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Craig H. Mallinckrodt Christopher J. Kaiser John G. Watkin Michael J. Detke Geert Molenberghs Raymond J. Carroll 《Pharmaceutical statistics》2004,3(3):171-186
The last observation carried forward (LOCF) approach is commonly utilized to handle missing values in the primary analysis of clinical trials. However, recent evidence suggests that likelihood‐based analyses developed under the missing at random (MAR) framework are sensible alternatives. The objective of this study was to assess the Type I error rates from a likelihood‐based MAR approach – mixed‐model repeated measures (MMRM) – compared with LOCF when estimating treatment contrasts for mean change from baseline to endpoint (Δ). Data emulating neuropsychiatric clinical trials were simulated in a 4 × 4 factorial arrangement of scenarios, using four patterns of mean changes over time and four strategies for deleting data to generate subject dropout via an MAR mechanism. In data with no dropout, estimates of Δ and SEΔ from MMRM and LOCF were identical. In data with dropout, the Type I error rates (averaged across all scenarios) for MMRM and LOCF were 5.49% and 16.76%, respectively. In 11 of the 16 scenarios, the Type I error rate from MMRM was at least 1.00% closer to the expected rate of 5.00% than the corresponding rate from LOCF. In no scenario did LOCF yield a Type I error rate that was at least 1.00% closer to the expected rate than the corresponding rate from MMRM. The average estimate of SEΔ from MMRM was greater in data with dropout than in complete data, whereas the average estimate of SEΔ from LOCF was smaller in data with dropout than in complete data, suggesting that standard errors from MMRM better reflected the uncertainty in the data. The results from this investigation support those from previous studies, which found that MMRM provided reasonable control of Type I error even in the presence of MNAR missingness. No universally best approach to analysis of longitudinal data exists. However, likelihood‐based MAR approaches have been shown to perform well in a variety of situations and are a sensible alternative to the LOCF approach. MNAR methods can be used within a sensitivity analysis framework to test the potential presence and impact of MNAR data, thereby assessing robustness of results from an MAR method. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
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洋桔梗叶盘高频率不定芽诱导的初步研究 总被引:1,自引:0,他引:1
采用正交设计法研究了细胞分裂素ZT,生长素NAA,培养基pH值和光照强度对洋桔梗叶盘不定芽诱导的影响.结果表明,实验的4个因子对洋桔梗叶盘不定芽都具有极显著的诱导作用,最佳培养基和培养条件为:MS ZT 0.5 mg/L NAA 0.01 mg/L,培养基pH值为6.3,光照强度为3000 lx.该处理中每叶盘再生不定芽数平均达9.41个. 相似文献
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张若西 《西北大学学报(哲学社会科学版)》2003,33(1):114-117
美国南方流派的代表作家威廉·福克纳是一位实验性的作家,在他的文学生涯中,他做过多种尝试,他的早期长篇小说《我弥留之际》是其中非常重要的一次。这部作品的创作思想显示福克纳在上世纪30年代从人道主义向自然主义迈进。 相似文献
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本文阐述了期货市场法律规范的基本原则和主要功能,介绍了我国期货市场的近期发展与法规现状,并对我国期贷市场法律规范的基本原则与体系设置作了探讨。 相似文献
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逆向物流及其整合分析 总被引:9,自引:0,他引:9
温承革 《苏州科技学院学报(社会科学版)》2003,20(4):18-21
逆向物流是物流管理的一个新的领域,已经引起理论界和企业界越来越多的关注。逆向物流可以降低企业成本,提高顾客满意度,并最终提升企业的竞争力,这对我国企业实践具有重要意义。 相似文献
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Nonlinguistic communication is typically proposed to convey representational messages, implying that particular signals are associated with specific signaler emotions, intentions, or external referents. However, common signals produced by both nonhuman primates and humans may not exhibit such specificity, with human laughter for example showing significant diversity in both acoustic form and production context. We therefore outline an alternative to the representational approach, arguing that laughter and other nonlinguistic vocalizations are used to influence the affective states of listeners, thereby also affecting their behavior. In the case of laughter, we propose a primary function of accentuating or inducing positive affect in the perceiver in order to promote a more favorable stance toward the laugher. Two simple strategies are identified, namely producing laughter with acoustic features that have an immediate impact on listener arousal, and pairing these sounds with positive affect in the listener to create learned affective responses. Both depend on factors like the listener's current emotional state and past interactions with the vocalizer, with laughers predicted to adjust their sounds accordingly. This approach is used to explain findings from two experimental studies that examined the use of laughter in same-sex and different-sex dyads composed of either friends or strangers, and may be applicable to other forms of nonlinguistic communication. 相似文献
8.
Outlier detection algorithms are intimately connected with robust statistics that down‐weight some observations to zero. We define a number of outlier detection algorithms related to the Huber‐skip and least trimmed squares estimators, including the one‐step Huber‐skip estimator and the forward search. Next, we review a recently developed asymptotic theory of these. Finally, we analyse the gauge, the fraction of wrongly detected outliers, for a number of outlier detection algorithms and establish an asymptotic normal and a Poisson theory for the gauge. 相似文献
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基于"前向联系增加值出口"方法,测算了1995-2011年中国服务业细分产业层面及按要素密集度特征分类层面的显性比较优势指数(RCA_F),并同基于"总出口"1的比较优势指数(RCA)进行了比较。研究发现,中国在全球价值链分工中,比较优势集中在资本密集型服务业领域,且实现了比较劣势向比较优势的转变;劳动、知识密集型服务业及健康教育公共服务均尚未取得比较优势,但是有迹象表明三个领域的比较劣势有改善的趋势。与基于前向联系增加值出口核算结果相比,基于总出口核算结果"高估"了劳动密集型产业的比较优势,其中对建筑业和零售贸易两个部门的估计偏差最大;同时,在资本、知识密集型两个领域存在不同程度的"低估"现象。 相似文献
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