雄激素受体信号通路在前列腺癌中的表达调控

雄激素受体信号通路在前列腺癌的发生、发展过程中发挥重要作用,因此,一直是前列腺癌相关领域的研究热点。研究前列腺癌中雄激素受体信号通路的表达调控可以为前列腺癌的临床诊断、治疗以及进一步的研究提供科学依据。本文就雄激素受体信号通路激活与抑制方面的研究进展进行综述。     

Families in the Life Course: Interdependency of Roles,Role Configurations,and Pathways

Families are central in the unfolding life course. They have both internal and external dynamics that reflect and characterize the modern life span, and a life course perspective has particular utility for understanding the role and implications of families for individuals and society. The purpose of this paper is 3‐fold. First, we offer a family life course perspective that delineates core concepts of roles, role configurations, and pathways, specifies the links between them, and highlights the importance of linked lives and structural context. Second, we elaborate a latent class approach for modeling the multilayered dynamic interdependencies that characterize modern family life. Third, we provide an empirical example by considering the timing of childbearing, teen parenthood, and its place in the transition to adulthood using women's data from the National Longitudinal Survey of Youth 1979 (N= 2,191). We conclude by discussing further avenues of family research that are enhanced with a life course approach and complementary latent structure methodology.     

Random effects models for operational patient pathways

Patient flow modeling is a growing field of interest in health services research. Several techniques have been applied to model movement of patients within and between health-care facilities. However, individual patient experience during the delivery of care has always been overlooked. In this work, a random effects model is introduced to patient flow modeling and applied to a London Hospital Neonatal unit data. In particular, a random effects multinomial logit model is used to capture individual patient trajectories in the process of care with patient frailties modeled as random effects. Intuitively, both operational and clinical patient flow are modeled, the former being physical and the latter latent. Two variants of the model are proposed, one based on mere patient pathways and the other based on patient characteristics. Our technique could identify interesting pathways such as those that result in high probability of death (survival), pathways incurring the least (highest) cost of care or pathways with the least (highest) length of stay. Patient-specific discharge probabilities from the health care system could also be predicted. These are of interest to health-care managers in planning the scarce resources needed to run health-care institutions.     

On the significance of social control: Treatment‐entry pressures,self‐choice and alcohol and drug dependence criteria one year after treatment

Storbjörk J. On the significance of social control: treatment‐entry pressures, self‐choice and alcohol and drug dependence criteria one year after treatment This article explores how self‐choice and treatment‐entry pressures are associated with one‐year treatment outcome (dependence symptoms, 0–6, 12 months) among alcohol and drug misusers, respectively. Informal pressures (from family and friends), formal pressures (related to work, healthcare, social services, social allowances, child custody) and legal pressures (related to the police, criminal justice system, compulsory treatment) were analysed. A sample (N= 1,210) representative of the addiction treatment system of Stockholm County was interviewed when starting a new treatment episode and after one year. Regression analyses indicated that self‐choice and pressures are associated with outcome among alcohol misusers but not among drug misusers when controlling for background factors and severity. Self‐choice (without pressures) correlated with a good outcome (a lower number of dependence criteria). Pressures were generally associated with poorer outcome. Alcohol misusers who had experienced threats regarding child custody did better in comparison with those not experiencing such pressure. The difference in results by drug type and implications were discussed.     

国际关系的理论回归与基础路径——以国际制度理论为例

国际关系理论衰落的论调和担忧激励了理论创新。在诸多创新方式中,理论综合是重要的一种,具体包含了理论折中和理论合成,且主要发生在宏观范式之间或内部,由此形成了四种主要的理论综合方式:范式间折中或合成、范式内折中或合成。理论合成的严格理论与理论折中的实用性分析框架之间,还存在较多模糊地带。更多的研究既没有清晰的理论创造或运用,亦没有明确的折中分析框架。但是,这并不意味着国际关系"理论已逝"的论断已成事实。在理论合成与理论折中之间还存在一种理论综合的方式——理论回归,即从相关的多层次和多学科理论中拟合出简约且共性最大(或平均差异最小)的基础路径。所谓"基础路径"即介于宏观哲学元理论或思想传统与具体学科内理论之间的、若干相邻学科或理论共享的、具有一定范围内共识性的研究议题及解答思路。以国际制度研究为例,大量的经验研究虽然时常没有明确的理论地位,但并未完全脱离多层次的理论基础,而是逐渐形成超越具体学科及/或理论的五大基础路径:权力—结构、理性—功能、文化—建构、历史—阶级、反思—批判。     

关于推进鄂西生态文化旅游圈发展的思考

鄂西生态文化圈是湖北成为中部崛起战略支点中的重要内容,它将以优越的生态环境和厚重的文化资源为支撑,推动湖北的全面协调可持续发展,并在未来生态文明、绿色繁荣进程中抢占到先机。正确把握优势与不足,运用一切可用的科学手段,才能园满实现构建鄂西生态文化圈的根本目标。     

美国发展教师领导力的路径与方法探析

美国对教师领导力（teacher leadership）的研究发展至今已将近四十年，在教师发展领域仍是一个热点话题。一方面，美国通过提供发展教师领导力的教育培训、建立发展教师领导力的平台、实施发展教师领导力的计划等多种途径来促进教师领导力的发展；另一方面，美国又通过提高教师个人专业能力、发展有效的学校领导力、实施增加教师领导机会的政策和手段等多种方法来全方位地发展教师领导力。美国这种多途径、全方位地发展教师领导力的做法，为我国教师发展提供了重要的参考。     

Poultry and policy in Ghana: Lessons from the periphery of an agricultural policy system

We analyze poultry‐related policy documents from Ghana and ask how the problems identified and the actions proposed have changed over time. The analysis highlights the fact of limited and poor quality data, and associated uncertainty, ambiguity and poor specification of both problems and interventions. It also points to a long‐term commitment to intensive commercial production as the preferred pathway to deliver more animal protein. However, in the face of persistent feed constraints and economic liberalization, imports of frozen chicken have sky‐rocketed since the early 2000s, and a new pathway has come to dominate. We discuss this outcome and what it says more generally about policy around minor crops and livestock species.     

A latent class analysis of young adult gamblers from the Manitoba Longitudinal Survey of Young Adults

Informed by the Pathways Model, the current study utilized latent class analysis (LCA) to empirically derive subtypes of gamblers based on measures of impulsivity, anxiety, depression, drug use and alcohol dependence. The sample in this study (N = 566) was comprised of young adult gamblers (18–22 years of age) who participated in the Manitoba Longitudinal Survey of Young Adults (MLSYA). Multinomial regression was utilized to examine how demographic variables and participant scores on the Problem Gambling Severity Index (PGSI) predicted membership in gambler classes from the LCA. Results of the LCA revealed three classes of gamblers: emotionally vulnerable, non-problem and impulsive. Multinomial regression showed that older age (i.e. 20–22 years of age), lower income (< $20,000 per year), living independently and PGSI scores were associated with increased odds of being classified as an impulsive gambler. Identifying as European, living independently and PGSI scores were associated with increased odds of being grouped in the emotionally vulnerable class of gambler. These results suggest that young adult gamblers are not a homogeneous group but instead are best understood as falling into different subtypes based on shared characteristics outlined in the Pathways Model.