基于互信息的功能磁共振图像配准

互信息作为衡量两幅图像配准的相似性测度函数,当两幅图像配准时,互信息达到最大值。该文提出了基于互信息脑功能磁共振图像配准新方法,采用了无需计算梯度的Powell直接搜索算法,并通过多分辨的方式加快了图像配准速度。磁共振的配准实验证明,互信息法能准确地实现多模态医学图像的配准,并且能达到亚像素的精度。     

Identifying Skeleton Curves in Noisy Data

This article presents a Bayesian method to reconstruct the centerline in noisy data using B-spline curves. The method is illustrated on simulated two- and three-dimensional data and is applied to recover the centerline of the colon in single photon emission computed tomography images.     

Sex differences in the development of mild cognitive impairment and probable Alzheimer’s disease as predicted by hippocampal volume or white matter hyperintensities

This study examined biological sex differences in the development of mild cognitive impairment (MCI) and probable Alzheimer’s disease (AD) development as predicted by changes in the hippocampus or white matter hyperintensities. A secondary data analysis of the National Alzheimer’s Coordinating Center Uniform Data Set was conducted. We selected samples of participants with normal cognition at baseline who progressed to MCI (n = 483) and those who progressed to probable AD (n = 211) to determine if hippocampal volume or white matter hyperintensities (WMH) at baseline predicted progression to probable AD or MCI and whether the rate of progression differed between men and women. The survival analyses indicated that changes in hippocampal volumes affected the progression to probable AD (HR = 0.535, 95% CI [0.300–0.953]) only among women. White men had an increased rate of progression to AD (HR = 4.396, CI [1.012–19.08]; HR = 4.665, 95% CI [1.072–20.29]) compared to men in other race and ethnic groups. Among women, increases in hippocampal volume ratio led to decreased rates of progressing to MCI (HR = 0.386, 95% CI [0.166–0.901]). Increased WMH among men led to faster progression to MCI (HR = 1.048. 95% CI [1.011–1.086]). Women and men who were older at baseline were more likely to progress to MCI. In addition, results from longitudinal analyses showed that women with a higher CDR global score, older age at baseline, or more disinhibition symptoms experienced higher odds of MCI development. Changes in hippocampal volumes affect the progression to or odds of probable AD (and MCI) more so among women than men, while changes in WMH affected the progression to MCI only among men.     

Medicare and Amyloid PET Imaging: The Battle Over Evidence

We examine a recent dispute regarding the Centers for Medicare and Medicaid Services’ (CMS) refusal to unconditionally pay for amyloid positron emission tomography (PET) imaging for Medicare beneficiaries being assessed for Alzheimer’s disease. CMS will only pay for amyloid PET imaging when patients are enrolled in clinical trials that meet certain criteria. The dispute reflects CMS’s willingness in certain circumstances to require effectiveness evidence that differs from the Food and Drug Administration’s standard for pre-market approval of a medical intervention and reveals how stakeholders with differing perspectives about evidentiary standards have played a role in attempting to shape the Medicare program’s coverage policies.     

数字多声束形成技术

医用超声诊断设备中存在两种声束形成技术。近年来在少数几个高档设备中使用了数字声束形成技术。正交分解是获得复包络信号的幅度和相位的关键，而数字延迟是数字电子聚焦所必须的。文中介绍了数字多声束形成的原理及应用。     

A Spatio-Temporal Model for Functional Magnetic Resonance Imaging Data – with a View to Resting State Networks

Abstract.  Functional magnetic resonance imaging (fMRI) is a technique for studying the active human brain. During the fMRI experiment, a sequence of MR images is obtained, where the brain is represented as a set of voxels. The data obtained are a realization of a complex spatio-temporal process with many sources of variation, both biological and technical. We present a spatio-temporal point process model approach for fMRI data where the temporal and spatial activation are modelled simultaneously. It is possible to analyse other characteristics of the data than just the locations of active brain regions, such as the interaction between the active regions. We discuss both classical statistical inference and Bayesian inference in the model. We analyse simulated data without repeated stimuli both for location of the activated regions and for interactions between the activated regions. An example of analysis of fMRI data, using this approach, is presented.     

Estimation of relaxation time distributions in magnetic resonance imaging

Magnetic resonance imaging techniques can be used to measure some biophysical properties of tissue. In this context, the T₂ relaxation time is an important parameter for soft‐tissue contrast. The authors develop a new technique to estimate the integral of the distribution of T₂ relaxation time without imposing any constraint other than the monotonicity of the underlying cumulative relaxation time distribution. They explore the properties of the estimation and its applications for the analysis of breast tissue data. As they show, an extension of linear discriminant analysis is found to distinguish well between two classes of breast tissue.     

SAR的海洋遥感探测技术综述

从研究SAR的海洋遥感探测重要性和基本特点出发,概述了SAR系统的海洋遥感探测技术所涉及的主要研究内容,针对海洋环境要素分布的随机性和时变性,研究了海面微波散射特性和SAR的海面成像机理,给出了研究结果;分析了SAR系统主要特点,提出研究包括系统的宽测绘带特性和雷达的弱信号获取、海面精确成像算法和时空相关性等方面;同时探讨了海洋目标检测的技术途径,以满足SAR系统海洋观测应用的需要.     

Adaptive weights smoothing with applications to image restoration

We propose a new method of nonparametric estimation which is based on locally constant smoothing with an adaptive choice of weights for every pair of data points. Some theoretical properties of the procedure are investigated. Then we demonstrate the performance of the method on some simulated univariate and bivariate examples and compare it with other nonparametric methods. Finally we discuss applications of this procedure to magnetic resonance and satellite imaging.     

慢性腰背痛影像学分析

目的分析慢性腰背痛患者,通过影像学检查对某些患者作出定性诊断.方法所有病例均拍腰椎正侧、双斜位片.疑椎间盘病变者作CT或/和Mm检查.结果腰椎退行性骨关节病76例,腰椎间盘突出症16例,椎弓峡部崩裂和脊柱滑脱23例,先天变异38例.结论通过影像学检查可以对慢性腰背痛患者的病因作出诊断.