation for conformance proportions of multiple quality characteristics

A conformance proportion is an important and useful index to assess industrial quality improvement. Statistical confidence limits for a conformance proportion are usually required not only to perform statistical significance tests, but also to provide useful information for determining practical significance. In this article, we propose approaches for constructing statistical confidence limits for a conformance proportion of multiple quality characteristics. Under the assumption that the variables of interest are distributed with a multivariate normal distribution, we develop an approach based on the concept of a fiducial generalized pivotal quantity (FGPQ). Without any distribution assumption on the variables, we apply some confidence interval construction methods for the conformance proportion by treating it as the probability of a success in a binomial distribution. The performance of the proposed methods is evaluated through detailed simulation studies. The results reveal that the simulated coverage probability (cp) for the FGPQ-based method is generally larger than the claimed value. On the other hand, one of the binomial distribution-based methods, that is, the standard method suggested in classical textbooks, appears to have smaller simulated cps than the nominal level. Two alternatives to the standard method are found to maintain their simulated cps sufficiently close to the claimed level, and hence their performances are judged to be satisfactory. In addition, three examples are given to illustrate the application of the proposed methods.     

领导干部党性修养评价机制研究

建立健全领导干部党性修养评价机制,是加强党的执政能力建设,建设高素质执政骨干队伍的客观需要。坚定的政治信念、牢固的党纪意识、严谨的自律能力、优秀的道德品质和勤勉的工作作风是评价领导干部党性修养的主要内容。要明确评价领导干部党性修养的指导思想、评价主体和评价原则,要建立健全领导干部党性修养的评价指标体系,不断探索科学的评价领导干部党性修养的方式方法。     

Inference and Decision Making for 21st-Century Drug Development and Approval

ABSTRACT

The cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making.     

都市独生子女特性分析

计划生育政策下的当今都市环境中生存的独生子女群体,其特性大异于前代人,压力源亦异于前人,所思所念以及心理困扰极具特点,进入青春期后特征尤为明显。抓住当今都市独生子女的本质特征,对未来青少年教育的方向及方式具有特殊意义和价值。