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1.
韩立军 《内蒙古工业大学学报》2002,21(1):50-52
本文给出一类非均匀弦的横向振动的最佳控制,推广了P C Park的结果。这一结果同样适用于同类型振动问题。 相似文献
2.
李海群 《长江大学学报(社会科学版)》2002,(2)
该电路设计简单、构思新颖 ,适合小批量测试小型电源变压器的空载电流、额定电流及次级空载电压、满载电压、负载电流等参数 相似文献
3.
We propose some estimators of noncentrality parameters which improve upon usual unbiased estimators under quadratic loss. The distributions we consider are the noncentral chi-square and the noncentral F. However, we give more general results for the family of elliptically contoured distributions and propose a robust dominating estimator. 相似文献
4.
Jan C. H. van Eijkeren 《Risk analysis》2002,22(1):159-173
A mechanistic model is presented describing the clearance of a compound in a precision-cut liver slice that is incubated in a culture medium. The problem of estimating metabolic rate constants in PBPK models from liver slice experiments is discussed using identifiability analysis. From the identifiability problem analysis, it appears that in addition to the clearance, the compound's free fraction in the slice and the diffusion rate of the exchange of the compound between culture medium and liver slice should be identified. In addition, knowledge of the culture medium volume, the slice volume, the compound's free fraction, and octanol-water-based partition between medium and slice is presupposed. The formal solution for identification is discussed from the perspective of experimental practice. A formally necessary condition for identification is the sampling of parent compound in liver slice or culture medium. However, due to experimental limitations and errors, sampling the parent compound in the slice together with additional sampling of metabolite pooled from the medium and the slice is required for identification in practice. Moreover, it appears that identification results are unreliable when the value of the intrinsic clearance exceeds the value of the diffusion coefficient, a condition to be verified a posteriori. 相似文献
5.
Peter J. Robinson 《Risk analysis》1992,12(1):139-148
Because of the inherent complexity of biological systems, there is often a choice between a number of apparently equally applicable physiologically based models to describe uptake and metabolism processes in toxicology or risk assessment. These models may fit the particular data sets of interest equally well, but may give quite different parameter estimates or predictions under different (extrapolated) conditions. Such competing models can be discriminated by a number of methods, including potential refutation by means of strategic experiments, and their ability to suitably incorporate all relevant physiological processes. For illustration, three currently used models for steady-state hepatic elimination--the venous equilibration model, the parallel tube model, and the distributed sinusoidal perfusion model--are reviewed and compared with particular reference to their application in the area of risk assessment. The ability of each of the models to describe and incorporate such physiological processes as protein binding, precursor-metabolite relations and hepatic zones of elimination, capillary recruitment, capillary heterogeneity, and intrahepatic shunting is discussed. Differences between the models in hepatic parameter estimation, extrapolation to different conditions, and interspecies scaling are discussed, and criteria for choosing one model over the others are presented. In this case, the distributed model provides the most general framework for describing physiological processes taking place in the liver, and has so far not been experimentally refuted, as have the other two models. These simpler models may, however, provide useful bounds on parameter estimates and on extrapolations and risk assessments. 相似文献
6.
张秋勇 《绍兴文理学院学报》2002,22(7):97-100
运用机械动态参数测试仪 ,通过对THEMA剑杆织机的开口、引纬机构进行动态测试 ,利用计算机处理有关测试数据 ,分析和讨论了该机的主要技术参数 相似文献
7.
用递推方法论证了至少存在一条n次Bezier参数曲线与一元n次实数多项式函数完全等价。同时给出了将一元n次实纱多项式转换为完全等价的n次Bezier参数曲线的方法。 相似文献
8.
9.
本文通过对2F4.8制冷压缩机热力过程的计算机模拟,获得气阀参数对压缩机热力性能影响的数据资料,以改进气阀结构。经过试验证明,可提高压缩机制冷量和性能系数10%以上。 相似文献
10.
Formulae are provided that define the ‘bend points’, the beginning and end of the essentially linear dose–response region, for the four‐parameter logistic model. The formulae are expressed in both response and dose units. The derivation of the formulae is shown in order to illustrate the general nature of the methodology. Examples are given that describe how the formulae may be used while planning and conducting bioassays. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献