Analysing truncated data with semiparametric transformation models

Left-truncation often arises when patient information, such as time of diagnosis, is gathered retrospectively. In some cases, the distribution function, say G(x), of left-truncated variables can be parameterized as G(x; θ), where θ∈Θ?R^q and θ is a q-dimensional vector. Under semiparametric transformation models, we demonstrated that the approach of Chen et al. (Semiparametric analysis of transformation models with censored data. Biometrika. 2002;89:659–668) can be used to analyse this type of data. The asymptotic properties of the proposed estimators are derived. A simulation study is conducted to investigate the performance of the proposed estimators.     

Bibliographical Note

In England in the Middle Ages, inheritance data were recorded of tenants who owned land from the Crown. Male adult mortality is estimated from these data. A tenant was allowed to sell his land. Only if he still owned land at death, his age at death was observed; so death was right censored by sell of all the land. The censoring times are not observed because sell of land was never recorded. This makes the estimation problem nonstandard. The age at death is left truncated, because a future tenant had to survive his testator to inherit the title “tenant” and the land and to appear in the dataset. Life span distribution and life expectancy are estimated before and during the outbreak of the Black Death, which started in 1348.     

The Seeming Paradox of Increasing Mortality in a Highly Industrialized Nation: The Example of the Soviet Union

A discussion of the surprising phenomenon of declining life expectancy in a highly developed country such as the Soviet Union during the 1970s shows that this result was probably due only in a small part to ‘true’ causal changes in the conditions of living. At least equally important is the weaknesses of the measure of life expectancy by itself. The logical difference between period and cohort measurement is one part of the explanation. Another important factor is the adverse selection of risks by war, which makes international and intertemporal comparisons less valuable. Factors like population redistribution or changes in the registration also contribute to the explanation. Thus; life expectancy (in particular period life expectancy) should not, without closer consideration, be accepted as a reliable indicator of human welfare under such circumstances.     

Copula-graphic estimation with left-truncated and right-censored data

In Survival Analysis and related fields of research right-censored and left-truncated data often appear. Usually, it is assumed that the right-censoring variable is independent of the lifetime of ultimate interest. However, in particular applications dependent censoring may be present; this is the case, for example, when there exist several competing risks acting on the same individual. In this paper we propose a copula-graphic estimator for such a situation. The estimator is based on a known Archimedean copula function which properly represents the dependence structure between the lifetime and the censoring time. Therefore, the current work extends the copula-graphic estimator in de Uña-Álvarez and Veraverbeke [Generalized copula-graphic estimator. Test. 2013;22:343–360] in the presence of left-truncation. An asymptotic representation of the estimator is derived. The performance of the estimator is investigated in an intensive Monte Carlo simulation study. An application to unemployment duration is included for illustration purposes.     

Standardized Martingale Residuals Applied to Grouped Left Truncated Observations of Dementia Cases

The use of martingale residuals have been proposed for modelchecking and also to get a non-parametric estimate of the effectof an explanatory variable. We apply this approach to an epidemiologicalproblem which presents two characteristics: the data are lefttruncated due to delayed entry in the cohort; the data are groupedinto geographical units (parishes). This grouping suggests anatural way of smoothing the graph of residuals which is to computethe sum of the residuals for each parish. It is also naturalto present a graph with standardized residuals. We derive thevariances of the estimated residuals for left truncated datawhich allows computing the standardized residuals. This methodis applied to the study of dementia in a cohort of old people,and to the possible effect of the concentration of aluminum andsilica in drinking water on the risk of developing dementia.     

Logspline Density Estimation under Censoring and Truncation

ABSTRACT. In this paper we consider logspline density estimation for data that may be left-truncated or right-censored. For randomly left-truncated and right-censored data the product-limit estimator is known to be a consistent estimator of the survivor function, having a faster rate of convergence than many density estimators. The product-limit estimator and B-splines are used to construct the logspline density estimate for possibly censored or truncated data. Rates of convergence are established when the log-density function is assumed to be in a Besov space. An algorithm involving a procedure similar to maximum likelihood, stepwise knot addition, and stepwise knot deletion is proposed for the estimation of the density function based upon sample data. Numerical examples are used to show the finite-sample performance of inference based on the logspline density estimation.     

Convergence rate of the kernel regression estimator for associated and truncated data

This paper studies the behaviour of the kernel estimator of the regression function for associated data in the random left truncated model. The uniform strong consistency rate over a real compact set of the estimate is established. The finite sample performance of the estimator is investigated through extensive simulation studies.     

Response-based multiple imputation method for minimizing the impact of covariate detection limit in logistic regression

Abstract

Presence of detection limit (DL) in covariates causes inflated bias and inaccurate mean squared error to the estimators of the regression parameters. This paper suggests a response-driven multiple imputation method to correct the deleterious impact introduced by the covariate DL in the estimators of the parameters of simple logistic regression model. The performance of the method has been thoroughly investigated, and found to outperform the existing competing methods. The proposed method is computationally simple and easily implementable by using three existing R libraries. The method is robust to the violation of distributional assumption for the covariate of interest.     

Estimation in the Cox proportional hazards model with doubly censored and truncated data

In longitudinal studies, the proportional hazard model is often used to analyse covariate effects on the duration time, defined as the elapsed time between the first and second event. In this article, we consider the situation when the first event suffers partly interval-censoring and the second event suffers left-truncation and right-censoring. We proposed a two-step estimation procedure for estimating the regression coefficients of the proportional model. A simulation study is conducted to investigate the performance of the proposed estimator.