The impact of testosterone replacement therapy on glycemic control,vascular function,and components of the metabolic syndrome in obese hypogonadal men with type 2 diabetes

Objective: This study set out to assess effects of testosterone replacement therapy (TRT) on parameters of metabolic syndrome and vascular function in obese hypogonadal males with type 2 diabetes mellitus (DM2).

Study design: Fifty-five obese hypogonadal diabetic males on oral hypoglycemic treatment were enrolled into this one-year, double-blind, randomized, placebo-controlled clinical study. Group T (n?=?28) was treated with testosterone undecanoate (1000?mg i.m. every 10?weeks) while group P (n?=?27) received placebo.

Methods: Anthropometrical and vascular measurements – flow-mediated dilatation (FMD) and intima media thickness (IMT) – biochemical and hormonal blood sample analyses were performed at the start of the study and after one year. Derived parameters (BMI, HOMA-IR, calculated free testosterone (cFT) and bioavailable testosterone (BT)) were calculated.

Results: TRT resulted in reduction of HOMA-IR by 4.64?±?4.25 (p?p?p?=?.005).

Conclusion: TRT normalized serum testosterone levels, improved glycemic control and endothelial function while exerting no ill effects on the study population.     

由薄到厚 由厚到薄——素质塑造的机理探讨

素质塑造就是由薄到厚 ,由厚到薄。思与学是素质塑造的基本功夫。由薄到厚是知识的积累 ;由厚到薄是内化、超越、创造     

铸件壁厚对ZL101铝合金组织和力学性能的影响

本文针对壁厚不同的ZL101铝合金铸件,研究了合金组织中α(Al)和共晶Si的形貌、尺寸及分布状况,并对其力学性能进行了测试.试验结果表明,随着壁厚的减小,α(Al)晶粒不断细化,二次枝晶臂间距逐渐减小;共晶硅等效直径减小,且由长针片状变为细小颗粒状,分布更均匀;力学性能随壁厚的减小而提高.     

激光超声的光学零差探测

激光巨脉冲在金属铝块上产生超声波,由光学零差探测得到超声引起的后表面位移的波形。文中分析了探测信号与位移的关系,导出了系统灵敏度公式。用激光超声测得铝块厚度与实际值很好地吻合,同时测出了系统的最小可探测位移。     

直齿圆锥齿轮弧齿厚的计算

本文介绍利用球面渐开线方程计算圆锥齿轮背锥齿形弧齿厚的方法,并通过实例指出利用当量圆柱齿轮计算弧齿厚的理论误差。     

原发性高血压患者颈动脉内膜中层厚度与踝臂指数的相关性研究

目的探讨原发性高血压患者颈动脉内膜中层厚度（IMT）与踝臂指数（ABI）的关系。方法156例原发性高血压患者作为高血压组,137例健康体检者作为对照组,所有患者行双侧颈动脉内膜中层厚度（IMT）及踝臂指数（ABI）的测定。结果①高血压NIMT大于对照组（P〈0．05）,ABI小于对照组（P〈0．01）。（参高血压组IMT与ABI呈负相关（R〈0．01）,对照组二者无显著相关性（P〉0．05）。结论ABI可作为高血压患者颈动脉粥样硬化的指标,适合作为高血压人群常规筛查的手段。     

The impact of atherosclerosis on lower urinary tract function

Abstract

Objective: The current study was carried out to investigate the impact of atherosclerosis on lower urinary tract function in the male patients with lower urinary tract symptoms (LUTS).

Patients and methods: This prospective study evaluated 110 male patients aged 55–75 years who were presented with LUTS. All patients underwent general and local investigations. The atherosclerosis was assessed by ultrasound examination of the carotid artery. Patients then were divided into two groups: non-atherosclerosis group (Group 1) and atherosclerosis group (Group 2). The two groups were compared regarding voiding and storage parameters.

Results: Mean patient age were 67.9?±?5.9 years. The average age and number of Group 1 was 65.7?±?4.3, n?=?51. The average age and number of Group 2 was 68.7?±?5.3, n?=?59. There were no significant differences in age, prostate volume, blood pressure, International Prostate Symptom Score, Voiding symptom score and Storage symptom score between the two groups. Blood serum triglycerides were significantly lower in Group 1 than Group 2 while HDL cholesterol were significantly higher in Group 1 than Group 2 0.97?±?0.5 and 1.43?±?0.2?mmol/L, versus 1.46?±?0.7 and 1.28?±?0.3?mmol/L, respectively. Qmax denotes significant decrease in Group 2 compared with Group 1 12.5?±?6.3 versus 17.6?±?6.5, respectively (p?<?0.01). While in post-voiding residual urine, there was a significant increase in Group 2 compared with Group 1 82.2?±?15.4 versus 51.4?±?12.7, respectively (p?<?0.01). Daytime voided urine denotes a significant decrease in Group 2 176?±?48, compared with Group 1 221.2?±?79 (p?<?0.01). Daytime frequency and nocturia, were significantly higher in Group 2, compared with Group 1 8.90?±?2.8 versus 7.16?±?3.11, respectively, and 3.1?±?1.2 versus 1.92?±?1.12, respectively (p?<?0.05).

Conclusion: The atherosclerosis disease play a significant role in the impairments of both voiding and storage function in male patients with LUTS irrelevant to the age.     

空穴传输层厚度对OLED性能的影响

该文采用聚乙烯基咔唑(PVK)作为空穴传输层,8-羟基喹啉铝(Alq3)作为发光层,制备了结构为ITO/PVK(0～60nm)/Alq3(60nm)/Mg:Ag/Al的有机发光二极管。通过测试器件的电流-电压-发光亮度特性,研究了空穴传输层厚度对有机发光二极管器件性能的影响,优化了器件功能层的厚度匹配。实验结果表明,有机发光二极管的光电性能与空穴传输层的厚度密切相关,当空穴传输层厚度为15nm时,有机发光二极管器件具有最低的起亮电压、最高的发光亮度和最大的发光效率。     

木罗拉在国产仿罗併上应用的改进

本文通过麻纺工艺实践,就木罗拉在国产仿罗併上应用中出现的问题进行 了技术总结,提出了改进措施,取得了满意的效果.     

波长及金属膜厚度对表面等离子体共振的影响

表面等离子体共振（SPR）传感器的光源波长和金膜的厚度影响表面等离子体共振吸收,波长及金膜厚度不同,共振峰的半宽度及深度就会不同,即仪器的灵敏度和实验现象不同.该文利用MATLAB模拟仿真,计算得出表面等离子体共振传感器不同波段光源对应的最佳金属膜厚度,将中心波长为1 550nm、1 310nm、850nm、660nm 4种光源进行对比,得出光源波长为1 550nm、金膜厚度为40nm时,表面等离子体共振传感器的灵敏度最高,实验现象最明显.