Transnational Grannies: The Changing Family Responsibilities of Elderly African Caribbean-Born Women Resident in Britain

This paper explores the role and position of grandmothers in African-Caribbean families resident in Britain. The data used for this paper comes fromm a sample of 180 life-history interviews collected in 1995–1996 from three generations of Caribbean-origin people living in Britain and the Caribbean. Findings from this research suggest that African-Caribbean grandmothers resident in Britain have come to play a less active role within their immediate family compared to earlier historical periods. At the same time however, these grandmothers have come to take on a more a transnational emissary role for their family and kin located throughout North America and Europe. Caribbean-born grandmothers appear to be using more modern means for fulfilling certain traditional tasks like child shifting, story telling or acting as a social safety net. Using their agency African Caribbean-born grandmothers have been able to carve out new niches for themselves despite changes in family structure brought about by migration and settlement patterns in Britain.     

Stability analysis using mixed models: A critique of tolerance interval methods and a probabilistic solution

Recently, tolerance interval approaches to the calculation of a shelf life of a drug product have been proposed in the literature. These address the belief that shelf life should be related to control of a certain proportion of batches being out of specification. We question the appropriateness of the tolerance interval approach. Our concerns relate to the computational challenges and practical interpretations of the method. We provide an alternative Bayesian approach, which directly controls the desired proportion of batches falling out of specification assuming a controlled manufacturing process. The approach has an intuitive interpretation and posterior distributions are straightforward to compute. If prior information on the fixed and random parameters is available, a Bayesian approach can provide additional benefits both to the company and the consumer. It also avoids many of the computational challenges with the tolerance interval methodology.     

The current state of Bayesian methods in nonclinical pharmaceutical statistics: Survey results and recommendations from the DIA/ASA-BIOP Nonclinical Bayesian Working Group

The use of Bayesian methods to support pharmaceutical product development has grown in recent years. In clinical statistics, the drive to provide faster access for patients to medical treatments has led to a heightened focus by industry and regulatory authorities on innovative clinical trial designs, including those that apply Bayesian methods. In nonclinical statistics, Bayesian applications have also made advances. However, they have been embraced far more slowly in the nonclinical area than in the clinical counterpart. In this article, we explore some of the reasons for this slower rate of adoption. We also present the results of a survey conducted for the purpose of understanding the current state of Bayesian application in nonclinical areas and for identifying areas of priority for the DIA/ASA-BIOP Nonclinical Bayesian Working Group. The survey explored current usage, hurdles, perceptions, and training needs for Bayesian methods among nonclinical statisticians. Based on the survey results, a set of recommendations is provided to help guide the future advancement of Bayesian applications in nonclinical pharmaceutical statistics.     

Three current issues in ethnic and racial studies

Prevailing orthodoxies in British studies of ethnic and racial relations have been challenged, most recently by perspectives developed within cultural studies. The issues that divide the contending parties have still to be clarified. Three of them appear to be: (i) problem definition; (ii) problem selection; and (iii) conceptual obsolescence.     

Contents of Volume 51

Volume Contents

Contents of Volume 51