Properties of the weighted log‐rank test in the design of confirmatory studies with delayed effects

Proportional hazards are a common assumption when designing confirmatory clinical trials in oncology. This assumption not only affects the analysis part but also the sample size calculation. The presence of delayed effects causes a change in the hazard ratio while the trial is ongoing since at the beginning we do not observe any difference between treatment arms, and after some unknown time point, the differences between treatment arms will start to appear. Hence, the proportional hazards assumption no longer holds, and both sample size calculation and analysis methods to be used should be reconsidered. The weighted log‐rank test allows a weighting for early, middle, and late differences through the Fleming and Harrington class of weights and is proven to be more efficient when the proportional hazards assumption does not hold. The Fleming and Harrington class of weights, along with the estimated delay, can be incorporated into the sample size calculation in order to maintain the desired power once the treatment arm differences start to appear. In this article, we explore the impact of delayed effects in group sequential and adaptive group sequential designs and make an empirical evaluation in terms of power and type‐I error rate of the of the weighted log‐rank test in a simulated scenario with fixed values of the Fleming and Harrington class of weights. We also give some practical recommendations regarding which methodology should be used in the presence of delayed effects depending on certain characteristics of the trial.     

LLSM在群体判断中的推广和应用

首先分析了对数最小二乘排序法的特点,说明它是一种值得重视的好方法;并进一步阐述了这一方法的基本原理,着重地对群体判断下求加权的综合排序向量的方法进行了严密的数学推导;提出了在加权的综合排序中权重系数确定的新見解,并举例子以解释。     

海上救助公约的发展及其主要影响

1989年通过的国际救助公约对传统的“无效果无报酬”原则所作的例外规定,引起了海运界和贸易界的极大关注,从而导致某些国际规则和国内法的修订。本文运用比较的方法对海上救助公约的发展及其对英国劳氏标准救助契约、国际共同海损理算规则和我国海商法的影响作了论述,并且提出了我国当前海商法应作修改补充的几点建议。     

Semi-parametric estimation of ROC curves based on binomial regression modelling

This paper presents a method of estimating a receiver operating characteristic (ROC) curve when the underlying diagnostic variable X is continuous and fully observed. The new method is based on modelling the probability of response given X , rather than the distribution of X given response. The method offers advantages in modelling flexibility and computational simplicity. The resulting ROC curve estimates are semi-parametric and can, in principle, take an infinite variety of shapes. Moreover, model selection can be based on standard methods within the binomial regression framework. Statistical accuracy of the curve estimate is provided by a simply implemented bootstrap approach.     

WEIGHTED SUMS OF NEGATIVELY ASSOCIATED RANDOM VARIABLES

In this paper, we establish strong laws for weighted sums of negatively associated (NA) random variables which have a higher‐order moment condition. Some results of Bai Z.D. & Cheng P.E. (2000) [Marcinkiewicz strong laws for linear statistics. Statist. and Probab. Lett. 43, 105–112,] and Sung S.K. (2001) [Strong laws for weighted sums of i.i.d. random variables, Statist. and Probab. Lett. 52, 413–419] are sharpened and extended from the independent identically distributed case to the NA setting. Also, one of the results of Li D.L. et al. (1995) [Complete convergence and almost sure convergence of weighted sums of random variables. J. Theoret. Probab. 8, 49–76,] is complemented and extended.     

一类多元Gauss-Weierstrass算子线性组合的加权逼近

该文给出了一类多元Gauss-Weierstrass算子线性组合加Jacobi权在一致逼近下的正、逆定理和逼近阶的特征刻划     

组合预测误差信息矩阵研究

研究组合预测误差信息矩阵的结构与组合预测方法性质之间的联系,首次提出冗余信息概念,对最优组合预测方法的组合结构进行了研究。     

谈普通高校体育课程改革思路

为贯彻《全国普通高等学校体育课程教学指导纲要》精神,结合当前高校体育教学实际,通过调查研究、经验总结等方法,对普通高校体育课程改革中存在的一些问题进行了分析,着重研究和探讨了深化改革的思路和途径,提出了改革大学体育课程建设的建议,以促进学校体育教学改革的进一步深化。