Causal inference with generalized structural mean models

Summary.  We estimate cause–effect relationships in empirical research where exposures are not completely controlled, as in observational studies or with patient non-compliance and self-selected treatment switches in randomized clinical trials. Additive and multiplicative structural mean models have proved useful for this but suffer from the classical limitations of linear and log-linear models when accommodating binary data. We propose the generalized structural mean model to overcome these limitations. This is a semiparametric two-stage model which extends the structural mean model to handle non-linear average exposure effects. The first-stage structural model describes the causal effect of received exposure by contrasting the means of observed and potential exposure-free outcomes in exposed subsets of the population. For identification of the structural parameters, a second stage 'nuisance' model is introduced. This takes the form of a classical association model for expected outcomes given observed exposure. Under the model, we derive estimating equations which yield consistent, asymptotically normal and efficient estimators of the structural effects. We examine their robustness to model misspecification and construct robust estimators in the absence of any exposure effect. The double-logistic structural mean model is developed in more detail to estimate the effect of observed exposure on the success of treatment in a randomized controlled blood pressure reduction trial with self-selected non-compliance.     

Testing symmetry under a skew Laplace model

We develop tests of hypothesis about symmetry based on samples from possibly asymmetric Laplace distributions and present exact and limiting distribution of the test statistics. We postulate that the test statistic derived under the Laplace model is a rational choice as a measure of skewness and can be used in testing symmetry for other, quite general classes of skew distributions. Our results are applied to foreign exchange rates for 15 currencies.     

On Rao score and PearsonX 2 statistics in generalized linear models

The identity of the Rao score and PearsonX ² statistics is well known in the areas where the latter was first introduced: goodness-of-fit in contingency tables and binary responses. We show in this paper that the same identity holds when the two statistics are used for testing goodness-of-fit of Generalized Linear Models. We also highlight the connections that exist between the two statistics when they are used for the comparison of nested models. Finally, we discuss some merits of these unifying results. Work financially supported by cofin. MIUR grants 2000 and 2002.     

硕士研究生入学英语考试英译汉试题的特点及翻译技巧

深入分析历年硕士研究生入学英语考试英译汉试题的特点,总结四方面特点,提出具有针对性的翻译方法和技巧作为对策:(1)试题中的词汇难以见词明义,需根据上下文选择确定词义或对词义进行引申;(2)句子的理解与翻译对上下文的依赖性很强,需使用还原法对原文中的替代、省略、变换等表达进行还原翻译;(3)句子较长,结构复杂,需采用分译法;(4)很多句子的表意方式和语序体现出英美人的思维习惯和特点,需作语序调整。     

中国产业结构变动与就业水平的实证研究

文章运用时间序列和计量模型研究了中国产业结构与就业水平之间的发展关系.首先运用格兰杰因果检验分析了第一、二、三次产业的产值与其就业之间的因果影响关系,继而从产值与就业两个角度定量分析了第一、二、三次产业各自对总就业水平的贡献,得出结论:第一产业和第三产业是劳动力就业的决定因素,而第二产业不是就业的决定因素;从产值角度来看,第三产业对劳动力就业的贡献最大,从就业角度来看,第一产业的就业对总体就业水平的贡献最高,其次是第三产业,而第二产业的就业对总体就业水平的贡献最小.最后根据研究结论提出相应的建议措施.     

我国房地产市场财富效应的实证分析

本文应用格兰杰因果关系检验和协整分析方法,对我国房地产市场的财富效应作了实证分析。实证结果表明,我国房地产市场不具有财富效应而仅具有替代效应。     

Detecting parameter shift in garch models

This paper applies recent theories of testing for parameter constancy to the conditional variance in a GARCH model. The supremum Lagrange multiplier test for conditional Gaussian GARCH models and its robustified variants are discussed. The asymptotic null distribution of the test statistics are derived from the weak convergence of the scores, and the critical values from the hitting probability of squared Bessel process.

Monte Carlo studies on the finite sample size and power performance of the supremum LM tests are conducted. Applications of these tests to S&P 500 indicate that the hypothesis of stable conditional variance parameters can be rejected.     

Testing the Equality of Two Exponential Distributions

This paper proposes an overlapping-based test statistic for testing the equality of two exponential distributions with different scale and location parameters. The test statistic is defined as the maximum likelihood estimate of the Weitzman's overlapping coefficient, which estimates the agreement of two densities. The proposed test statistic is derived in closed form. Simulated critical points are generated for the proposed test statistic for various sample sizes and significance levels via Monte Carlo Simulations. Statistical powers of the proposed test are computed via simulation studies and compared to those of the existing Log likelihood ratio test.     

Point Estimates of Test Sensitivity and Specificity from Sample Means and Variances

In a wide variety of biomedical and clinical research studies, sample statistics from diagnostic marker measurements are presented as a means of distinguishing between two populations, such as with and without disease. Intuitively, a larger difference between the mean values of a marker for the two populations, and a smaller spread of values within each population, should lead to more reliable classification rules based on this marker. We formalize this intuitive notion by deriving practical, new, closed-form expressions for the sensitivity and specificity of three different discriminant tests defined in terms of the sample means and standard deviations of diagnostic marker measurements. The three discriminant tests evaluated are based, respectively, on the Euclidean distance and the Mahalanobis distance between means, and a likelihood ratio analysis. Expressions for the effects of measurement error are also presented. Our final expressions assume that the diagnostic markers follow independent normal distributions for the two populations, although it will be clear that other known distributions may be similarly analyzed. We then discuss applications drawn from the medical literature, although the formalism is clearly not restricted to that application.     

A Comparative Study of Model-based Tests of Independence for Ordinal Data Using the Bootstrap

When analyzing categorical data using loglinear models in sparse contingency tables, asymptotic results may fail. In this paper the empirical properties of three commonly used asymptotic tests of independence, based on the uniform association model for ordinal data, are investigated by means of Monte Carlo simulation. Five different bootstrapped tests of independence are presented and compared to the asymptotic tests. The comparisons are made with respect to both size and power properties of the tests. Results indicate that the asymptotic tests have poor size control. The test based on the estimated association parameter is severely conservative and the two chi-squared tests (Pearson, likelihood-ratio) are both liberal. The bootstrap tests that either use a parametric assumption or are based on non-pivotal test statistics do not perform better than the asymptotic tests in all situations. The bootstrap tests that are based on approximately pivotal statistics provide both adjustment of size and enhancement of power. These tests are therefore recommended for use in situations similar to those included in the simulation study.