Assessing convergence diagnostic tests for Bayesian Cox regression

The Markov chain Monte Carlo (MCMC) method generates samples from the posterior distribution and uses these samples to approximate expectations of quantities of interest. For the process, researchers have to decide whether the Markov chain has reached the desired posterior distribution. Using convergence diagnostic tests are very important to decide whether the Markov chain has reached the target distribution. Our interest in this study was to compare the performances of convergence diagnostic tests for all parameters of Bayesian Cox regression model with different number of iterations by using a simulation and a real lung cancer dataset.     

A useful approach to identify the multicollinearity in the presence of outliers

The presence of outliers in the data sets affects the structure of multicollinearity which arises from a high degree of correlation between explanatory variables in a linear regression analysis. This affect could be seen as an increase or decrease in the diagnostics used to determine multicollinearity. Thus, the cases of outliers reduce the reliability of diagnostics such as variance inflation factors, condition numbers and variance decomposition proportions. In this study, we propose to use a robust estimation of the correlation matrix obtained by the minimum covariance determinant method to determine the diagnostics of multicollinearity in the presence of outliers. As a result, the present paper demonstrates that the diagnostics of multicollinearity obtained by the robust estimation of the correlation matrix are more reliable in the presence of outliers.     

Factors causing occurrence of artificial dif: A simulation study for dichotomous data

ABSTRACT

In modern test theory, differential item functioning (DIF) appears where respondents from two different groups have the same ability but different probability to respond to an item correctly. If some items favouring one group lead to the appearance of DIF in any other item favouring the other group, this type of problem is called artificial differential item functioning (A-DIF). The purpose of this paper is to deal with the effect of different factors causing A-DIF under the Rasch theoretical model for dichotomous responses. A simulation study was conducted to explore how various factors affect real DIF and simultaneous A-DIF expected proportion including total sample size, percentage of individuals in focal and reference groups, percentage of items exhibiting real DIF and DIF magnitude for two item sets including 10 and 20 items. It is concluded that DIF magnitude is the most essential factor while evaluating A-DIF for each item set. This is followed by percent of items exhibiting real-DIF.     

Health professionals' attitude toward euthanasia: a cross-sectional study from Turkey

There is an ongoing debate on the definition of euthanasia and attempts to change laws about euthanasia and its practice in many countries. It is the medical doctors and the other health professionals who will elucidate the issue. Therefore, we performed this study to reveal attitude of Turkish health professionals toward euthanasia. This is an observational and cross-sectional study and data were collected with a questionnaire. The questionnaire was distributed to 545 health professionals in Samsun, a city in the Black Sea Region in Turkey. Data were analyzed with SPSS package programs. Of all health professionals included in the study, 43.5% were medical doctors and 45.5% auxiliary health professionals. Of all participants, 33.6% did not object to euthanasia and 7.9% were asked to perform euthanasia. Eighty point seven percent of the participants noted that euthanasia could be abused even if a euthanasia law were passed. It can be concluded that the health professionals should have a chance to discuss euthanasia and that their attitude toward and their expectations and worries about euthanasia should be taken into account when a euthanasia law is drafted.     

A comparison of different procedures for principal component analysis in the presence of outliers

Principal component analysis (PCA) is a popular technique that is useful for dimensionality reduction but it is affected by the presence of outliers. The outlier sensitivity of classical PCA (CPCA) has caused the development of new approaches. Effects of using estimates obtained by expectation–maximization – EM and multiple imputation – MI instead of outliers were examined on the artificial and a real data set. Furthermore, robust PCA based on minimum covariance determinant (MCD), PCA based on estimates obtained by EM instead of outliers and PCA based on estimates obtained by MI instead of outliers were compared with the results of CPCA. In this study, we tried to show the effects of using estimates obtained by MI and EM instead of outliers, depending on the ratio of outliers in data set. Finally, when the ratio of outliers exceeds 20%, we suggest the use of estimates obtained by MI and EM instead of outliers as an alternative approach.     

On the BLUEs in Two Linear Models via C. R. Rao's Pandora's Box

We consider the estimation of the parameters in two partitioned linear models, denoted by 𝒜 = {y, X ₁ β ₁ + X ₂ β ₂, V _𝒜} and ? = {y, X ₁ β ₁ + X ₂ β ₂, V _?}, which we call full models. Correspondingly, we define submodels 𝒜₁ = {y, X ₁ β ₁, V _𝒜} and ?₁ = {y, X ₁ β ₁, V _?}. Using the so-called Pandora's Box approach introduced by Rao (1971 Rao , C. R. ( 1971 ). Unified theory of linear estimation . Sankhy?, Ser. A 33 : 371 – 394 . [Corrigendum (1972), 34, p. 194, 477.]  [Google Scholar], we give new necessary and sufficient conditions for the equality between the best linear unbiased estimators (BLUEs) of X ₁ β ₁ under 𝒜₁ and ?₁ as well as under 𝒜 and ?. In our considerations we will utilise the Frisch–Waugh–Lovell theorem which provides a connection between the full model 𝒜 and the reduced model 𝒜 _r  = {M ₂ y, M ₂ X ₁ β ₁, M ₂ V _𝒜 M ₂} with M ₂ being an appropriate orthogonal projector. Moreover, we consider the equality of the BLUEs under the full models assuming that they are equal under the submodels.     

Using informative priors for handling missing data problem in Cox regression

The aim of this study is to determine the effect of informative priors for variables with missing value and to compare Bayesian Cox regression and Cox regression analysis. For this purpose, firstly simulated data sets with different sample size within different missing rate were generated and each of data sets were analysed by Cox regression and Bayesian Cox regression with informative prior. Secondly lung cancer data set as real data set was used for analysis. Consequently, using informative priors for variables with missing value solved the missing data problem.     

Flexibility Structure and Capacity Design with Human Resource Considerations

Most service systems consist of multidepartmental structures with multiskill agents that can deal with several types of service requests. The design of flexibility in terms of agents' skill sets and assignments of requests is a critical issue for such systems. The objective of this study was to identify preferred flexibility structures when demand is random and capacity is finite. We compare structures recommended by the flexibility literature to structures we observe in practice within call centers. To enable a comparison of flexibility structures under optimal capacity, the capacity optimization problem for this setting is formulated as a two‐stage stochastic optimization problem. A simulation‐based optimization procedure for this problem using sample‐path gradient estimation is proposed and tested, and used in the subsequent comparison of the flexibility structures being studied. The analysis illustrates under what conditions on demand, cost, and human resource considerations, the structures found in practice are preferred.