Asymptotic bias in the linear mixed effects model under non-ignorable missing data mechanisms

Summary.  In longitudinal studies, missingness of data is often an unavoidable problem. Estimators from the linear mixed effects model assume that missing data are missing at random. However, estimators are biased when this assumption is not met. In the paper, theoretical results for the asymptotic bias are established under non-ignorable drop-out, drop-in and other missing data patterns. The asymptotic bias is large when the drop-out subjects have only one or no observation, especially for slope-related parameters of the linear mixed effects model. In the drop-in case, intercept-related parameter estimators show substantial asymptotic bias when subjects enter late in the study. Eight other missing data patterns are considered and these produce asymptotic biases of a variety of magnitudes.     

Catalogue of Group Structures for Three-level Fractional Factorial Designs

Taguchi (1959) introduced the concept of split-unit design to sort the factors into different groups depending upon the difficulties involved in changing the levels of factors. Li et al. (1991) renamed it as split-plot design. Chen et al. (1993) have given a catalogue of small designs for two- and three-level fractional factorial designs pertaining to a single type of factors. Aggarwal et al. (1997) have given a catalogue of group structure for two-level fractional factorial designs developed under the concept of split-plot design. In this paper, an algorithm has been developed for generating group structure and possible allocations for various 3^n-k fractional factorial designs.     

Bayesian inference for a discretely observed stochastic kinetic model

The ability to infer parameters of gene regulatory networks is emerging as a key problem in systems biology. The biochemical data are intrinsically stochastic and tend to be observed by means of discrete-time sampling systems, which are often limited in their completeness. In this paper we explore how to make Bayesian inference for the kinetic rate constants of regulatory networks, using the stochastic kinetic Lotka-Volterra system as a model. This simple model describes behaviour typical of many biochemical networks which exhibit auto-regulatory behaviour. Various MCMC algorithms are described and their performance evaluated in several data-poor scenarios. An algorithm based on an approximating process is shown to be particularly efficient.     

Robust block bootstrap panel predictability tests*

This article develops two block bootstrap-based panel predictability test procedures that are valid under very general conditions. Some of the allowable features include cross-sectional dependence, heterogeneous predictive slopes, persistent predictors, and complex error dynamics, including cross-unit endogeneity. While the first test procedure tests if there is any predictability at all, the second procedure determines the units for which predictability holds in case of a rejection by the first. A weak unit root framework is adopted to allow persistent predictors, and a novel theory is developed to establish asymptotic validity of the proposed bootstrap. Simulations are used to evaluate the performance of our tests in small samples, and their implementation is illustrated through an empirical application to stock returns.     

On the statistical computation of the sample multiple correlation moefficient

Based on the recursive formulas of Lee (1988) and Singh and Relyea (1992) for computing the noncentral F distribution, a numerical algorithm for evaluating the distributional values of the sample squared multiple correlation coefficient is proposed. The distributional function of this statistic is usually represented as an infinite weighted sum of the iterative form of incomplete beta integral. So an effective algorithm for the incomplete beta integral is crucial to the numerical evaluation of various distribution values. Let a and b denote two shape parameters shown in the incomplete beta integral and hence formed in the sampling distribution functionn be the sample size, and p be the number of random variates. Then both 2a = p - 1 and 2b = n - p are positive integers in sampling situations so that the proposed numerical procedures in this paper are greatly simplified by recursively formulating the incomplete beta integral. By doing this, it can jointly compute the distributional values of probability dens function (pdf) and cumulative distribution function (cdf) for which the distributional value of quantile can be more efficiently obtained by Newton's method. In addition, computer codes in C are developed for demonstration and performance evaluation. For the less precision required, the implemented method can achieve the exact value with respect to the jnite significant digit desired. In general, the numerical results are apparently better than those by various approximations and interpolations of Gurland and Asiribo (1991),Gurland and Milton (1970), and Lee (1971, 1972). When b = (1/2)(n -p) is an integer in particular, the finite series formulation of Gurland (1968) is used to evaluate the pdf/cdf values without truncation errors, which are served as the pivotal one. By setting the implemented codes with double precisions, the infinite series form of derived method can achieve the pivotal values for almost all cases under study. Related comparisons and illustrations are also presented     

Influence measures in blocked designs of experiments with correlated errors

Diagnostics measures for detecting outliers in data from block designs of experiments with correlated errors are considered. Influence is often assessed by deleting suspected outlying observations. Autocorrelation of order one is considered to model correlation in each block. Cook-statistic is developed for detecting the effect of a single outlier, where results are illustrated with an example.     

Organizational identification as a mediator for the effects of psychological contract breaches on organizational citizenship behavior: Insights from the perspective of ethnic minority employees

This study examines the contribution of the psychological contract (PC) framework to the understanding of ethnic minority employees’ employment relationships. First, it tests the generalizability of PC types (transactional, relational, and balanced) observed in the general population to ethnic minority employees. Then, to further address the unique needs and motivators of minority employees, this study considers diversity-related PCs. It adopts social exchange theory to explain how transactional, relational, balanced, and diversity-related PC breaches predict organizational citizenship behavior (OCB). Moreover, it draws insights from social identity theory and examines the mediating role of organizational identification in the relationship between types of PC breach and OCB. Data from 361 Turkish employees working as ethnic minorities in Belgium indicate that relational and diversity-related PC breaches predict OCB partially via organizational identification while transactional and balanced PC breaches directly affect OCB.     

Some new constructions of circular balanced repeated measurements designs

Repeated measurements designs are widely used in medicine, pharmacology, animal sciences, and psychology. In this article, some infinite series are developed to generate the balanced repeated measurements designs for p (periods) even. For p odd, construction procedures are also described. Catalogues of the proposed designs are also presented for p = 5, 7, 9, when v ≤ 100.     

Modified linear discriminant analysis using block covariance matrix in high-dimensional data

Among many classification methods, linear discriminant analysis (LDA) is a favored tool due to its simplicity, robustness, and predictive accuracy but when the number of genes is larger than the number of observations, it cannot be applied directly because the within-class covariance matrix is singular. Also, diagonal LDA (DLDA) is a simpler model compared to LDA and has better performance in some cases. However, in reality, DLDA requires a strong assumption based on mutual independence. In this article, we propose the modified LDA (MLDA). MLDA is based on independence, but uses the information that has an effect on classification performance with the dependence structure. We suggest two approaches. One is the case of using gene rank. The other involves no use of gene rank. We found that MLDA has better performance than LDA, DLDA, or K-nearest neighborhood and is comparable with support vector machines in real data analysis and the simulation study.     

A Theory of Rational Choice under Ignorance

This paper contributes to a theory of rational choice for decision-makers with incomplete preferences due to partial ignorance, whose beliefs are representable as sets of acceptable priors. We focus on the limiting case of `Complete Ignorance' which can be viewed as reduced form of the general case of partial ignorance. Rationality is conceptualized in terms of a `Principle of Preference-Basedness', according to which rational choice should be isomorphic to asserted preference. The main result characterizes axiomatically a new choice-rule called `Simultaneous Expected Utility Maximization'. It can be interpreted as agreement in a bargaining game (Kalai-Smorodinsky solution) whose players correspond to the (extremal) `acceptable priors' among which the decision maker has suspended judgment. An essential but non-standard feature of Simultaneous Expected Utility choices is their dependence on the entire choice set. This is justified by the conception of optimality as compromise rather than as superiority in pairwise comparisons.