左旋咪唑对免疫抑制小鼠血中尿素、肌酐和活性氧的影响

以小白鼠为实验动物 ,观察左旋咪唑对免疫抑制小鼠血中尿素、肌酐和活性氧的影响。结果表明 :实验组小白鼠血液中尿素含量显著低于对照组 (P <0 .0 5 ) ,肌酐含量无明显变化 (P >0 .0 5 )。而血清活性氧的含量显著低于对照组 (P <0 .0 5 )。     

“欲”的剥示——论《但泽三部曲·猫与鼠》中赋启蒙精神的象征意象

君特.格拉斯是一位著名的战后德国文学家,他以其主要作品《但泽三部曲》(《铁皮鼓》、《猫与鼠》、《狗年月》)获得了1999年诺贝尔文学奖。而《猫与鼠》,作为三部曲中唯一的中篇却以其前所未有张力和丰富博深的象征意象承载并传达着作者宏大的启蒙精神。以此为解码口,详细论述《猫与鼠》中赋启蒙精神的象征意象,以此探寻作者最深邃、最睿智的思想深处,开掘德意志民族的精神本源。     

Practical statistical considerations for investigating anti-tumor treatments in mice

Anti-tumor treatment outcomes in mouse experiments can be challenging to interpret and communicate accurately. In reporting these experiments, rigorous statistical considerations are commonly absent, although statistical applications have been proposed. We investigated the practicality and utility of different statistical strategies for the analysis of anti-tumor responses in a longitudinal mouse case study. Each analysis that we performed had different endpoints, investigated different questions, and was based on different assumptions. We found rudimentary visual and risk analysis insufficient without additional considerations, and upon further investigation we found improvements in key anti-tumor parameter estimates associated with a drug combination in our case study. We offer practical statistical considerations for investigating anti-cancer treatments in mice, applying a multi-tier statistical approach.     

产后康复宁的致突变、致畸试验研究

为了中药产后康复宁的临床应用 ,保证用药安全 ,本试验采用小白鼠骨髓多染红细胞微核试验和小白鼠致畸试验等方法 ,对产后康复宁的致突变性和致畸性进行了观察。小白鼠骨髓多染红细胞微核实验结果PCE/NCE为 1.0 0 85 /l.2 5 6 7。结论产后康复宁无突变作用。     

A nonlinear regression model for describing averaged growth curves of mice

A general four parameter growth curve is presented as a model for the growth curve of a group of mice for which averaged weights of the group are available. Several data sets of mice weights obtained from experiments performed at the National Center for Toxicological Research are analyzed. The results are compared with traditional models for growth curves. Both additive and multiplicative error models are analyzed. It is shown that for this data the four parameter model gives a much better fit than traditional growth curve models and should be given serious consideration in model fitting.     

黄芪多糖对获得性免疫抑制小鼠血液中NO、GPT及CHOL的影响

本文采用皮下注射地塞米松 0 .5mg/d ,连用 3d的方法制备了获得性免疫抑制小鼠 ,研究了黄芪多糖 1.0、2 .0、4 .0mg/d连续灌胃 5d,于停药后 2 4h和 96h时免疫抑制小鼠血液中NO、谷丙转氨酶 (GPT)及胆固醇 (CHOL)的变化。结果为黄芪多糖能降低小鼠血液中NO和GPT含量 ,同时使CHOL有所升高。表明黄芪多糖具有清除血液自由基、改善肝脏机能及调节免疫等作用