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Morgan A. Bishop Anthony J. Macula Thomas E. Renz Vladimir V. Ufimtsev 《Journal of Combinatorial Optimization》2008,15(1):7-16
Classical group testing (CGT) is a widely applicable biotechnical technique used to identify a small number of distinguished
objects from a population when the presence of any one of these distinguished objects among a group of others produces an observable result. This paper discusses a variant of CGT called group testing for disjoint pairs (GTAP). The difference between the two is that in GTDP, the distinguished items are pairs from, not individual objects in,
the population. There are several biological examples of when this abstract model applies. One biological example is DNA hybridization.
The presence of pairs of hybridized DNA strands can be detected in a pool of DNA strands. Another situation is the detection
of binding interactions between prey and bait proteins. This paper gives a random pooling method, similar in spirit to hypothesis
testing, which identifies pairs of objects from a population that collectively have an observable function. This method is
simply to apply, achieves good results, is amenable to automation and can be easily modified to compensate for testing errors.
M.A. Bishop is supported by AFOSR FA8750-06-C-0007.
A.J. Macula is supported by NSF-0436298, AFOSR FA8750-06-C-0007. 相似文献
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Group testing, sometimes called pooling design, has been applied to a variety of problems such as blood testing, multiple
access communication, coding theory, among others. Recently, screening experiments in molecular biology has become the most
important application. In this paper, we review several models in this application by focusing on decoding, namely, giving
a comparative study of how the problem is solved in each of these models. 相似文献
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