351例高龄老人高尿酸血症相关因素分析

目的探讨高龄老人血尿酸的变化及与血压、血脂的关系。方法选择351例2004年6月至2008年6月在我院住院的70岁以上高龄老年人为研究对象,以血尿酸≥416mmol／L为界限,大于该值为高尿酸血症,血胆固醇≥5．72mmol／L为高胆固醇血症,血甘油三酯≥1．71mmol/L为高甘油三酯血症。结果高尿酸血症者120例,占34．1％,（70—79）岁、（80—89）岁、〉190岁高尿酸血症者分别为28．7％、43．1％、66．7％（P〈0．05）,且随年龄增长血尿酸也呈增加趋势（P〈0．01）,高尿酸血症组的收缩压、甘油三酯明显高于尿酸正常组（均为P〈0．05）。结论老年人高尿酸血症发生率高,且随年龄增加高尿酸血症的患病率和血尿酸的值均增加,高龄老人高尿酸血症与血压、血脂明显相关。     

抗氧化修饰低密度脂蛋白单克隆抗体的制备及其初步应用

用氧化修饰脂蛋白（ａ）对Ｂａｌｂ／ｃ小鼠免疫．利用淋巴细胞杂交瘤技术制备了鼠抗人氧化修饰低密度脂蛋白（ｏｘｉｄａｔｉｖｅｌｙｍｏｄｉｆｉｅｄｌｏｗｄｅｎｓｉｔｙｌｉｐｏｐｒｏｔｅｉｎ，ｏｘＬＤＬ）单克隆抗体细胞株．以单克隆抗体包被建立了酶联免疫吸附（ＥＬＩＳＡ）双抗夹心法．用此法对１０例冠心病患者、６例其他心脏病患者、１０例正常健康人血浆中ｏｘＬＤＬ的含量进行了测定．结果表明，冠心病患者血浆中ｏｘＬＤＬ水平明显高于其他心脏病组和正常对照组．本实验所建立的方法对诊断冠心病患者血浆中的ｏｘＬＤＬ具有重要意义     

The Patient Profile Pharmacy Filing System

Abstract

“Herpes Simplex Virus Proctitis in Homosexual Men: Clinical, Sigmoidoscopic, and Histopathological Features,” Steven E. Goodell, Thomas C. Quinn, Emmanuel Mkrtichian, Michael D. Schuffler, King K. Holmes, and Lawrence Corey. Acute herpes simplex virus (HSV) infection was detected in 23 of 102 consecutively examined, sexually active male homosexuals who presented with anorectal pain, discharge, tenesmus, or hematochezia, as compared with 3 of 75 homosexual men without gastrointestinal symptoms (P < 0.01). Findings that were significantly more frequent in men with HSV proctitis than in men with proctitis due to other infectious causes included fever (48 per cent), difficulty urinating (48 per cent), sacral paresthesias (26 per cent), inguinal lymphadenopathy (57 per cent), severe anorectal pain (100 per cent), tenesmus (100 per cent), constipation (78 per cent), perianal ulcerations (70 per cent), and the presence of diffuse ulcerative or discrete vesicular or pustular lesions in the distal 5 cm of the rectum (50 per cent). Serologic evidence indicated that 85 per cent of the men with symptomatic HSV proctitis were having their first episode of HSV-2 infection. The diagnosis of HSV proctitis is suggested by the presence of severe anorectal pain, and diffuse ulceration of the distal rectal mucosa. (New England Journal of Medicine 1983;308:868–71.)     

The Status of Nutrition Education in ACHA College and University Health Centers

Abstract

An assessment of the prevalence and scope of nutrition services offered through 208 randomly selected American College Health Association member student health centers revealed that 79% of the 160 respondents provided some type of nutrition education for students. One-to-one counseling, available at 96% of the institutions, was the most common approach. The larger the school's enrollment, the more likely it was to provide programs in nutrition. All of the institutions with student populations of more than 35,000 offered some type of nutrition service, as did 52% of the 19 schools with enrollments between 2,000 and 5,000. Health educators, nurses, doctors, dietitians, and trained peer educators provided the services, with registered dietitians the most common providers and often coordinators of the programs. Costs to students for nutrition interventions were nominal; weightmanagement programs were the most expensive and showed the greatest variation in content.     

Research of stroke combined hyperlipidemia-induced erectile dysfunction in rat model

Abstract

Objective: The study was aimed to evaluate the influences of erectile dysfunction (ED) in a rat model of stroke combined with hyperlipidemia (HLP).

Methods: Male Sprague–Dawley rats were divided into control and hyperlipidemia (HLP) groups. HLP model was constructed by feeding with high-fat and cholesterol diets. Serum levels of total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG), and non-HDL were identified to check the model was success. Stroke model was established by FeCl₃. ICP/MAP value was detected to evaluate the erectile function of rats. Serum level of lipoproteins and the expressions of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF) were detected by ELISA. Hematoxylin–eosin (HE) staining of corpus cavernosum and measurement of penis length were utilized to assessment erectile function. Western blot was used.

Results: TC, TG, LDL, and non-HDL-C in serum were up-regulated, while HDL level was attenuated. After treatment, the serum lipid level recovered. From the ICP/MAP values, the erectile function of both two treatment groups recovered. The expression of PDE5A was up-regulated, while the levels of eNOS and cGMP were suppressed after surgery. The length of penis was decreased, and corpus cavernosum was damaged following HLP and stroke. However, the erectile function was recovered after treatment.

Conclusion: Stroke combined HLP caused ED through NO-cGMP-PDE5 pathway.     

2000例健康体检者血尿酸血脂水平的调查

目的了解中大五院健康体检者的血尿酸(UA)、血清甘油三酯(TG)和总胆固醇(TC)水平与性别、年龄的关系。方法对2000例体检者检查资料进行整理分析,按性别、年龄分组,用酶法检测体检者血清尿酸、甘油三酯、总胆固醇水平,进行调查分析。结果 UA、TG和TC水平总趋势均随着年龄增长而逐渐增高(P<0.05),50-岁年龄组各项指标显著高于其他年龄组(P<0.01)。血尿酸男性平均值为381.5±86.3μmol/L,女性为308.3±67.5μmol/L,各年龄组男性均明显高于女性,有非常显著性差异(P<0.01)。TG和TC各年龄组男性均明显高于女性,有非常显著性差异(P<0.01)。结论血尿酸、血脂水平与年龄因素有关。随年龄增长,尿酸血脂水平升高,30岁以上年龄组各项指标均显著高于30岁以下年龄组,提示年龄从30岁开始预防痛风和动脉硬化有重要意义。     

尿微量白蛋白、超敏C反应蛋白和低密度脂蛋白胆固醇在糖尿病肾病检测中的意义

目的 探讨尿微量白蛋白(mALB)、超敏C反应蛋白(hsCRP)和低密度脂蛋白胆固醇(LDL-C)与糖尿病肾病(diabetic nephropathy,DN)的关系.方法 测定185例DN患者的mALB、hsCRP、LDL-C水平,根据尿白蛋白排泄率分为正常蛋白尿组、微量白蛋白尿组、临床蛋白尿组,统计各组尿mALB、hsCRP、LDL-C水平;以100例健康检查者为对照组.结果 DN各组尿mALB、hsCRP、LDL-C水平均高于对照组,DN各组hsCRP、尿mALB水平有显著差异(P<0.05).结论 hsCRP、尿mALB和LDL-C与2型糖尿病肾病的发生、发展有密切联系;hsCRP和尿mALB在早期诊断DN方面优于LDL-C.     

氧自由基、动脉粥样硬化与有氧运动

分析了氧自由基致脂质过氧化作用是促进动脉粥样硬化发生、发展的重要原因；并提出有氧运动预防、延缓动脉粥样硬化的重要机理之一是有效地提高机体清除自由基损害的能力、避免血管内皮细胞受损、血小板聚集。     

Repression and other Forms of Cognitive Evasiveness: Implications for Stress Symptoms in College Students

Abstract

Lazarus has proposed that palliative defenses against threat that interfere with direct efforts to alleviate the threat may prove maladaptive. Three evasive cognitive attributes that circumvent awareness of threat were studied to determine whether they related to the prevalence of stress symptoms in college students. Repression (selective forgetting of threatening material), awareness of the repressive defense, and internal scanning (breadth of association to cues) were considered. College students of both sexes who engaged in evasive cognitive activity reported more stress symptoms than those who did not, with a progressive increase in stress as increasingly homogeneous groups were considered. Students who defended themselves by repression experienced more stress than those who did not. Repressors who were the least aware of their use of this defense reported even more stress. Unconscious repressors who were the least reflective (narrow scanners) showed the highest frequency of stress symptoms.     

Nonspecific Urethritis: Its Current Status

Abstract

The etiology, epidemiology, clinical presentation, diagnosis, and treatment of nonspecific urethritis (N.S.U.) is discussed. Chlamydia seems to be responsible for approximately 40–50% of cases while the etiology of the remainder remains obscrue. There seems to be reasonably good evidence for venereal transmission as well as for treatment of the female partner whether symptomatic or asymptomatic.

Tetracyline given for 21 days or oxytetracycline given for four days seem to be the most effective first line treatment regimens at this time.

Complications which include prostatitis, epididymitis, urethral stricture, and Reiter's Syndrome, are discussed. It appears as though there is a reasonable possibility that Reiter's Syndrome is a separate entity (or immunological sequela) rather than a complication.