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1.
Stephen J. Ruberg Frank E. Harrell Jr. Margaret Gamalo-Siebers Lisa LaVange J. Jack Lee Karen Price 《The American statistician》2019,73(1):319-327
ABSTRACTThe cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making. 相似文献
2.
针对我国政府、企业和银行等金融机构共同关注的债转股问题,基于债务协商谈判思想,建立部分债务股权互换模型,计算公司证券价格,探讨了债转股对公司价值、破产概率、破产损失成本和资本结构的影响,给出了银行等债权人愿意债转股的充分条件。结果表明:在事先破产清算协议贷款下,事后全部债转股总能提高公司股权价值,但并不一定能提高债券价值。只有其协商谈判能力满足一定条件,公司债权人才愿意事后选择债转股,实现帕累托改进、提高社会福利水平。其次,在公司股东协商谈判能力的一定范围内,部分债转股能提高公司价值,其最优转股债息比例随着公司资产风险的增大而增加。再次,债转股能降低公司破产风险和破产损失成本,但同时也提高了债券风险溢价。最后,随着股东谈判能力增强,最优协商转股债务比例、杠杆率都减少,而债券风险溢价增大。本文所得结果对我国政府、企业和银行如何实施债转股提供理论参考和实践指导。 相似文献
3.
David R. Bickel 《统计学通讯:理论与方法》2020,49(11):2703-2712
AbstractConfidence sets, p values, maximum likelihood estimates, and other results of non-Bayesian statistical methods may be adjusted to favor sampling distributions that are simple compared to others in the parametric family. The adjustments are derived from a prior likelihood function previously used to adjust posterior distributions. 相似文献
4.
Keisuke Himoto 《Risk analysis》2020,40(6):1124-1138
Post-earthquake fires are high-consequence events with extensive damage potential. They are also low-frequency events, so their nature remains underinvestigated. One difficulty in modeling post-earthquake ignition probabilities is reducing the model uncertainty attributed to the scarce source data. The data scarcity problem has been resolved by pooling the data indiscriminately collected from multiple earthquakes. However, this approach neglects the inter-earthquake heterogeneity in the regional and seasonal characteristics, which is indispensable for risk assessment of future post-earthquake fires. Thus, the present study analyzes the post-earthquake ignition probabilities of five major earthquakes in Japan from 1995 to 2016 (1995 Kobe, 2003 Tokachi-oki, 2004 Niigata–Chuetsu, 2011 Tohoku, and 2016 Kumamoto earthquakes) by a hierarchical Bayesian approach. As the ignition causes of earthquakes share a certain commonality, common prior distributions were assigned to the parameters, and samples were drawn from the target posterior distribution of the parameters by a Markov chain Monte Carlo simulation. The results of the hierarchical model were comparatively analyzed with those of pooled and independent models. Although the pooled and hierarchical models were both robust in comparison with the independent model, the pooled model underestimated the ignition probabilities of earthquakes with few data samples. Among the tested models, the hierarchical model was least affected by the source-to-source variability in the data. The heterogeneity of post-earthquake ignitions with different regional and seasonal characteristics has long been desired in the modeling of post-earthquake ignition probabilities but has not been properly considered in the existing approaches. The presented hierarchical Bayesian approach provides a systematic and rational framework to effectively cope with this problem, which consequently enhances the statistical reliability and stability of estimating post-earthquake ignition probabilities. 相似文献
5.
Yutaka Nakamura 《Journal of Risk and Uncertainty》1993,6(1):33-48
This article is concerned with thresholds of discrimination of preference judgments under uncertainty. We establish an axiomatic characterization for a threshold representation, where thresholds are represented by inexact measurement of subjective probabilities, i.e., upper and lower probabilities. Since upper and lower probabilities need not be additive, the representational form adopts the Choquet integration. 相似文献
6.
间接故意与过于自信的过失是犯罪构成中主观方面最容易混淆的两种罪过,本文对这两种罪过进行了系统的比较,并对两者的实际操作中所体现的矛盾进行了分析,最后文章对矛盾提出了解决的方案。 相似文献
7.
冯梦龙《山歌》的女性话语解析 总被引:1,自引:0,他引:1
肖燕芳 《齐齐哈尔大学学报(哲学社会科学版)》2002,(1):105-107
以女性视角来解读晚明时期的《山歌》,其充满一种女权主义的隐喻,是在封建伦理式微前夕男权中心的退位及女权意识的崛起在民间的映证。 相似文献
8.
按照主观违法论而加以建构的传统犯罪构成理论有别于按客观违法论建构的大陆法系犯罪论体系,两者有着不同的研究进路和研究方法。主观违法论强调有责之违法,行为人的主观罪过、客观的危害行为、刑事责任能力都是违法的构成要素,这种因人而异的违法观不能很好地为司法实践提供理论根据。从主观违法论立场出发,我们不可能从构成要件其中一个方面单独地判断违法性是否存在,传统犯罪构成理论将犯罪构成要件定位于反映行为社会危害性的事实特征,因此,犯罪构成只反映定罪结论,不反映定罪过程。 相似文献
9.
Owing to the extreme quantiles involved, standard control charts are very sensitive to the effects of parameter estimation and non-normality. More general parametric charts have been devised to deal with the latter complication and corrections have been derived to compensate for the estimation step, both under normal and parametric models. The resulting procedures offer a satisfactory solution over a broad range of underlying distributions. However, situations do occur where even such a large model is inadequate and nothing remains but to consider non- parametric charts. In principle, these form ideal solutions, but the problem is that huge sample sizes are required for the estimation step. Otherwise the resulting stochastic error is so large that the chart is very unstable, a disadvantage that seems to outweigh the advantage of avoiding the model error from the parametric case. Here we analyse under what conditions non-parametric charts actually become feasible alternatives for their parametric counterparts. In particular, corrected versions are suggested for which a possible change point is reached at sample sizes that are markedly less huge (but still larger than the customary range). These corrections serve to control the behaviour during in-control (markedly wrong outcomes of the estimates only occur sufficiently rarely). The price for this protection will clearly be some loss of detection power during out-of-control. A change point comes in view as soon as this loss can be made sufficiently small. 相似文献
10.
Summary Weak disintegrations are investigated from various points of view. Kolmogorov's definition of conditional probability is critically
analysed, and it is noted how the notion of disintegrability plays some role in connecting Kolmogorov's definition with the
one given in line with de Finetti's coherence principle. Conditions are given, on the domain of a prevision, implying the
equivalence between weak disintegrability and conglomerability. Moreover, weak sintegrations are characterized in terms of
coherence, in de Finetti's sense, of, a suitable function. This fact enables us to give, an interpretation of weak disintegrability
as a form of “preservation of coherence”. The previous results are also applied to a hypothetical inferential problem. In
particular, an inference is shown to be coherent, in the sense of Heath and Sudderth, if and only if a suitable function is
coherent, in de Finetti's sense.
Research partially supported by: M.U.R.S.T. 40% “Problemi di inferenza pura”. 相似文献