信息技术在图书馆采编工作中的应用

信息技术的应用和普及对图书工作产生了革命性的影响，章对信息技术快速存储信息，快速处理信息，远距离传送信息等功能进行了分析，探讨了当前网络环境下信息技术在图书馆采编工作中的意义和作用。     

图式理论、学习策略与大学英语口语教学

本研究采用定量分析的方法,对84名天水师范学院非英语专业的学生的口语水平进行测试。根据图式理论,口语任务分为有关键词及句型提示类和无提示类,并对被试的学习策略使用情况做了调查,结果发现,口语任务有提示与无提示对学生的口语成绩有显著影响,这说明图式理论完全适用于大学英语口语教学。     

二维变系数线性微分系统的求解定理

给出二维变系数线性微分系统在已知某解的情形下求通解的公式,并直接应用此公式,导出几类二维变系数线性微分系统的通解公式.对理论和实际应用都是有益的.     

Sequential Hypothesis Tests for Identifying the Minimum Dose with a Threshold Effect

We propose a procedure to identify a lowest dose having greater effect than a threshold dose under the assumption of monotonicity of dose mean response in dose response test. So, we use statistics based on contrasts among sample means and apply a group sequential procedure to our procedure to identify effectively the dose. If we can identify the dose at an early step in the sequential test, since we can terminate the procedure with a few observations, the procedure is useful from an economical point of view. In a simulation studies, we compare the superiority among these procedures based on three contrasts.     

古代突厥文碑铭的发现和解读--纪念汤木森解读古代突厥文一百一十年

文章概述了突厥汗国的发展变化历程和古代突厥文碑铭的发现及研究情况 ,以纪念丹麦科学家魏·汤木森成功解读古代突厥文 1 1 0年 ,并反思了中国在此领域的研究状况。     

大学生择业心理、择业观念的调查与分析

当代大学生择业的时代意识明显 ,定位基本标准 ,而择业期望偏高、社会责任感淡薄、专业意识淡化。因此 ,必须加强对大学生的思想政治教育 ,加强对大学生的就业指导 ,努力建设大学生就业的全国网络市场     

Identifying the most successful dose (MSD) in dose-finding studies in cancer

For a dose finding study in cancer, the most successful dose (MSD), among a group of available doses, is that dose at which the overall success rate is the highest. This rate is the product of the rate of seeing non-toxicities together with the rate of tumor response. A successful dose finding trial in this context is one where we manage to identify the MSD in an efficient manner. In practice we may also need to consider algorithms for identifying the MSD which can incorporate certain restrictions, the most common restriction maintaining the estimated toxicity rate alone below some maximum rate. In this case the MSD may correspond to a different level than that for the unconstrained MSD and, in providing a final recommendation, it is important to underline that it is subject to the given constraint. We work with the approach described in O'Quigley et al. [Biometrics 2001; 57(4):1018-1029]. The focus of that work was dose finding in HIV where both information on toxicity and efficacy were almost immediately available. Recent cancer studies are beginning to fall under this same heading where, as before, toxicity can be quickly evaluated and, in addition, we can rely on biological markers or other measures of tumor response. Mindful of the particular context of cancer, our purpose here is to consider the methodology developed by O'Quigley et al. and its practical implementation. We also carry out a study on the doubly under-parameterized model, developed by O'Quigley et al. but not     

A simulation study of methods for selecting subgroup‐specific doses in phase 1 trials

Patient heterogeneity may complicate dose‐finding in phase 1 clinical trials if the dose‐toxicity curves differ between subgroups. Conducting separate trials within subgroups may lead to infeasibly small sample sizes in subgroups having low prevalence. Alternatively,it is not obvious how to conduct a single trial while accounting for heterogeneity. To address this problem,we consider a generalization of the continual reassessment method on the basis of a hierarchical Bayesian dose‐toxicity model that borrows strength between subgroups under the assumption that the subgroups are exchangeable. We evaluate a design using this model that includes subgroup‐specific dose selection and safety rules. A simulation study is presented that includes comparison of this method to 3 alternative approaches,on the basis of nonhierarchical models,that make different types of assumptions about within‐subgroup dose‐toxicity curves. The simulations show that the hierarchical model‐based method is recommended in settings where the dose‐toxicity curves are exchangeable between subgroups. We present practical guidelines for application and provide computer programs for trial simulation and conduct.     

Sustainable business – Leading yourself and business into the future

Abstract

In the industrial era the development and use of the term ‘economic efficiency’ was too narrow. The exclusive one-sided focus on financial success led to consequences with yet unforeseeable risks and dangers. We must radically redefine economic efficiency if we want to foster well-known and needed sustainable living conditions on earth. To act in an economical fashion must imply value creation for the company, the environment and society. The evaluation of economic success must take all three criteria of value into account equally. To achieve such sustainable win-win-win situations, the full utilization of employee and business partner potential is required. Only an evolving culture of cooperation at all levels will ensure best solutions for developing and maintaining a healthy life base, leading away from the paradigm of absolute competition. Ways and means to reach these objectives are presented: old wisdom is combined with modern management control systems and the consequent change in evaluating the success of management.     

结核菌素试验在入学新生结核病例搜寻中的应用

青年阶段是结核病发病的高峰年令组。本文通过对苏州铁道师院1982～1991年十届新生2983人所作的结核茵素试验结果的分析论证证明:及早发现及控制传染源,切断传染途经,保护易感人群是学校防痨的根本。对入学新生进行结素试验,阴性者接种卡介苗,强阳性者进行肺部过筛检查,并予以异烟肼化疗预防,应列为大学生结核病防治常规。