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1.
When a candidate predictive marker is available, but evidence on its predictive ability is not sufficiently reliable, all‐comers trials with marker stratification are frequently conducted. We propose a framework for planning and evaluating prospective testing strategies in confirmatory, phase III marker‐stratified clinical trials based on a natural assumption on heterogeneity of treatment effects across marker‐defined subpopulations, where weak rather than strong control is permitted for multiple population tests. For phase III marker‐stratified trials, it is expected that treatment efficacy is established in a particular patient population, possibly in a marker‐defined subpopulation, and that the marker accuracy is assessed when the marker is used to restrict the indication or labelling of the treatment to a marker‐based subpopulation, ie, assessment of the clinical validity of the marker. In this paper, we develop statistical testing strategies based on criteria that are explicitly designated to the marker assessment, including those examining treatment effects in marker‐negative patients. As existing and developed statistical testing strategies can assert treatment efficacy for either the overall patient population or the marker‐positive subpopulation, we also develop criteria for evaluating the operating characteristics of the statistical testing strategies based on the probabilities of asserting treatment efficacy across marker subpopulations. Numerical evaluations to compare the statistical testing strategies based on the developed criteria are provided. 相似文献
2.
Chulpan Gromova Rezeda Khairutdinova Dina Birman Aydar Kalimullin 《Intercultural Education》2019,30(5):495-509
ABSTRACTEducational institutions are an important setting where psychological, pedagogical, sociocultural, and language adaptation of immigrant children occurs. A number of teaching strategies, practices, approaches, and methods have been described in the literature. In the Russian context, such strategies have been called ‘technologies’. The purpose of the present exploratory study was to describe teaching technologies used by teachers in Russia when working with immigrant students in elementary schools. Responses of forty-five elementary school teachers to open-ended questions describing technologies they use when teaching children with migration backgrounds were analyzed using content analysis. Findings suggest that Russian elementary school teachers used ethno-cultural group, communicative technologies, games, individualized instruction, and differentiated teaching. Many approaches mentioned can be used inclusively with groups of immigrant and non-immigrant students. Importantly, while teachers supplemented classroom instruction with additional Russian language lessons, none mentioned specific techniques for teaching Russian as a non-native language. These findings are discussed in relation to teaching strategies described in the international literature focused on migrant students. Finally, implications for further research are discussed. 相似文献
3.
《European Management Journal》2020,38(5):736-749
Influence plays a key role in reaching consensus among multiple actors involved in project-based decision-making processes. While prior literature devotes considerable attention to describing influence, little attention has been paid to influence at the individual level of the strategic project manager within the context of megaprojects. This research intended to fill this knowledge gap by identifying and describing the influence strategies that a strategic project manager applies when implementing innovation strategies on megaprojects. A qualitative case study was used to examine the complex social processes involved in a major UK capital investment programme. The findings underline a critical subset of influence strategies, notably higher-management support, inspirational appeal and bargaining. The study proposes a utilitarian structure of social power comprising selective, supportive and executory power bases. 相似文献
4.
C. Eddie Palmer E. Joseph Savoie 《Sociological Practice: A Journal of Clinical and Applied Sociology》2002,4(1):89-97
Service-learning programs are not free from challenges brought about by lack of financial support, lack of widespread commitment from professors, community agencies, and recipients of service, and lack of knowledge and insight in students directly involved in such programs. While service-learning initiatives and programs serve positive functions for organizations and individuals, rhetorical accolades for service learning can distort or omit the realities of program implementation and sustained delivery. This paper specifically explores the following challenges connected to service-learning programs: (1) pedagogical difficulties; (2) student limitations; (3) time constraints; and (4) community cooperation. 相似文献
5.
韩国大企业集团的海外扩张战略 总被引:1,自引:0,他引:1
丁溪 《哈尔滨工业大学学报(社会科学版)》2002,4(4):64-66
自 70年代以来 ,韩国政府通过采取出口导向战略扶持大企业进军海外市场 ,带动了韩国经济的发展。韩国在短短的几十年里由一个农业国变成了一个新兴的工业化国家 ,经济总量居亚洲第三。在韩国经济快速发展中 ,大企业的强力出口、大举投资的海外扩张战略功不可没 相似文献
6.
文章介绍了近年来在美国、澳大利亚等国盛行的“体裁教学法”,评价了体裁和体裁分析理论,阐述了体裁分析的发展与特色,探讨了体裁分析法在商务语篇教学中的作用。 相似文献
7.
CRM的理念与实施中关键因素分析 总被引:1,自引:0,他引:1
何耀琴 《西南交通大学学报(社会科学版)》2002,3(3):77-80
随着市场环境、竞争环境的快速变化 ,企业的管理理念、服务观念开始发生重大转变 ,使得CRM(CustomerRelationshipManagement,客户关系管理 )成为当前热点。本文试从CRM在国内外的应用情况、CRM体现的管理理念、服务宗旨以及实施中应考虑的一些重要因素进行分析 相似文献
8.
赵欣 《内蒙古工业大学学报》2005,14(2):126-129,138
本调查以内蒙古工业大学非英语专业二年级的109名学生为样本,采取观察和问卷形式,考察非英语专业学生使用何种学习策略以及学习策略的使用频率.结果表明六种学习策略中,非英语专业学生最常用的策略是补偿策略,最不常用的策略是记忆策略.最后,作者指出本文的教学实践意义:即学习策略的培训应融于课堂教学中,其应用应体现于课堂教学活动中 相似文献
9.
战略联盟--企业竞争新模式 总被引:2,自引:0,他引:2
王竹青 《重庆工商大学学报(社会科学版)》2002,19(3):28-31
战略联盟是企业之间为了一定目的 ,通过一定方式组成的网络式联合体。面对日趋激烈的市场竞争和外部环境的变化 ,企业之间既竞争又合作 ,战略联盟是一种全新的企业竞争模式 相似文献
10.
刘爱华 《淄博师范高等专科学校学报》2007,(3)
叠词是汉语的一种修辞格,能带来特殊的语言表达效果。叠词形式多样、功能不一,在传达情感、强调意义和创造意境等方面颇具功效,其使用可促进语言形式和内容达到艺术统一。在结构工整严谨、对字词精炼传神、美学效果要求较高的汉语古诗词中,叠词起着不可忽视的作用。聚焦汉语古诗词中叠词的常见类型、特殊功能,关注其英译的策略原则是必要的。 相似文献