Statistics for weighing benefits and harms in a proposed genetic substudy of a randomized cancer prevention trial

Summary.  When evaluating potential interventions for cancer prevention, it is necessary to compare benefits and harms. With new study designs, new statistical approaches may be needed to facilitate this comparison. A case in point arose in a proposed genetic substudy of a randomized trial of tamoxifen versus placebo in asymptomatic women who were at high risk for breast cancer. Although the randomized trial showed that tamoxifen substantially reduced the risk of breast cancer, the harms from tamoxifen were serious and some were life threaten-ing. In hopes of finding a subset of women with inherited risk genes who derive greater bene-fits from tamoxifen, we proposed a nested case–control study to test some trial subjects for various genes and new statistical methods to extrapolate benefits and harms to the general population. An important design question is whether or not the study should target common low penetrance genes. Our calculations show that useful results are only likely with rare high penetrance genes.     

汉语格语法研究述评

自上世纪70年代起,格语法理论便在汉语语法研究中得以运用。该文简要回顾了海外华人语言学者、中国大陆汉语学者以及计算机学者关于汉语格的研究成果,并指出格语法理论对于语义的关注,正好契合了汉语缺乏形态变化而讲究意合的特点,因此我们应该将“格”作为现代汉语语法研究的一项重要课题来研究。     

MBA教育的对比分析及建议

本文着重在课程设计 ,教学特点 ,以及硬件环境上就加拿大毅伟管理学院和电子科技大学的MBA教育进行了对比分析 ,并对我校的MBA教育提出了几点建议     

从英汉非宾格动词的比较谈汉译英中动词的翻译

传统语法将动词分为及物动词和不及物动词,已不足以反映动词的特性。从生成语法的角度对英汉非宾格动词进行比较之后,将有利于学习和掌握英汉互译。     

A strategy for third-party logistics systems: A case analysis using the blue ocean strategy

One of today's most frequently discussed topics in the business world is how to escape from the intense Red Ocean and how to create an uncontested Blue Ocean. However, because there are few practical guidelines available on this topic, we will introduce a case study of a third-party logistics (3PL) provider, CJ-Global Logistics Service (CJ-GLS), to show how it aspires to be a leader in the newly introduced 3PL industry in South Korea. CJ-GLS is a latecomer in the logistics industry, and its resources, such as the number of trucks and warehouses, are relatively small in comparison to those of established companies. But, it has achieved a distinct competitive advantage through innovative information technology (i.e., RFID—radio frequency identification), which has enabled it to create an uncontested market space, electronic logistics business. One remarkable fact about CJ-GLS is that its swift growth comes not from attracting competitors’ customers from the existing Red Ocean market but from creating a Blue Ocean market (3PL market), which previously existing incumbents ignored, and also from constructing a new business model founded on a RFID-based, ubiquitous-oriented 3PL system. Analyzed through a Four Actions Framework and characterized as Blue Ocean, this case study provides valuable information on how a company reinforces its competitive advantage from the Red Ocean while it transitions into a Blue Ocean by utilizing advanced information communication technologies.     

Influence Diagnostics on Testing Linear Hypothesis in Linear Models with Correlated Errors

To assess the influence of observations on the parameter estimates, case deletion diagnostics are commonly used in linear regression models. For linear models with correlated errors we study the influence of observations on testing a linear hypothesis using single and multiple case deletions. The change in likelihood ratio test and F test theoretically is derived and it is shown these tests to be completely determined by two proposed generalized externally studentized residuals. An illustrative example of a real data set is also reported.     

The Representation of the Family’s Voice in Serious Case Review Reports of Child Maltreatment

Australia and the United Kingdom have mandatory systems of case reviews, which are conducted whenever a child known to welfare or health services has died or been seriously harmed due to maltreatment. In the United Kingdom those conducting case reviews are required to involve family members in their deliberations. This study employed discourse analysis to examine the representation of family voices in 41 Overview Reports of Serious Case Reviews undertaken in England and published during 2014. The findings revealed that the contributions of family members were generally relegated or their legitimacy undercut by the positivist framing of most overview reports. However, the research also identified how the framing of family contributions within an interpretivist paradigm could engender highly complex understanding of deficiencies in child protection systems and lead to crucial new learning for professionals.     

Combinations of absorptive capacity metaroutines: The role of organizational disruptions and time constraints

This paper explores absorptive capacity metaroutines in a financial organization that experienced a large-scale misappropriation episode. We selected an instrumental case and collected individual semi-structured interviews, on-site nonparticipant observations, and documents to better understand the combination of absorptive capacity in organizational contexts. Findings revealed that the magnitude of organizational disruptions and time constraints influenced absorptive capacity metaroutines. The magnitude of organizational disruptions related to the intensity of required change for innovation adoption and the persistence of outcomes, while time constraints influenced the degree of involvement and cohesiveness of organizational members. In addition, findings showed that the combination of absorptive capacity metaroutines experienced asymmetries and had incremental and cumulative features. This work extends current theorizations of absorptive capacity conceptualized from a micro-foundation perspective as a collection of external and internal metaroutines and provides a means to start understanding potential factors that influence the combination of absorptive capacity metaroutines. Implications for theory and practice are discussed, and suggestions for future research are offered.     

问题式学习对社会工作专业课程教学改革的启示——以个案工作课程为例

问题式学习教学模式以建构主义为基础,认为学生是知识意义的主动建构者,教师只是意义建构的帮助者和促进者。这一基本理念与社会工作"助人自助"核心理念,以及社会工作强调案主与工作者平等专业关系的要求具有诸多共通之处。通过对问题式个案工作课程的教学设计,学生不仅收获了专业理论与专业知识,更是通过问题式学习过程深化了专家价值观的认同,以及对社会工作实务开展具体过程的理解。