2型糖尿病相关单核苷酸多态性c/t位点相似性分析

2型糖尿病（非胰岛素依赖型糖尿病）具有明显的家族遗传特点,但它的基因起源很大程度上并未得到深入了解。几种遗传因素共同影响提高了患2型糖尿病及相关代谢性疾病的风险性。通过对与2型糖尿病相关联的单核苷酸多态性位点（SNPs）做相似性分析来揭示2型糖尿病的基本机制,并作为标记来定位和识别与这一疾病相关的基因。     

Comparison of genomic sequences using the Hamming distance

The paper considers the problem of homogeneity among groups by comparison of genomic sequences. Some alternative procedures that attach less emphasis on the likelihood approach, and more on alternative measures that deal with similar homogeneity problems are considered here. On this approach, a one-sided hypothesis test is considered and the classical ANOVA decomposition can be directly adapted to sample measures based on the Hamming distance, without necessarily going through their second moments. Some results of U-statistics theory will be useful for the decomposition of the test statistic and to find its asymptotic distribution. An application of this test with real data is shown and the p-value of the test statistic is found via bootstrap resampling.