Growth hormone,somatomedins and men's health

According to current basic science as well as the clinical literature, human growth hormone has become an important topic in the field of anti-aging medicine. It is well known that the administration of human growth hormone compensates for the dwarfism syndrome in growth hormone-deficient children and growth hormone is also established as a substitution therapy for adults with pituitary deficiency. The effects mediated by growth hormone comprise an increase in muscle mass, a decrease in body fat, improved physical condition, oxygen consumption and overall quality of life, an improvement of the ratio of high-density lipoprotein to low-density lipoprotein, as well as an increase in bone density. Due to the insulin antagonistic effect of growth hormone as well as its insulin-like growth factor-1-mediated mitogenic effect, there is reason to doubt the safety of administering growth hormone outside the framework of approved indications. In an ongoing study, we are evaluating whether growth hormone and somatomedins might be of importance in the regulation of male sexual performance, including penile erection.     

USING SHORT-TERM DEDICATION FOR SCHEDULING MULTIPLE PRODUCTS ON PARALLEL MACHINES

In a multiproduct, parallel machine environment, it may be beneficial to dedicate one or more of the machines to a single product for consecutive time periods. However, previous lot-sizing and scheduling models usually do not allow for such short-term dedication. This paper presents a mixed-integer programming model that allows for short-term dedication in scheduling parallel machines serving multiple products with dynamic demands. It also describes a Lagrangian-based algorithm for solving such scheduling problems. An experiment verifies the effectiveness of the algorithm and demonstrates the importance of allowing for short-term dedication. Capacity utilization, one of six factors investigated, greatly affects the use of dedication. A strong interaction effect between the number of machines and the number of products is also seen with respect to the usefulness of short-term dedication. A measure of estimated production frequency incorporates these two factors along with magnitudes of periodic demands. This measure has a strong relationship with the amount of short-term dedication used in solutions. Operations managers employing parallel machines could use the experimental results in deciding whether to use short-term dedication to reduce costs.