Multiparameter evidence synthesis in epidemiology and medical decision-making: current approaches

Summary.  Alongside the development of meta-analysis as a tool for summarizing research literature, there is renewed interest in broader forms of quantitative synthesis that are aimed at combining evidence from different study designs or evidence on multiple parameters. These have been proposed under various headings: the confidence profile method, cross-design synthesis, hierarchical models and generalized evidence synthesis. Models that are used in health technology assessment are also referred to as representing a synthesis of evidence in a mathematical structure. Here we review alternative approaches to statistical evidence synthesis, and their implications for epidemiology and medical decision-making. The methods include hierarchical models, models informed by evidence on different functions of several parameters and models incorporating both of these features. The need to check for consistency of evidence when using these powerful methods is emphasized. We develop a rationale for evidence synthesis that is based on Bayesian decision modelling and expected value of information theory, which stresses not only the need for a lack of bias in estimates of treatment effects but also a lack of bias in assessments of uncertainty. The increasing reliance of governmental bodies like the UK National Institute for Clinical Excellence on complex evidence synthesis in decision modelling is discussed.     

社会主义精神富裕论

马克思主义经典作家的相关阐述 ,社会主义本质的实现和比较优势的获取 ,精神富裕和物质富裕特殊的关系均表明 ,精神富裕是建设社会主义的应有之义。而精神富裕的导向、认识、实践和凝聚作用 ,又反过来在促进社会主义事业快速、健康与持续发展中扮演着重要角色。同时 ,社会主义精神富裕还具有向度的特性 ,是一个动态开放的发展过程     

浅谈普通高校体育改革的综合化趋势

以教育部2002年颁布的《全国普通高等学校体育课程指导纲要》为基础,结合多年的体育教学经验,对我国普通高校体育改革的综合化发展趋势的相关理论进行了探索与研究,并阐述了体育竟争与创新的综合化、体育目标和功能的综合化、体育技术和手段的综合化、体育场馆管理的综合化等理论。为我国普通高校体育教学与发展提供有益的参考依据。     

刑法溯及力原则立法上的缺失——兼论中间时法的生存之理

<中华人民共和国刑法>对溯及力问题作了从旧兼从轻的原则性规定,这是我国刑法向科学化、民主化方向发展的重要表现,然而刑法在其动态运行中又产生了中间时法的问题.本文通过对中间时法的产生及其机理的分析,并结合中间时法在我国实践中的作用,探讨了刑法对中间时法效力亟待完善的问题.     

Fuzzy K-means clustering models for triangular fuzzy time trajectories

We focus our attention on the classification of fuzzy time trajectories with triangular membership function, described by a given set of individuals. To this purpose, we adopt a fullyinformational approach, explicitly recognizing the informational nature shared by the ingredients of the classification procedure: the observed data (Empirical Information) and the classification model (Theoretical Information). In particular, by supposing that the informational paradigm has a fuzzy nature, we suggest three fuzzy clustering models allowing the classification of the triangular fuzzy time trajectories, based on the analysis of the cross sectional and/or longitudinal characteristics of their components (centers and spreads). Two applicative examples are illustrated.     

N-硝基-N-氨基(取代)甲酰-2,4,6-三氯苯氨类化合物的合成

合成了两种新型兼有植物生长调节剂和除草剂功效的N硝基 -N -氨基 (取代 )甲酰 - 2 ,4 ,6 -三氯苯氨类化合物 ,并经元素分析、红外光谱等证实了它们的结构 .     

论鲁迅的幽默审美观

鲁迅对幽默有着特定的理解 ,本文旨在通过鲁迅关于社会、国民、人性的剖析 ,分析鲁迅的现代幽默审美与《笑林广记》式传统审美的根本区别 ,从而找出作者谐中寓悲、带泪的笑以及讽刺幽默的审美价值     

模糊语言的独特功能

本文对模糊语言的独特功能从日常生活、文学作品、科学医学三方面进行了探讨 ,从而阐明在自然语言中 ,模糊语言是绝对的、普遍的。语言的模糊性缘于客观事物本身的模糊性及人们对客观世界认识的不确定性。     

反Fuzzy子群的直积

1990年R.Biswas在[2]中提出了反Fuzzy子群的概念.在此基础上本文相应定义了反Fuzzy子群的直积.接着讨论了其包括正规、共轭情况下的若干性质.此外,还给出了直积μ_1×μ_2是G×G上的反Fuzzy子群的一个充要条件.     

高压微波催化合成肉桂酸甲酯

在硫酸铁铵的催化下 ,利用高压微波技术 ,快速合成了肉桂酸甲酯。最佳反应条件为 :甲醇和肉桂酸的摩尔比为 5 :1,催化剂用量为 2 .0g ,微波时间为 3min ,微波功率为 72 9W ,产率达93.8%。