Reducing sample size needed for cox-proportional hazards model analysis using more efficient sampling method

Abstract

In general, survival data are time-to-event data, such as time to death, time to appearance of a tumor, or time to recurrence of a disease. Models for survival data have frequently been based on the proportional hazards model, proposed by Cox. The Cox model has intensive application in the field of social, medical, behavioral and public health sciences. In this paper we propose a more efficient sampling method of recruiting subjects for survival analysis. We propose using a Moving Extreme Ranked Set Sampling (MERSS) scheme with ranking based on an easy-to-evaluate baseline auxiliary variable known to be associated with survival time. This paper demonstrates that this approach provides a more powerful testing procedure as well as a more efficient estimate of hazard ratio than that based on simple random sampling (SRS). Theoretical derivation and simulation studies are provided. The Iowa 65+ Rural study data are used to illustrate the methods developed in this paper.     

The effect of autocorrelation on the ewma maxmin tolerance limits

Amin et al. (1999) developed an exponentially weighted moving average (EWMA) control chart, based on the smallest and largest observations in each sample. The resulting plot of the extremes suggests that the MaxMin EWMA may also be viewed as smoothed tolerance limits. Tolerance limits are limits that include a specific proportion of the population at a given confidence level. In the context of process control, they are used to make sure that production will not be outside specifications. Amin and Li (2000) provided the coverages of the MaxMin EWMA tolerance limits for independent data. In this article, it is shown how autocorrelation affects the confidence level of MaxMin tolerance limits, for a specified level of coverage of the population, and modified smoothed tolerance limits are suggested for autocorrelated processes.     

17世纪朝鲜人流入东北及其对后金(清)社会的影响

本文从中朝关系史的角度,对17世纪朝鲜人流入中国东北的主要渠道及其对后金(清)社会农业、手工业、军事、文化等诸方面的影响作了简要的论述。     

Moving On From Supportive Housing (MOSH): Development and evaluation of a transitional skill-building curriculum for providers helping residents exit homeless services

This article describes the development and evaluation of MOSH (Moving On From Supportive Housing), a transitional skill-building curriculum for providers helping residents exit homeless services to mainstream housing without embedded supports. In this evaluation, we assess the feasibility, acceptability, fit, and potential efficacy of the MOSH curriculum to improve proximal provider-level outcomes, including self-efficacy to provide MOSH-related independent living skills and supports. Homeless-services providers (N = 49) from a range of programs and settings participated in the training. Findings from focus groups and pre- and posttest surveys indicate high levels of overall satisfaction with the training. The majority of trainees perceived the training to be useful to their work and potentially useful for service recipients, felt the training would fit well within their existing day-to-day work, and said they were very likely to use MOSH skills in such work. Statistically significant improvements in self-efficacy regarding all skills but one were also found. MOSH holds promise as an intervention that can enhance provider practice and promotion of independent living skills in homeless services. Although these initial findings on MOSH are encouraging, further research will be needed to evaluate provider knowledge gains and effective use of these skills in practice.     

Modified inference about the mean of the exponential distribution using moving extreme ranked set sampling

The maximum likelihood estimator (MLE) and the likelihood ratio test (LRT) will be considered for making inference about the scale parameter of the exponential distribution in case of moving extreme ranked set sampling (MERSS). The MLE and LRT can not be written in closed form. Therefore, a modification of the MLE using the technique suggested by Maharota and Nanda (Biometrika 61:601–606, 1974) will be considered and this modified estimator will be used to modify the LRT to get a test in closed form for testing a simple hypothesis against one sided alternatives. The same idea will be used to modify the most powerful test (MPT) for testing a simple hypothesis versus a simple hypothesis to get a test in closed form for testing a simple hypothesis against one sided alternatives. Then it appears that the modified estimator is a good competitor of the MLE and the modified tests are good competitors of the LRT using MERSS and simple random sampling (SRS).     

Estimation of the mean of the exponential distribution using moving extremes ranked set sampling

Moving Extremes Ranked Set Sampling (MERSS) is a useful modification of Ranked Set Sampling (RSS). Unlike RSS, MERSS allows for an increase of set size without introducing too much ranking error. The method is considered parametrically under exponential distribution. Maximum likelihood estimator (MLE), and a modified MLE are considered and their properties are studied. The method is studied under both perfect and imperfect ranking (with error in ranking). It appears that these estimators can be real competitors to the MLE using the usual simple random sampling (SRS).     

Bootstrap confidence regions computed from autoregressions of arbitrary order

Given a linear time series, e.g. an autoregression of infinite order, we may construct a finite order approximation and use that as the basis for confidence regions. The sieve or autoregressive bootstrap, as this method is often called, is generally seen as a competitor with the better-understood block bootstrap approach. However, in the present paper we argue that, for linear time series, the sieve bootstrap has significantly better performance than blocking methods and offers a wider range of opportunities. In particular, since it does not corrupt second-order properties then it may be used in a double-bootstrap form, with the second bootstrap application being employed to calibrate a basic percentile method confidence interval. This approach confers second-order accuracy without the need to estimate variance. That offers substantial benefits, since variances of statistics based on time series can be difficult to estimate reliably, and—partly because of the relatively small amount of information contained in a dependent process—are notorious for causing problems when used to Studentize. Other advantages of the sieve bootstrap include considerably greater robustness against variations in the choice of the tuning parameter, here equal to the autoregressive order, and the fact that, in contradistinction to the case of the block bootstrap, the percentile t version of the sieve bootstrap may be based on the 'raw' estimator of standard error. In the process of establishing these properties we show that the sieve bootstrap is second order correct.     

Estimation of the means of the bivariate normal using moving extreme ranked set sampling with concomitant variable

The estimation of the means of the bivariate normal distribution, based on a sample obtained using a modification of the moving extreme ranked set sampling technique (MERSS) is considered. The modification involves using a concomitant random variable. Nonparametric-type methods as well as the maximum likelihood estimation are considered. The estimators obtained are compared to their counterparts based on simple random sampling (SRS). It appears that the suggested estimators are more efficient. Also, MERSS with concomitant variable is easier to use in practice than the usual ranked set sampling (RSS) with concomitant variable. The issue of robustness of the procedure is addressed. Real trees data set is used for illustration.     

Conditional Information in Projections of Gaussian Vectors

Conditional information measures the information in a sample for an interest parameter in the presence of nuisance parameter. In the context of Gaussian likelihoods this paper first derives conditions under which a projection of the data may reduce conditional information to zero. These are then applied in the context of time series regressions, and inference on a covariance parameter, such as with either autoregressive or moving average errors. It is shown that regressing out very common regressors, such as a linear trend or dummy variable, can imply that conditional information is zero in the case of non-stationary autoregressions or non-invertible moving averages, respectively.     

Two new estimators of entropy for testing normality

ABSTRACT

We present two new estimators for estimating the entropy of absolutely continuous random variables. Some properties of them are considered, specifically consistency of the first is proved. The introduced estimators are compared with the existing entropy estimators. Also, we propose two new tests for normality based on the introduced entropy estimators and compare their powers with the powers of other tests for normality. The results show that the proposed estimators and test statistics perform very well in estimating entropy and testing normality. A real example is presented and analyzed.