Testing Inference in Inflated Beta Regressions under Model Misspecification

We consider testing inference in inflated beta regressions subject to model misspecification. In particular, quasi-z tests based on sandwich covariance matrix estimators are described and their finite sample behavior is investigated via Monte Carlo simulations. The numerical evidence shows that quasi-z testing inference can be considerably more accurate than inference made through the usual z tests, especially when there is model misspecification. Interval estimation is also considered. We also present an empirical application that uses real (not simulated) data.     

A study of quadratic inference functions with alternative weighting matrices

Quadratic inference function (QIF) is an alternative methodology to the popular generalized estimating equations (GEE) approach, it does not involve direct estimation of the correlation parameter, and thus remains optimal even if the working correlation structure is misspecified. The idea is to represent the inverse of the working correlation matrix by a linear combination of some basis matrices. In this article, we present a modification of QIF with a robust variance estimator of the extended score function. Theoretical and numerical results show that the modified QIF attains better efficiency and achieves better small sample performance than the original QIF method.     

Estimating stellar-oscillation-related parameters and their uncertainties with the moment method

Summary.  The moment method is a well-known astronomical mode identification technique in asteroseismology which uses a time series of the first three moments of a spectral line to estimate the discrete oscillation mode parameters l and m . The method, in contrast with many other mode identification techniques, also provides estimates of other important continuous parameters such as the inclination angle α and the rotational velocity v _e. We developed a statistical formalism for the moment method based on so-called generalized estimating equations. This formalism allows an estimation of the uncertainty of the continuous parameters, taking into account that the different moments of a line profile are correlated and that the uncertainty of the observed moments also depends on the model parameters. Furthermore, we set up a procedure to take into account the mode uncertainty, i.e. the fact that often several modes ( l ,  m ) can adequately describe the data. We also introduce a new lack-of-fit function which works at least as well as a previous discriminant function, and which in addition allows us to identify the sign of the azimuthal order m . We applied our method to star HD181558 by using several numerical methods, from which we learned that numerically solving the estimating equations is an intensive task. We report on the numerical results, from which we gain insight in the statistical uncertainties of the physical parameters that are involved in the moment method.     

论《英雄不过是三明治》的叙事特色

美国黑人女作家爱丽丝·奇尔德里斯的小说《英雄不过是三明治》主要有两个叙事特点,一是使用多人第一人称视角观察和叙述故事,二是在相应章节间穿插新闻、广告等非虚构材料,把虚构文本和纪实文本融为一体,为表现小说的主题提供了有力的支撑,使小说具有鲜明的叙事特色和独到的艺术效果。     

A marginal regression model for multivariate failure time data with a surviving fraction

A marginal regression approach for correlated censored survival data has become a widely used statistical method. Examples of this approach in survival analysis include from the early work by Wei et al. (J Am Stat Assoc 84:1065–1073, 1989) to more recent work by Spiekerman and Lin (J Am Stat Assoc 93:1164–1175, 1998). This approach is particularly useful if a covariate’s population average effect is of primary interest and the correlation structure is not of interest or cannot be appropriately specified due to lack of sufficient information. In this paper, we consider a semiparametric marginal proportional hazard mixture cure model for clustered survival data with a surviving or “cure” fraction. Unlike the clustered data in previous work, the latent binary cure statuses of patients in one cluster tend to be correlated in addition to the possible correlated failure times among the patients in the cluster who are not cured. The complexity of specifying appropriate correlation structures for the data becomes even worse if the potential correlation between cure statuses and the failure times in the cluster has to be considered, and thus a marginal regression approach is particularly attractive. We formulate a semiparametric marginal proportional hazards mixture cure model. Estimates are obtained using an EM algorithm and expressions for the variance–covariance are derived using sandwich estimators. Simulation studies are conducted to assess finite sample properties of the proposed model. The marginal model is applied to a multi-institutional study of local recurrences of tonsil cancer patients who received radiation therapy. It reveals new findings that are not available from previous analyses of this study that ignored the potential correlation between patients within the same institution.     

Maximizing generalized linear mixed model likelihoods with an automated Monte Carlo EM algorithm

Two new implementations of the EM algorithm are proposed for maximum likelihood fitting of generalized linear mixed models. Both methods use random (independent and identically distributed) sampling to construct Monte Carlo approximations at the E-step. One approach involves generating random samples from the exact conditional distribution of the random effects (given the data) by rejection sampling, using the marginal distribution as a candidate. The second method uses a multivariate t importance sampling approximation. In many applications the two methods are complementary. Rejection sampling is more efficient when sample sizes are small, whereas importance sampling is better with larger sample sizes. Monte Carlo approximation using random samples allows the Monte Carlo error at each iteration to be assessed by using standard central limit theory combined with Taylor series methods. Specifically, we construct a sandwich variance estimate for the maximizer at each approximate E-step. This suggests a rule for automatically increasing the Monte Carlo sample size after iterations in which the true EM step is swamped by Monte Carlo error. In contrast, techniques for assessing Monte Carlo error have not been developed for use with alternative implementations of Monte Carlo EM algorithms utilizing Markov chain Monte Carlo E-step approximations. Three different data sets, including the infamous salamander data of McCullagh and Nelder, are used to illustrate the techniques and to compare them with the alternatives. The results show that the methods proposed can be considerably more efficient than those based on Markov chain Monte Carlo algorithms. However, the methods proposed may break down when the intractable integrals in the likelihood function are of high dimension.     

案例教学法结合Sandwich教学法在法医临床学实验教学中的运用

法医临床学实验教学内容繁杂,采用传统教学方法往往不能达到较好的教学效果。笔者将案例教学法结合Sandwich教学法引入法医临床学实验教学实践中,充分调动了学生学习的主动性、积极性,同时培养了学生表达和沟通能力、分析问题和解决问题的能力;该方法的运用进一步提高了法医临床学实验教学的教学质量,对学生综合能力的培养起到了积极作用。     

Analysis of proportions for clustered binary data in the presence of unequal dispersions

This paper investigates the test procedures for testing the homogeneity of the proportions in the analysis of clustered binary data in the context of unequal dispersions across the treatment groups. We introduce a simple test procedure based on adjusted proportions using a sandwich estimator of the variance of the proportion estimators obtained by the generalized estimating equations approach of Zeger and Liang (1986) [Biometrics 42, 121-130]. We also extend the exiting test procedures of testing the hypothesis of proportions in this context. These test procedures are then compared, by simulations, in terms of size and power. Moreover, we derive the score test for testing the homogeneity of the dispersion parameters among several groups of clustered binary data. An illustrative application of the recommended test procedures is also presented.     

Multilevel modelling of complex survey data

Summary.  Multilevel modelling is sometimes used for data from complex surveys involving multistage sampling, unequal sampling probabilities and stratification. We consider generalized linear mixed models and particularly the case of dichotomous responses. A pseudolikelihood approach for accommodating inverse probability weights in multilevel models with an arbitrary number of levels is implemented by using adaptive quadrature. A sandwich estimator is used to obtain standard errors that account for stratification and clustering. When level 1 weights are used that vary between elementary units in clusters, the scaling of the weights becomes important. We point out that not only variance components but also regression coefficients can be severely biased when the response is dichotomous. The pseudolikelihood methodology is applied to complex survey data on reading proficiency from the American sample of the 'Program for international student assessment' 2000 study, using the Stata program gllamm which can estimate a wide range of multilevel and latent variable models. Performance of pseudo-maximum-likelihood with different methods for handling level 1 weights is investigated in a Monte Carlo experiment. Pseudo-maximum-likelihood estimators of (conditional) regression coefficients perform well for large cluster sizes but are biased for small cluster sizes. In contrast, estimators of marginal effects perform well in both situations. We conclude that caution must be exercised in pseudo-maximum-likelihood estimation for small cluster sizes when level 1 weights are used.     

Response surface characterization of the mechanical behavior of impact-damaged sandwich composites

In this research, Response Surface Methodology (RSM) is employed to characterize the influence of material configuration on the damage tolerance and residual strength characteristics of sandwich composites. Test specimens used were comprised of carbon-epoxy woven fabric facesheets, and Nomex honeycomb cores. The ranges of the material configuration used are typical of those employed in aircraft applications. A series of carefully selected tests were used to isolate the coupled influence of various combinations of the number of facesheet plies, core density, and core thickness on the damage formation and residual strength degradation due to normal impact. Response surface estimates suggest that impact damage development and residual strength degradation are highly material and lay-up configuration dependent. Increasing the core thickness for a specific number of facesheet plies resulted in decreasing the impact damage, whereas increasing the number of facesheet plies for a given core thickness resulted in enhancing the residual strength. The derived damage tolerance and residual strength models can lead to a better understanding of the mechanical behavior of the impact-damaged sandwich composites, and hence improve their design and expand their applications.