Optimal two treatment repeated measurement designs for three periods

Repeated Measurement Designs, with two treatments, n (experimental) units and p periods are examined, the two treatments are denoted A and B. The model with independent observations within and between treatment sequences is used. Optimal designs are derived for: (i) the difference of direct treatment effects and the difference of residual effects, (ii) the difference of direct treatment effects, and (iii) the difference of residual effects. We prove that for three periods when n is odd the optimal design in the three cases (i), (ii), and (iii) is determined by taking the sequences BAA and ABB in numbers differing by one. If n is even, the optimal design in cases (i), (ii), and (iii) is again the same, by taking the sequences ABB and BAA in equal numbers. In case (i), for n even or odd, in the optimal design there is no correlation between the two estimated parameters. For n even, case (i) was solved by Cheng and Wu in 1980. The above imply that with two treatments in practice are preferable to use three periods instead of two.     

Extension and necessity of Cheng and Wu conditions

Repeated Measurement Designs, with two treatments, n (experimental) units and p periods are examined. The model examined is with uncorrelated observations following a continuous distribution with constant variance and the parameters of interest are (i) the difference of direct effects and (ii) the difference of residual effects. In this paper (a) the difference of Universal optimality and Φ-optimality is clarified and (b) the sufficient conditions of Cheng and Wu (1980) are extended to include the case n=2 mod 4, p even, (c) also it is shown that these conditions are also necessary for Φ-optimality for estimating direct as well as residual effects, and (d) a method is proposed to construct Φ-optimal designs and examples are given when n even and p=3, n=0 mod 4 and p=4, n=2 mod 4 and p=4. In the last case the estimated parameters in the optimal design are correlated.     

Some d-optimal weighing designs for n≡ (mod 4)

A number of D-optimal weighing designs are constructed with the help of block matrices. The D-optimal designs (n,k,s)=(19,13,10), (19,14,7), (19,14,8), (19,15,7), (19,15,8), (19,17,6), (19,18,6), (23,16,8), (23,17,8), (23,18,8), (4n?1,2n+3,(3n+4)/2), (4n?1,2n+4,n+3), (4n?1,2n+4,n+2) where n≡0 mod 4 and a skew H_n exists, (31,24,8), (31,25,8) and many others are constructed. A computer routine leading to locally D-optimal designs is presented.     

The exact D-optimal first order saturated design with 17 observations

The exact D-optimal first order saturated design with 17 observations is given. The upper bound of the determinant of the information matrix is established and a design attaining this value is constructed. The information matrix is proved to be unique and the optimal design contains the B.I.B. design (16, 16, 6, 6, 2).