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目的介绍近年来血管生成抑制剂的研究进展。方法查阅相关文献进行总结、归纳。结果血管生成抑制剂的研究取得很大进展。结论对寻找高效、低毒副作用的血管生成抑制剂具有重要意义。 相似文献
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Jaimatha Arivazhagan Lalgudi Narayanan Dorairajan Karli Sreenivasulu 《The aging male》2017,20(2):115-118
Introduction: Inflammation and angiogenesis are known to play a role in the development prostate tumors. The present study was designed to assess the levels of markers of inflammation and angiogenesis like interleukin-17 (IL-17) and angiopoietin-2 (ANGPT2) levels and their association with prostate size in patients with benign prostatic hyperplasia (BPH).Materials and methods: 42 BPH cases and 42 controls were enrolled in the study. IL-17 and ANGPT2 were estimated in both the groups.Results: IL-17 and ANGPT2 were significantly increased in BPH cases when compared with controls. Multivariate analysis showed that ANGPT2 predicts the prostate size in patients with BPH (R2?=?0.203, beta?=?0.355, p?=?0.028). Linear regression analysis showed that IL-17 was significantly associated with ANGPT2 in BPH cases (R2?=?0.129, beta – 0.359, p?=?0.020).Conclusions: We conclude that IL-17 and ANGPT2 are elevated in BPH cases and ANGPT2 was associated with IL-17 and prostate size. 相似文献
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