Effects of testosterone replacement therapy withdrawal and re-treatment in hypogonadal elderly men upon obesity,voiding function and prostate safety parameters

Whether testosterone replacement therapy (TRT) is a lifelong treatment for men with hypogonadism remains unknown. We investigated long-term TRT and TRT withdrawal on obesity and prostate-related parameters. Two hundred and sixty-two hypogonadal patients (mean age 59.5) received testosterone undecanoate in 12-week intervals for a maximum of 11 years. One hundred and forty-seven men had TRT interrupted for a mean of 16.9 months and resumed thereafter (Group A). The remaining 115 patients were treated continuously (Group B). Prostate volume, prostate-specific antigen (PSA), residual voiding volume, bladder wall thickness, C-reactive protein (CRP), aging male symptoms (AMS), International Index of erectile function – erectile function (IIEF-EF) and International Prostate Symptoms Scores (IPSS) were measured over the study period with anthropometric parameters of obesity, including weight, body mass index (BMI) and waist circumference. Prior to interruption, TRT resulted in improvements in residual voiding volume, bladder wall thickness, CRP, AMS, IIEF-EF, IPSS and obesity parameters while PSA and prostate volume increased. TRT interruption reduced total testosterone to hypogonadal levels in Group A and resulted in worsening of obesity parameters, AMS, IPSS, residual voiding volume and bladder wall thickness, IIEF-EF and PSA while CRP and prostate volume were unchanged until treatment resumed whereby these effects were reversed. TRT interruption results in worsening of symptoms. Hypogonadism may require lifelong TRT.     

Competition, substitution, or discretion: an analysis of Palestinian and foreign guest workers in the Israeli labor market

This paper investigates the effects of foreign workers on labor market outcomes for Palestinian workers in the Israeli labor market. The paper utilizes a micro-dataset on the Palestinian labor force combined with time-series data on foreign workers in Israel. The data covers the period 1999–2003, a period in which Israel enforced a strict closure on labor (and goods) movement, particularly in 2001 and 2002. The evidence suggests that foreign workers in Israel do not affect Palestinian employment; however, an increase in the number of foreign workers in Israel tends to reduce Israeli wages paid to Palestinian workers from the Gaza Strip. The Israeli closure policy appears to be the main cause for the substantial reduction in long-run Palestinian employment levels in Israel, not the presence of foreign workers.     

An algorithm to dynamically adjust the number of Kanbans in stochastic processing times and variable demand environment

In a real-life environment, the just-in-time JIT system is subjected to various types of uncertainties such as stochastic processing times and variable demand. Since, JIT was only meant to operate in a deterministic environment, its performance is seriously affected by variations in processing times and demand. In this paper, a newly developed Kanban system is presented which uses an algorithm to dynamically and systematically manipulate the number of Kanbans in order to offset the blocking and starvation caused by the said uncertainties during a production cycle. The new system is termed a flexible Kanban system FKS . The steps of the algorithm are detailed and the effectiveness of FKS is demonstrated using an example model. For the example model, the solution procedure, results and a discussion are presented.     

How does information sharing affect first-tier suppliers’ flexibility? Evidence from the automotive industry in Sweden

This study addresses the critical research issue of how supplier delivery performance can be enhanced by integrating information sharing into volume and delivery flexibility. This study developed a research model to relate information sharing on demand forecasts and inventory data between original equipment manufacturers (OEMs) and first-tier suppliers. Based on a sample of 52 suppliers from automotive industry in Sweden, partial least squares structural equations modelling (PLS-SEM) was used to assess the model. The results confirm that sharing demand forecasts is a key enabler of supplier volume and delivery flexibility while sharing inventory data is not. The study contributes to enlarging the knowledge about supply chain management from the suppliers’ perspective. It also contributes to knowledge by validating the conceptual model and operationalisation of constructs. The study also has practical contribution in which management should focus on improving communication and collaboration practices with OEMs for effective sharing of demand forecasts.     

Signaling probabilities in ambiguity: who reacts to vague news?

Theory and Decision - Ambiguity affects decisions of people who exhibit a distaste of and require a premium for dealing with it. Do ambiguity-neutral subjects completely disregard ambiguity and...     

Selected singular-generalized-hyperbolic distributions with applications to order statistics and reliability

In this paper, the truncated version of the selected multivariate generalized-hyperbolic distributions is introduced. Considering special truncations, the joint distribution of the consecutive order statistics from the multivariate generalized-hyperbolic (GH) distribution is derived. It is shown that this joint distribution can be expressed as mixtures of the truncated selected-GH distributions. All of these truncated distributions are expressed as the selected singular-GH distributions. These results are used to obtain some expressions for the reliability measures such as mean residual life time, mean inactivity time and regression mean residual life for k-out-of-n systems.     

FINANCE-INEQUALITY NEXUS: THE LONG AND THE SHORT OF IT

Financial development affects income inequality differently in the short and in the long term. Investigating OECD countries from 1870–2011, we find in the short run, an improvement in financial development tends to reduce inequality, while in the long run, more finance contributes to more inequality. The short-run effect concurs with theories advocating financial development increases the availability of financial services, primarily for the poor. However, this effect becomes nil within a few years. Results thus imply that policies aimed at reducing inequality through improving access of the poor to finance need to be carefully designed to ensure longevity of impact. (JEL O15, O16, D31, G20, E44)     

Stochastic Liénard Equations with Random Switching and Two-time Scales

This article is devoted to the study of stochastic Liénard equations with random switching. The motivation of our study stems from modeling of complex systems in which both continuous dynamics and discrete events are present. The continuous component is a solution of a stochastic Liénard equation and the discrete component is a Markov chain with a finite state space that is large. A distinct feature is that the processes under consideration are time inhomogeneous. Based on the idea of nearly decomposability and aggregation, the state space of the switching process can be viewed as “nearly decomposable” into l subspaces that are connected with weak interactions among the subspaces. Using the idea of aggregation, we lump the states in each subspace into a single state. Considering the pair of process (continuous state, discrete state), under suitable conditions, we derive a weak convergence result by means of martingale problem formulation. The significance of the limit process is that it is substantially simpler than that of the original system. Thus, it can be used in the approximation and computation work to reduce the computational complexity.     

Error variance function estimation in nonparametric regression models

In this article, a new class of variance function estimators is proposed in the setting of heteroscedastic nonparametric regression models. To obtain a variance function estimator, the main proposal is to smooth the product of the response variable and residuals as opposed to the squared residuals. The asymptotic properties of the proposed methodology are investigated in order to compare its asymptotic behavior with that of the existing methods. The finite sample performance of the proposed estimator is studied through simulation studies. The effect of the curvature of the mean function on its finite sample behavior is also discussed.     

Assessing the Awareness of Egyptian Medical Students about Responsible Conduct of Research and Research Ethics: Impact of an Educational Campaign

This is a quasi-experimental pre-post assessment study utilizing an anonymous self-administered questionnaire to assess Egyptian medical students’ awareness about responsible conduct of research (RCR) and research ethics. Students’ were assessed before and after an RCR awareness campaign. Our results showed that most of the pre-campaign respondents were not familiar with the basic principles and terms of RCR. An increase in the awareness about RCR across all discussed topics was noted following the campaign. We concluded that an educational awareness campaign is effective in increasing medical students’ awareness about RCR and should be incorporated into current medical school curricula in Egypt.