PEDF 5 inhibition in erectile dysfunction

Dehydroepiandrosterone (DHEA), an adrenal steroid in humans, shows a certain anticarcinogenic effect in rat liver when it is administered simultaneously with strong carcinogens such as N-nitrosomorpholine (NNM). On the other hand, DHEA is an hepatocarcinogen in the rat when administered at high doses for more than 18 months. The hepatocellular tumors arise from amphophilic cell foci and exhibit a well-differentiated pheno-type. Wlien administered subsequent to NNM, DHEA acts as a tumor promoter in rat liver. Preneoplastic lesions of the glycogenotic/basophilic cell lineage induced by NNM are modulated to amphophilic lesions by DHEA. Female animals are more sensitive than males in respect of the carcinogenic and tumor-enhancing effect of DHEA. The higher sensitivity in females may be due to higher blood levels of DHEA andlor different metabolism and elimination of the drug, as compared to males. DHEA markedly induces cytochrome P450IVA, particularly in the liver of male rats. This effect may explain the rapid metabolism and elimination of the substance and the lower carcinogenicity in males. Both preneoplastic amphophilic foci and neoplasms are characterized by a strong proliferation of mitochondria. DHEA also induces peroxisome proliferation and susceptibility to lipid peroxidation in both genders. Furthermore, DHEA causes a reduction in activity and expression of key enzymes of carbohydrate metabolism and of glycogen content in the liver, which may be related to modulation of hepatocarcinogenesis.     

Gender,labour and the law: the nexus of domestic work,human trafficking and the informal economy in the United Arab Emirates

Based on ethnographic fieldwork with female migrants in the United Arab Emirates, the focus of this article is on the confluence of human trafficking discourses, gendered migration, domestic work and sex work in the UAE. I explore three main findings. First, domestic work and sex work are not mutually exclusive. Second, women choose to enter sex work in preference to domestic work because of poor working conditions in the latter. Third, global policies on human trafficking that seek to restrict female migration have inspired female migrants in the Gulf in search of higher wages and increased autonomy to look for employment in the informal economy. Employing a theoretical lens that emphasizes structural violence, the article chronicles the individual and macro social factors structuring the transition of female migrants from the formal economy of domestic and care work into the informal economy of sex work.     

Psychoanalytic Challenges: A Contribution to the New Sexual Agenda

Behind its conservative facade and the rigidityof much of its clinical practice, psychoanalysis retainsa disruptive attitude toward conventional discourses ongender and sexuality. This attitude derives from psychoanalysis capacity to look awry atexperience and consequently to undermine notions offixed identity, including sexual identity. Incontemporary work, much of the debate on psychoanalysisdisruptive consciousness, particularly among feminists,has centered on the contribution of Lacanian thinkingand in particular on the question of whether Lacanoffers a more rigorous alternative to object relational accounts of gender identity and sexualdifference. In this paper, the debate on psychoanalysiscontribution to the new sexual agenda isintroduced and furthered by exploration of the notion ofidentification as used first in some non-Lacanian work byJessica Benjamin, and then in a classic seminar of Lacans. It is suggested that both Benjamin and Lacan offerinsights into the provisional nature ofadoption of specific sexual identities and that acontinuing critical contribution from psychoanalysis canbe found in this work.     

Evaluation of sex hormone levels and some metabolic factors in men with coronary atherosclerosis

Background Because of the great controversy over the role of androgens in the pathogenesis of atherosclerosis, we investigated the relationship between serum sex hormone levels and angiographically confirmed coronary artery disease in men.

Material and methods We investigated 86 men aged 40–60 years, 56 with coronary artery disease and 30 healthy men, matched by age, as a control group. Body mass index and waist to hip ratio were calculated and total body fat mass and percentage of abdominal deposit were investigated by dual-energy X-ray absorptiometry (Dpx (?+?) Lunar, USA). The serum levels of sex hormones and insulin were measured using commercial radioimmunoassay and IRMA (by SHBG) kits (DPC, USA). The serum levels of lipids and glucose were assessed by means of enzymatic methods.

Results Men with coronary artery disease had lower total testosterone levels (17.01?±?6.42 vs. 19.37?±?6.58?nmol/l; p?<?0.05), testosterone/estradiol ratio (228.5?±?88.5 vs. 289.8?±?120.1; p?<?0.05) and free androgen index (FAI) (59.49?±?14.79 vs. 83.03?±?25.81; p?<?0.0001), and higher levels of estrone (49.5?±?27.7 vs. 36.6?±?12.7?pg/ml) than men in the control group. Moreover, men with coronary artery disease were more insulin-resistant than controls and had an atherogenic lipid profile. There was an inverse correlation (p?<?0.05) between testosterone level and serum level of glucose (r?=??0.29), triglycerides (r?=??0.37), body mass index (r?=??0.55), waist (r?=??0.43), total body fat mass (r?=??0.3) and fasting insulin resistance index. A significant positive association (p?<?0.05) was found between testosterone and the quantitative insulin sensitivity check index and high density lipoprotein cholesterol level in serum (r?=?0.26).

Conclusions Low levels of total testosterone, testosterone/estradiol ratio and free androgen index and higher levels of estrone in men with coronary artery disease appear together with many features of metabolic syndrome and may be involved in the pathogenesis of coronary atherosclerosis.     

A comparison of HIV risk practices among unprotected sex-seeking older and younger men who have sex with other men

Purpose: In recent years, much attention has been devoted to understanding the HIV risk behaviors of younger men who have sex with men (MSM). Recent data suggest that HIV is becoming an increasing problem for older adults, but little attention has been devoted to understanding their HIV risk behaviors or the factors that underlie their risk taking. This study provides a comparison of these issues among younger and older MSM. Methods: The data come from a subset of younger (ages 18–39, n?=?113) and older (ages 50+, n?=?109) men participating in a national study of 332 men who use the Internet to find other men for unprotected sex. Men were sampled randomly from 16 websites. Data were collected via telephone interviews conducted in 2008 and 2009. Results: Younger and older men reported comparable involvement in HIV risk, including involvement in unprotected sex, proportion of sex acts involving internal ejaculation, number of times having anonymous sex, and number of times having multiple-partner sex. Generally speaking, the factors underlying the risk practices of younger and older men were quite different (e.g. self-esteem and condom use self-efficacy for younger men, versus HIV serostatus and depression for older men). Conclusions: Older MSM using the Internet to find partners for unprotected sex engage in high rates of behaviors that place them at risk for contracting or transmitting HIV. They were just as likely as their younger counterparts to practice these behaviors. The factors “fueling” involvement in risk generally differ for older and younger men, thereby warranting the development of age-specific HIV interventions that can take into account the unique life circumstances and needs of older MSM.     

'Land of the free'? Circulating human rights and narrated lives in the United States

Abstract

In the 50 years during which human rights has gained an international currency, personal narratives have become one of the most potent vehicles for advancing human rights claims. This is particularly true in the United States where personal narratives attesting to human rights violations frequently gain wide exposure through mass publication and publicity, media circulation, and global information flows. This article explores the circulation of human rights narratives in the United States, examining some of the ways that stories enter into public discourse through published life narratives, television talk shows, news reports, campus lectures and publicity tours, websites, and the like, and are taken up by popular and academic audiences, spurring debates within the fields of legal and political theory, international relations, religion, morality and ethics, often far removed from the originating event or site of human rights violation. The article considers the many intended and unintended effects of this circulation on storytellers, their audiences, and the campaigns they represent.     

Sex and aging in the city: Singapore

A survey was carried out on 307 healthy men and 774 women, aged between 30 and 70 years to evaluate the determinants of sex life in the highly urbanized Singapore population. The results showed that significantly more women (28.8%) as compared to men (16.3%) were currently sexually inactive. The main reason for sexual inactivity for women was being divorced or widowed (37.9%) and for men, the loss of interest in sex (42.8%). Relationship problems and being stressed out in life were the next two most common reasons for both men and women. Coital frequency for men and women between the ages of 30 and 55 years averaged about five to six times monthly and was significantly reduced to about three times monthly in those above 55 years old. More men (25.7%) wanted to have more frequent sex than women (5.4%), but were unable to fulfill their desire and the primary reason was that they were too stressed out in life. Results from this study revealed that sex life is determined not only by physiological, but also cultural, social and lifestyle factors. In Singapore, lifestyle factors accounted largely for sexual inactivity, and the inability to fulfill the desire for more frequent sex. The term ‘lifestyle impotency’ was coined to describe the group of men and women who were too stressed out in life to have sex. Therefore, there is a need to evolve a paradigm for the management of sexual dysfunctions by taking into account the underlying etiological factors which, as we have shown, may not be resolved by pharmaceutical interventions.     

Estradiol in elderly men

The role of estrogens in male physiology has become more evident, as a consequence of the discovery of human models of estrogen deficiency such as estrogen resistance or aromatase deficiency. In males, testosterone is the major source of plasma estradiol, the main biologically active estrogen, only 20% of which is secreted by the testes. Plasma estrone, 5% of which is converted to plasma estradiol, originates from tissue aromatization of, mainly adrenal, androstenedione. The plasma concentration of estradiol in males is 2-3 ng/dl and its production rate in blood is 25-40 μg/24 h; both of these values are significantly higher than in postmenopausal women. Plasma levels of estradiol do not necessarily reflect tissue-level activity as peripherally formed estradiol is partially metabolized in situ; thus, not all enters the general circulation, with a fraction remaining only locally active. Of the factors influencing plasma estradiol levels, plasma testosterone is a major determinant. However, the age-associated decrease in testosterone levels is scarcely reflected in plasma estradiol levels, as a result of increasing aromatase activity with age and the age-associated increase in fat mass. Free and bioavailable estradiol levels do decrease modestly with age as does the ratio of free testosterone to free estradiol, the latter testifying to the age-associated increasewd aromatization of testosterone. Estradiol levels are highly significantly positively related to body fat mass and more specifically to subcutaneous abdominal fat, but not to visceral (omental) fat. Indeed, aromatase activity in omental fat is only one-tenth of the activity in gluteal fat. Estrogens in males play an important role in the regulation of the gonadotropin feedback, several brain functions, bone maturation, regulation of bone resorption and in lipid metabolism. Moreover, they affect skin metabolism and are an important factor determining sex interest in man.