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Morgan A. Bishop Anthony J. Macula Thomas E. Renz Vladimir V. Ufimtsev 《Journal of Combinatorial Optimization》2008,15(1):7-16
Classical group testing (CGT) is a widely applicable biotechnical technique used to identify a small number of distinguished
objects from a population when the presence of any one of these distinguished objects among a group of others produces an observable result. This paper discusses a variant of CGT called group testing for disjoint pairs (GTAP). The difference between the two is that in GTDP, the distinguished items are pairs from, not individual objects in,
the population. There are several biological examples of when this abstract model applies. One biological example is DNA hybridization.
The presence of pairs of hybridized DNA strands can be detected in a pool of DNA strands. Another situation is the detection
of binding interactions between prey and bait proteins. This paper gives a random pooling method, similar in spirit to hypothesis
testing, which identifies pairs of objects from a population that collectively have an observable function. This method is
simply to apply, achieves good results, is amenable to automation and can be easily modified to compensate for testing errors.
M.A. Bishop is supported by AFOSR FA8750-06-C-0007.
A.J. Macula is supported by NSF-0436298, AFOSR FA8750-06-C-0007. 相似文献
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吴益和 《上海理工大学学报(社会科学版)》1992,(1)
本文首次提出了确定溶液含二齿配体的配合物几何顺反异构体构型的新方法,定义了三元配合物MLL′(或ML_2)中ML与ML′(或ML)二跃迁偶极矩分向量之间的夹角θ,作为该配合物中配体L与L′(或L)之间几何因子的量度,当θ≤90°,为顺式异构体;当θ≥120°,为反式异构体;当90°<0<120°,居于顺反异构体之间。我们把单齿配体配合物顺反异构体的定义推广到含两个二齿配体的配合物。而且对配合物内配体之间的空间相对位置作了近似定量化的描述。 相似文献
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