A simple estimator for a shared frailty regression model

Summary. We propose a simple estimation procedure for a proportional hazards frailty regression model for clustered survival data in which the dependence is generated by a positive stable distribution. Inferences for the frailty parameter can be obtained by using output from Cox regression analyses. The computational burden is substantially less than that of the other approaches to estimation. The large sample behaviour of the estimator is studied and simulations show that the approximations are appropriate for use with realistic sample sizes. The methods are motivated by studies of familial associations in the natural history of diseases. Their practical utility is illustrated with sib pair data from Beaver Dam, Wisconsin.     

延迟支付条件下易逝品的最优订货决策研究

本文在考虑延期支付的情况下构建了二级供应链关于易逝品的最优订货决策模型,其中供应链由单个供应商和多个面临资金约束的零售商组成。在不允许缺货的情况下,供应商为零售商提供延迟支付来缓解零售商的资金压力,同时零售商对产品的定价将随易逝品的价值变质而变化。本文利用遗传算法对模型进行了算例分析,同时对模型中的相关参数进行了敏感性分析。结果表明,延迟支付能够提高供应链总利润并降低风险,从而有利于供应链整体效益的提高。在延期支付条件下,供应链各成员获得的收益增量存在较大差距,其中供应商能够获得更多收益。最后,通过敏感性分析,我们还发现产量及易逝品保质期的变动会对供应链整体利润产生不同程度的影响。     

Penalty guided genetic search for redundancy optimization in multi-state series-parallel power system

This paper presents a genetic algorithm (GA) for parallel redundancy optimization in series-parallel power systems exhibiting multi-state behavior, optimizing the reliability subject to constraints. The components are binary and chosen from a list of products available in the market, and are being characterized by their feeding capacity, reliability, cost and weight. System reliability is defined as the ability to satisfy consumer demand and is presented as a piecewise cumulative load curve. In GA, to handle infeasible solutions penalty strategies are used. Penalty technique keep a certain amount of infeasible solutions in each generation so as to enforce genetic search towards an optimal solution from sides of, both, feasible and infeasible regions. We here present a dynamic adaptive penalty function which helps the algorithm to search efficiently for optimal/near optimal solution. To evaluate system reliability, a fast procedure, based on universal generating function, is used. An example considering a multi-state series-parallel power system is solved considering both homogeneous and heterogeneous types of redundancy. Also an example considering price discounts is solved. The effectiveness of the penalty function and the proposed algorithm is studied and shown graphically.     

基于自组织算法的改进型GAANN预测模型

在传统的基于GA算法人工神经网络的基础上作了改进,将训练集分为两部分,在前一训练集训练后获得的网络基础上使用后一训练集进行进一步的训练获得更为优化的网络结构。针对复杂系统建模输入节点难以确定的问题,提出将其与自组织理论相结合,首先使用GMDH方法获得神经网络的初始化节点,然后使用训练好的神经网络模型进行预测。最后,将由此建立的预测模型应用于国家粮食产量预测,取得了令人满意的效果。     

基于卓越绩效模式的供应链质量成本优化研究

本文以供应链质量成本为主要研究对象,分析归纳供应链质量成本研究现状,结合卓越绩效模式方法,提出质量成本核算体系,建立基于卓越绩效模式的供应链质量成本模型。通过一个应用案例,采用遗传算法求解,证明该方法使供应链成本得到了优化。     

高维大数据基因网络中的社区发现——以NC方法为例

从大量基因中识别出致病基因是大数据下的一个十分重要的高维统计问题。基因间网络结构的存在使得对于致病基因的识别已从单个基因识别扩展到基因模块识别。从基因网络中挖掘出基因模块就是所谓的社区发现（或节点聚类）问题。绝大多数社区发现方法仅利用网络结构信息,而忽略节点本身的信息。Newman和Clauset于2016年提出了一个将二者有机结合的基于统计推断的社区发现方法（简称为NC方法）。本文以NC方法为案例,介绍统计方法在实际基因网络中的应用和取得的成果,并从统计学角度提出了改进措施。通过对NC方法的分析可以看出对于以基因网络为代表的非结构化数据,统计思想和原理在数据分析中仍然处于核心地位。而相应的统计方法则需要针对数据的特点及关心的问题进行相应的调整和优化。     

An upper bound on the minimal total cost of the transportation problem with varying demands and supplies

In general cases, to find the exact upper bound on the minimal total cost of the transportation problem with varying demands and supplies is an NP-hard problem. In literature, there are only two approaches with several shortcomings to solve the problem. In this paper, the problem is formulated as a bi-level programming model, and proven to be solvable in a polynomial time if the sum of the lower bounds for all the supplies is no less than the sum of the upper bounds for all the demands; and a heuristic algorithm named TPVDS-A based on genetic algorithm is developed as an efficient and robust solution method of the model. Computational experiments on benchmark and new randomly generated instances show that the TPVDS-A algorithm outperforms the two existing approaches.     

文化与基因有无联系?——现代达尔文主义进军社会领域的思想轨迹

文化与基因是否有关系?达尔文的进化论与社会人文科学的关系如何?解决这些问题,就需要从达尔文主义入手,进而研究达尔文主义与"社会达尔文主义"和种族主义的根本差别,显然,达尔文主义进入人性和道德等领域过程中出现的动物行为学、社会生物学和进化心理学等学科,扩展了人们关于人自身的认识,对人文社会科学的发展具有推动作用。但也留下一系列不能简单地用基因与文化的直接关系来解决的难题。为了解决这些问题,需要对人类的行为模式和心理机制作深入科学的、历史的研究。     

Quadratic estimation in mixed linear models with two variance components

Explicit expressions for Bayes invariant quadratic estimates, biased and unbiased, are presented and proved to cover the entire class of admissible estimates in the considered classes. An unbalanced genetic model is studied for demonstration.     

Genetic and environmental influences on cognition during childhood

The basic methodology of behavior genetics is described in the context of the twin and sibling/adoption design. Results of applying this model to cross-sectional data on cognitive development throughout the lifespan are presented. Results from a large longitudinal twin and adoption study of general intelligence are presented to illustrate the use of the basic behavior genetic model in studying the causes of continuity and change in development. A special model is presented for the study of abnormal behavior occurring at the extremes of the distribution and an adaptation of the model is discussed for the study of genetic linkage or the mapping of quantitative trait loci (QTL). Results of applying this model to a sample of twins and kindred siblings indicated the presence of a major QTL for dyslexia on chromosome 6. The purpose of the paper is to illustrate the scope of behavior genetic methodology in studying individual differences in behavior in a biosocial context.