Gentrifikation in zwei Wohngebieten von KölnGentrification in two residential areas of Cologne

We examine the process of Gentrification in two residential areas of Cologne, Germany: Deutz and Mülheim. The theory underlying the study is a phase (or stage) model of Gentrification in which indicators and their values are attributed to each phase. The hypotheses derived from the model pertain to changes in the social structure, rents and the spatial distribution of social groups such as “pioneers”, “gentrifiers” and “others”. We further assume both areas to be in different phases of Gentrification.     

Bargaining over waiting time in ultimatum game experiments

While preference-based explanations play an increasing role in economics and sociology, the accurate measurement of social preferences deserves more attention. Most laboratory experiments measure social preferences by studying the division of “a cake that nobody had to bake” (Güth and Kliemt, 2003). This article reports results of the first ultimatum game experiment with bargaining over waiting time. The experiment was created to avoid effects of windfall gains. In contrast to donated money, time is not endowed by the experimenter and implies a natural loss to subjects. This allows for a better measurement of the inherent conflict in the ultimatum game. We implemented three anonymity conditions; one baseline condition, one condition with anonymity among subjects and one double-blind condition in which the experimenter did not know the division of waiting time. While we expected to observe less other-regarding behavior in ultimatum game bargaining over time, our experimental results rather confirm previous ultimatum game experiments, in which people bargained over money. The modal offer was half of the waiting time and only one offer was rejected. Interestingly, anonymity did not change the results significantly. In conclusion, our experiment confirms other-regarding behavior in the ultimatum game.     

Sample size planning for phase II trials based on success probabilities for phase III

In recent years, high failure rates in phase III trials were observed. One of the main reasons is overoptimistic assumptions for the planning of phase III resulting from limited phase II information and/or unawareness of realistic success probabilities. We present an approach for planning a phase II trial in a time‐to‐event setting that considers the whole phase II/III clinical development programme. We derive stopping boundaries after phase II that minimise the number of events under side conditions for the conditional probabilities of correct go/no‐go decision after phase II as well as the conditional success probabilities for phase III. In addition, we give general recommendations for the choice of phase II sample size. Our simulations show that unconditional probabilities of go/no‐go decision as well as the unconditional success probabilities for phase III are influenced by the number of events observed in phase II. However, choosing more than 150 events in phase II seems not necessary as the impact on these probabilities then becomes quite small. We recommend considering aspects like the number of compounds in phase II and the resources available when determining the sample size. The lower the number of compounds and the lower the resources are for phase III, the higher the investment for phase II should be. Copyright © 2015 John Wiley & Sons, Ltd.     

The development of amyloid beta protein deposits in the aged brain

The deposition of amyloid beta protein (Abeta) in the human brain and the generation of neurofibrillary tangles are the histopathological hallmarks of Alzheimer's disease. Accumulation of Abeta takes place in senile plaques and in cerebrovascular deposits as a result of an imbalance between Abeta production and clearance. This Review describes the different types of Abeta deposits, which can be distinguished by their morphology and by the hierarchical involvement of distinct areas of the brain in Abeta deposition. The role of intracellular Abeta in Abeta deposition and the mechanism of Abeta toxicity are also discussed.     

Progression-free survival in oncological clinical studies: Assessment time bias and methods for its correction

Progression-free survival (PFS) is a frequently used endpoint in oncological clinical studies. In case of PFS, potential events are progression and death. Progressions are usually observed delayed as they can be diagnosed not before the next study visit. For this reason potential bias of treatment effect estimates for progression-free survival is a concern. In randomized trials and for relative treatment effects measures like hazard ratios, bias-correcting methods are not necessarily required or have been proposed before. However, less is known on cross-trial comparisons of absolute outcome measures like median survival times. This paper proposes a new method for correcting the assessment time bias of progression-free survival estimates to allow a fair cross-trial comparison of median PFS. Using median PFS for example, the presented method approximates the unknown posterior distribution by a Bayesian approach based on simulations. It is shown that the proposed method leads to a substantial reduction of bias as compared to estimates derived from maximum likelihood or Kaplan–Meier estimates. Bias could be reduced by more than 90% over a broad range of considered situations differing in assessment times and underlying distributions. By coverage probabilities of at least 94% based on the credibility interval of the posterior distribution the resulting parameters hold common confidence levels. In summary, the proposed approach is shown to be useful for a cross-trial comparison of median PFS.     

Optimal paired comparison designs for first-order interactions

In many fields of applications paired comparisons are used in which either full or partial profiles of the alternatives are presented. For this situation we introduce an appropriate model and derive optimal designs in the presence of interactions when all attributes have the same number of levels.     

Logistic regression analyses for indirect data

The article’s topic is logistic regression for direct data on the covariates, but indirect data on the endogenous variable. The indirect data may result from a privacy-protecting survey procedure for sensitive characteristics or from statistical disclosure control. Various procedures to generate the indirect data exist. However, we show that it is possible to develop a general approach for logistic regression analyses with indirect data that covers many procedures. We first derive a general algorithm for the maximum likelihood estimation and a general procedure for variance estimation. Subsequently, lots of examples demonstrate the broad applicability of our general framework.     

Personelle Unternehmensverflechtung und Vorstandsgehälter

Personal linkages between the biggest German corporations is subject to a special survey by the Monopolies Commission every two years. We use linkage data ranging from 2000–2006 to examine the impact of personal linkage on the compensation of management board members. The empirical analysis reveals a positive relation between compensation of management board members and the amount of corporation-linkages by additional supervisory board mandates of members of the management board. At the same time, the performance of the sending firms has no influence on the likelihood to receive further supervisory board seats.