西部产业集群发展的制度分析

从制度上看,区域产业集群发展具有自发性或诱致性、以市场制度为基础密切联系而形成核心竞争力、根植性等制度特征。西部产业集群发展,具有优惠的区域政策和制度后发优势,但也面临一定的正式制度和非正式制度约束,如与市场经济相左的思想道德观念、偏重自然资源的路径依赖、地方政府职能的错位、中央投资体制分割,等等。针对这些约束,必须采取相应的制度创新。     

Bayesian inference for a discretely observed stochastic kinetic model

The ability to infer parameters of gene regulatory networks is emerging as a key problem in systems biology. The biochemical data are intrinsically stochastic and tend to be observed by means of discrete-time sampling systems, which are often limited in their completeness. In this paper we explore how to make Bayesian inference for the kinetic rate constants of regulatory networks, using the stochastic kinetic Lotka-Volterra system as a model. This simple model describes behaviour typical of many biochemical networks which exhibit auto-regulatory behaviour. Various MCMC algorithms are described and their performance evaluated in several data-poor scenarios. An algorithm based on an approximating process is shown to be particularly efficient.     

系统科学在大型技术装备项目中的应用

本文论述了系统科学的理论和方法在大型技术装备项目管理中的应用和发展,着重介绍了项目规划的方案优选和项目管理组织体系、计划控制系统,质量控制系统、项目管理信息系统。从这个项目管理系统的总体看,随着加工的进展,系统内信息不断扩大和加深,形成生产管理信息回路,而且采用人-机结合的信息网络,为配合项目管理发挥了重要作用。     

具有三次代数曲线解的五次系统的极限环

本文利用Maple软件强大的符号计算能力,得到了以 y=ax~3+bx~2+cx+d 为解的平面五次多项式系统的特征,由此证明了该系统在奇点的邻域内可以存在极限环。     

The impact of P.L. 93-641, the National Health Planning and Resources Development Act, upon health and mental health programming

Federal legislation regarding health care in the U.S. has increased rapidly in the past few years. A major law with potential far-reaching effects was enacted as a result of increasing legislation and rising health care costs. This law,The National Health Planning and Resources Development Act,has created a network of over 200 local, mostly nongovernment units, called health systems agencies. These agencies are responsible for areawide health planning, plan implementation, review and approval of federal health care expenditures for local programs, and facilities review. They will affect health and mental health programs at the local level. The article is directed to local health and mental health care providers who will, of necessity, deal directly with the local HSA's.     

The utilization of prevailing evaluation policy in the selection of performance measures

This study considers the problem of inferring a functional evaluation criterion from existing performance measure policies. The objective is to develop a rational basis by which to adaptively evaluate a current best set of performance measures from alternative sets. The analysis is based on a matrix approach for relating system characteristics to performance measures across a set of activities. A procedure for ranking measure combinations which are candidate implementation alternatives is devised using this matrix representation and cost information. An example illustrating the procedure is presented.     

Mixed integer (0–1) fractional programming for decision support in paper production industry

This paper presents an effective and efficient method for solving a special class of mixed integer fractional programming (FP) problems. We take a classical reformulation approach for continuous FP as a starting point and extend it for solving a more general class of mixed integer (0–1) fractional programming problems.To stress the practical relevance of the research we focus on a real-life application in paper production industry. The constantly advancing physical knowledge of large scale pulp and paper production did have a substantial impact on an existing DSS in which mixed integer (0–1) fractional programming is introduced. We show that the motivation to solve a real-life fractional programming problem can provide the basis for a new approach in a new context that has an added value of its own, even outside the given application area. We describe the main characteristics of the DSS, the necessity to develop a non-iterative solution procedure and demonstrate both the effectiveness and efficiency of the proposed approach from practical data sets.     

Extending systems thinking in planning and evaluation using group concept mapping and system dynamics to tackle complex problems

Group concept mapping (GCM) has been successfully employed in program planning and evaluation for over 25 years. The broader set of systems thinking methodologies (of which GCM is one), have only recently found their way into the field. We present an overview of systems thinking emerging from a system dynamics (SD) perspective, and illustrate the potential synergy between GCM and SD. As with GCM, participatory processes are frequently employed when building SD models; however, it can be challenging to engage a large and diverse group of stakeholders in the iterative cycles of divergent thinking and consensus building required, while maintaining a broad perspective on the issue being studied. GCM provides a compelling resource for overcoming this challenge, by richly engaging a diverse set of stakeholders in broad exploration, structuring, and prioritization. SD provides an opportunity to extend GCM findings by embedding constructs in a testable hypothesis (SD model) describing how system structure and changes in constructs affect outcomes over time. SD can be used to simulate the hypothesized dynamics inherent in GCM concept maps. We illustrate the potential of the marriage of these methodologies in a case study of BECOMING, a federally-funded program aimed at strengthening the cross-sector system of care for youth with severe emotional disturbances.     

Smoking during pregnancy,stigma and secrets: Visual methods exploration in the UK

BackgroundMoral judgements are commonly directed towards mothers through reference to health behaviour in pregnancy, and working-class mothers are particularly subject to this moral gaze.AimTo gain an in-depth understanding of the health issues affecting 10 low income pregnant women from deprived areas of south Wales, UK.MethodsParticipants completed visual activities (timelines, collaging or thought bubbles and dyad sandboxing) prior to each interview. Participants’ visual representations were used in place of a topic guide, to direct the interview. Guided by feminist principles, 28 interviews were completed with 10 women. Data were analysed thematically.FindingsSmoking was discussed at length during interviews, and this paper focuses on this issue alone. Five of the participants had smoked during pregnancy. Negative reactions were directed towards pregnant women who smoked in public, resulting in maternal smoking being undertaken in private. Participants also reported awkward relationships with midwives and other health professionals, including receipt of public health advice in a judgemental tone.DiscussionSmoking during pregnancy is a particularly demonised and stigmatised activity. This stigma is not always related to the level of risk to the foetus, and instead can be seen as a moral judgement about women. We urgently need to move from individualised neo-liberal discourses about the failure of individual smokers, to a more socio-ecological view which avoids victim blaming.ConclusionStigma from friends, family, strangers and health professionals may lead to hidden smoking. This is a barrier to women obtaining evidence based stop smoking support.     

Application of load-oriented manufacturing control in industry

This paper deals with multi-stage lotsizing models for imperfect production processes. The effect of imperfect quality on lotsizing decisions and effect ofinspection errorsare taken into consideration in the proposed models. Numerical examples are presented for illustration purposes. The developed models are very helpful for justifying quality assurance and quality improvement efforts.