Statistical testing strategies for assessing treatment efficacy and marker accuracy in phase III trials

When a candidate predictive marker is available, but evidence on its predictive ability is not sufficiently reliable, all‐comers trials with marker stratification are frequently conducted. We propose a framework for planning and evaluating prospective testing strategies in confirmatory, phase III marker‐stratified clinical trials based on a natural assumption on heterogeneity of treatment effects across marker‐defined subpopulations, where weak rather than strong control is permitted for multiple population tests. For phase III marker‐stratified trials, it is expected that treatment efficacy is established in a particular patient population, possibly in a marker‐defined subpopulation, and that the marker accuracy is assessed when the marker is used to restrict the indication or labelling of the treatment to a marker‐based subpopulation, ie, assessment of the clinical validity of the marker. In this paper, we develop statistical testing strategies based on criteria that are explicitly designated to the marker assessment, including those examining treatment effects in marker‐negative patients. As existing and developed statistical testing strategies can assert treatment efficacy for either the overall patient population or the marker‐positive subpopulation, we also develop criteria for evaluating the operating characteristics of the statistical testing strategies based on the probabilities of asserting treatment efficacy across marker subpopulations. Numerical evaluations to compare the statistical testing strategies based on the developed criteria are provided.     

Teaching technologies for immigrant children: an exploratory study of elementary school teachers in Russia*

ABSTRACT

Educational institutions are an important setting where psychological, pedagogical, sociocultural, and language adaptation of immigrant children occurs. A number of teaching strategies, practices, approaches, and methods have been described in the literature. In the Russian context, such strategies have been called ‘technologies’. The purpose of the present exploratory study was to describe teaching technologies used by teachers in Russia when working with immigrant students in elementary schools. Responses of forty-five elementary school teachers to open-ended questions describing technologies they use when teaching children with migration backgrounds were analyzed using content analysis. Findings suggest that Russian elementary school teachers used ethno-cultural group, communicative technologies, games, individualized instruction, and differentiated teaching. Many approaches mentioned can be used inclusively with groups of immigrant and non-immigrant students. Importantly, while teachers supplemented classroom instruction with additional Russian language lessons, none mentioned specific techniques for teaching Russian as a non-native language. These findings are discussed in relation to teaching strategies described in the international literature focused on migrant students. Finally, implications for further research are discussed.     

The impact of social power and influence on the implementation of innovation strategies: A case study of a UK mega infrastructure construction project

Influence plays a key role in reaching consensus among multiple actors involved in project-based decision-making processes. While prior literature devotes considerable attention to describing influence, little attention has been paid to influence at the individual level of the strategic project manager within the context of megaprojects. This research intended to fill this knowledge gap by identifying and describing the influence strategies that a strategic project manager applies when implementing innovation strategies on megaprojects. A qualitative case study was used to examine the complex social processes involved in a major UK capital investment programme. The findings underline a critical subset of influence strategies, notably higher-management support, inspirational appeal and bargaining. The study proposes a utilitarian structure of social power comprising selective, supportive and executory power bases.     

Challenges to Connecting Sociology and Service Learning

Service-learning programs are not free from challenges brought about by lack of financial support, lack of widespread commitment from professors, community agencies, and recipients of service, and lack of knowledge and insight in students directly involved in such programs. While service-learning initiatives and programs serve positive functions for organizations and individuals, rhetorical accolades for service learning can distort or omit the realities of program implementation and sustained delivery. This paper specifically explores the following challenges connected to service-learning programs: (1) pedagogical difficulties; (2) student limitations; (3) time constraints; and (4) community cooperation.     

韩国大企业集团的海外扩张战略

自 70年代以来 ,韩国政府通过采取出口导向战略扶持大企业进军海外市场 ,带动了韩国经济的发展。韩国在短短的几十年里由一个农业国变成了一个新兴的工业化国家 ,经济总量居亚洲第三。在韩国经济快速发展中 ,大企业的强力出口、大举投资的海外扩张战略功不可没     

体裁分析在商务语篇教学中的作用

文章介绍了近年来在美国、澳大利亚等国盛行的“体裁教学法”,评价了体裁和体裁分析理论,阐述了体裁分析的发展与特色,探讨了体裁分析法在商务语篇教学中的作用。     

CRM的理念与实施中关键因素分析

随着市场环境、竞争环境的快速变化 ,企业的管理理念、服务观念开始发生重大转变 ,使得CRM(CustomerRelationshipManagement,客户关系管理 )成为当前热点。本文试从CRM在国内外的应用情况、CRM体现的管理理念、服务宗旨以及实施中应考虑的一些重要因素进行分析     

森林旅游业实施绿色营销的研究

深刻分析了传统市场营销策略对森林旅游业所产生的负面影响。阐述了森林旅游业实施绿色营销的基本原则 ,并提出相应的实施对策。这些对策主要包括努力塑造绿色企业形象 ,建立新型的绿色管理模式 ,大力开发森林旅游绿色产品和生态道德建设     

对车险改革后保险营销的浅析

在车辆保险条款费率改革之后的车险市场上,现实状况却与预计效果相差甚远。其主要原因是,对保险营销战略的忽视,没有以相应的保险营销战略为指导,使得营销战术在操作过程中显得盲目而跟从。针对以上问题,我们首先要做的是树立正确的保险营销观念,即重新审视营销战略在车辆保险中的作用,并在此基础上建立广义的产品观念;同时注重服务在车险营销中的作用;有效地进行市场细分和市场选择;最后对车险营销战略的具体实施即营销战术提出建议。     

高新技术产品的市场营销策略

高新技术产品能否在激烈的国际竞争中占有一定的市场份额 ,这不仅仅决定于一个国家、一个企业的技术实力 ,而且与成熟而有效的营销策略密切相关。本文从高新技术产品的分类和特征入手 ,分析和研究了高新技术产品的营销策略