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1.
Stuart G. Baker Barnett S. Kramer 《Journal of the Royal Statistical Society. Series C, Applied statistics》2005,54(5):941-954
Summary. When evaluating potential interventions for cancer prevention, it is necessary to compare benefits and harms. With new study designs, new statistical approaches may be needed to facilitate this comparison. A case in point arose in a proposed genetic substudy of a randomized trial of tamoxifen versus placebo in asymptomatic women who were at high risk for breast cancer. Although the randomized trial showed that tamoxifen substantially reduced the risk of breast cancer, the harms from tamoxifen were serious and some were life threaten-ing. In hopes of finding a subset of women with inherited risk genes who derive greater bene-fits from tamoxifen, we proposed a nested case–control study to test some trial subjects for various genes and new statistical methods to extrapolate benefits and harms to the general population. An important design question is whether or not the study should target common low penetrance genes. Our calculations show that useful results are only likely with rare high penetrance genes. 相似文献
2.
陈红 《电子科技大学学报(社会科学版)》2002,4(3):44-47
本文着重在课程设计 ,教学特点 ,以及硬件环境上就加拿大毅伟管理学院和电子科技大学的MBA教育进行了对比分析 ,并对我校的MBA教育提出了几点建议 相似文献
3.
传统语法将动词分为及物动词和不及物动词,已不足以反映动词的特性。从生成语法的角度对英汉非宾格动词进行比较之后,将有利于学习和掌握英汉互译。 相似文献
4.
One of today's most frequently discussed topics in the business world is how to escape from the intense Red Ocean and how to create an uncontested Blue Ocean. However, because there are few practical guidelines available on this topic, we will introduce a case study of a third-party logistics (3PL) provider, CJ-Global Logistics Service (CJ-GLS), to show how it aspires to be a leader in the newly introduced 3PL industry in South Korea. CJ-GLS is a latecomer in the logistics industry, and its resources, such as the number of trucks and warehouses, are relatively small in comparison to those of established companies. But, it has achieved a distinct competitive advantage through innovative information technology (i.e., RFID—radio frequency identification), which has enabled it to create an uncontested market space, electronic logistics business. One remarkable fact about CJ-GLS is that its swift growth comes not from attracting competitors’ customers from the existing Red Ocean market but from creating a Blue Ocean market (3PL market), which previously existing incumbents ignored, and also from constructing a new business model founded on a RFID-based, ubiquitous-oriented 3PL system. Analyzed through a Four Actions Framework and characterized as Blue Ocean, this case study provides valuable information on how a company reinforces its competitive advantage from the Red Ocean while it transitions into a Blue Ocean by utilizing advanced information communication technologies. 相似文献
5.
Hadi Emami 《统计学通讯:理论与方法》2014,43(6):1050-1060
To assess the influence of observations on the parameter estimates, case deletion diagnostics are commonly used in linear regression models. For linear models with correlated errors we study the influence of observations on testing a linear hypothesis using single and multiple case deletions. The change in likelihood ratio test and F test theoretically is derived and it is shown these tests to be completely determined by two proposed generalized externally studentized residuals. An illustrative example of a real data set is also reported. 相似文献
6.
Siobhan E. Laird 《Australian Social Work》2017,70(4):417-428
Australia and the United Kingdom have mandatory systems of case reviews, which are conducted whenever a child known to welfare or health services has died or been seriously harmed due to maltreatment. In the United Kingdom those conducting case reviews are required to involve family members in their deliberations. This study employed discourse analysis to examine the representation of family voices in 41 Overview Reports of Serious Case Reviews undertaken in England and published during 2014. The findings revealed that the contributions of family members were generally relegated or their legitimacy undercut by the positivist framing of most overview reports. However, the research also identified how the framing of family contributions within an interpretivist paradigm could engender highly complex understanding of deficiencies in child protection systems and lead to crucial new learning for professionals. 相似文献
7.
This paper explores absorptive capacity metaroutines in a financial organization that experienced a large-scale misappropriation episode. We selected an instrumental case and collected individual semi-structured interviews, on-site nonparticipant observations, and documents to better understand the combination of absorptive capacity in organizational contexts. Findings revealed that the magnitude of organizational disruptions and time constraints influenced absorptive capacity metaroutines. The magnitude of organizational disruptions related to the intensity of required change for innovation adoption and the persistence of outcomes, while time constraints influenced the degree of involvement and cohesiveness of organizational members. In addition, findings showed that the combination of absorptive capacity metaroutines experienced asymmetries and had incremental and cumulative features. This work extends current theorizations of absorptive capacity conceptualized from a micro-foundation perspective as a collection of external and internal metaroutines and provides a means to start understanding potential factors that influence the combination of absorptive capacity metaroutines. Implications for theory and practice are discussed, and suggestions for future research are offered. 相似文献
8.
问题式学习教学模式以建构主义为基础,认为学生是知识意义的主动建构者,教师只是意义建构的帮助者和促进者。这一基本理念与社会工作"助人自助"核心理念,以及社会工作强调案主与工作者平等专业关系的要求具有诸多共通之处。通过对问题式个案工作课程的教学设计,学生不仅收获了专业理论与专业知识,更是通过问题式学习过程深化了专家价值观的认同,以及对社会工作实务开展具体过程的理解。 相似文献
9.
10.
董青 《陕西学前师范学院学报》2016,32(1):130-133
在界定幼儿园实际教育成本含义的基础上,确认其成本项目包含人员支出、公用支出、固定资产折旧和土地使用成本,以此为基础构建了幼儿园实际教育成本计量模型,并以佛山市某幼儿园为例核算出该幼儿园的实际教育成本。通过该园实际教育成本与标准教育成本的比较,发现该幼儿园教育经费投入不足且投入结构不合理,将来应重点增加人员投入。 相似文献