Sympathy and the Value of Health: The Spill-over Effects of Migraine on Household Well-being

In this paper a model of life satisfactionmeasurement is formulated to calculatehappiness interdependencies. The model isapplied to estimate the spill-over effects ofmigraine headache on well-being. It is foundthat women are more compassionate thanmen. The results also show that ignoringhappiness interdependencies of migraineheadache underestimates the effects of migraineheadache on well-being.     

Statistical models for the analysis of controlled trials on acute migraine

Specific efficacy criteria were defined by the International Headache Society for controlled clinical trials on acute migraine. They are derived from the pain profile and the timing of rescue medication intake. We present a methodology to improve the analysis of such trials. Instead of analysing each endpoint separately, we model the joint distribution and derive success rates in any criteria as predictions. We use cumulative regression models for each response at a time and a multivariate normal copula to model the dependence between responses. Parameters are estimated using maximum likelihood. Benefits of the method include a reduction in the number of tests performed and an increase in their power. The method is well suited to dose–response trials from which predictions can be used to select doses and optimize the design of subsequent trials. More generally, our method permits a very flexible modelling of longitudinal series of ordinal data. Copyright © 2003 John Wiley & Sons, Ltd.     

Screens and teens with migraines: visually sensitive learners in contemporary digital classrooms

Technology-rich school classrooms incorporate digital media in the form of computers and interactive whiteboards into the visual learning environment. Whilst evidence-based research shows use of technology improves academic outcomes for high school students in general, there are limited data available on the consequences of digital media use for high school students with migraine. This article highlights the historical issues with light-emitting media, the physical parameters that are changed by adoption of these digital media into the classroom and some of the adverse effects caused by visual light stimulation. The article concludes by calling for further social research to better understand adjustments needed by students with migraine in the digital media classroom, and the policies needed to support image parameter guidelines for schools. In this article, the term visual light sensitivity refers to any student’s abnormal sensitivity to optically sighted light leading to negative responses, including that of migraine.     

A permutation‐based trend test for the analysis of a mechanistic animal migraine assay with a nonstandard design

The effect of a test compound on neurogenically induced vasodilation in marmosets was studied using a non‐standard experimental design with overlapping dosage groups and repeated measurements. In this study, the assumption that the data were normally distributed seemed inappropriate, so no traditional data analyses could be used. As an alternative, a new permutation trend test was designed based on the Jonckheere–Terpstra test statistic. This test protects the type I error without any further assumptions. Statistically significant differences in trend between treatment groups were detected. The effect of the compound was then shown across doses using subsequent Wilcoxon rank‐sum tests against ordered alternatives. In all, the permutation test proved quite useful in this context. This nonparametric approach to the analysis may easily be adapted to other applications. Copyright © 2005 John Wiley & Sons, Ltd.