艾滋病疗法的评价及疗效的预测

根据美国艾滋病医疗实验机构ACTG提供的两组数据,利用二次拟合预测了持续使用这四种艾滋病疗法的效果,并对这些疗法做出了一定的评价。     

对高校电子阅览室数据存储及光碟共享方案的思考

高校图书馆电子阅览室数据存储、光碟共享的现状令人堪忧 ,为解决阅览室光盘共享中的种种问题 ,应采用虚拟光碟镜像服务器方案对阅览室的光盘库、光盘塔进行改革。该方案具有在线并发访问量大、经济实用、便于管理等多种优点     

技术进步计算和经济发展研究中的势分析模型

柯布—道格拉斯生产函数(CD生产函数)是技术进步测算和经济分析的重要函数。势分析理论和方法在CD生产函数的基础上对技术进步指标的测算方法进行了改进,使之能提供更多更合理的有用信息。边际经济参数、全要素生产率和科技进步指标都是经济运行分析中的一些重要经济指标,势分析方法使之和宏观经济发展研究统一起来。     

Using a Box–Cox transformation in the analysis of longitudinal data with incomplete responses

We analyse longitudinal data on CD4 cell counts from patients who participated in clinical trials that compared two therapeutic treatments: zidovudine and didanosine. The investigators were interested in modelling the CD4 cell count as a function of treatment, age at base-line and disease stage at base-line. Serious concerns can be raised about the normality assumption of CD4 cell counts that is implicit in many methods and therefore an analysis may have to start with a transformation. Instead of assuming that we know the transformation (e.g. logarithmic) that makes the outcome normal and linearly related to the covariates, we estimate the transformation, by using maximum likelihood, within the Box–Cox family. There has been considerable work on the Box–Cox transformation for univariate regression models. Here, we discuss the Box–Cox transformation for longitudinal regression models when the outcome can be missing over time, and we also implement a maximization method for the likelihood, assumming that the missing data are missing at random.     

老年慢性心力衰竭患者外周血调节性T细胞的表达

目的探讨老年慢性心力衰竭患者外周血调节性T细胞表达水平及意义。方法采用免疫荧光标记和流式细胞仪技术，对50例老年慢性心力衰竭患者及40例老年健康者的外周血T淋巴细胞亚群表面标记物、不同T细胞亚群、CD4^＋CD25^＋Treg，CD4^＋CD25^＋CD127^-Treg表达进行分析。结果老年慢性心力衰竭患者CD4^＋，CD4^＋/CD8^＋较对照组明显升高（P〈0．05），CD4^＋CD25^＋Treg，CD4^＋CD25^＋CD127^-Treg较对照组显著降低（P〈0．05），缺血性心脏病者与非缺血性心脏病者比较CD4^＋CD25^＋Treg，CD4^＋CD25^＋CD127^-Treg无显著性差异，CHF2组CD4^＋CD25^＋CD127^-Treg显著低于CHF1组（P〈0．05）。结论老年慢性心力衰竭患者外周血调节性T细胞比例显著较少，且与心功能有一定的关系，提示外周免疫耐受功能失常参与老年慢性心力衰竭的发生发展。     

核子中价夸克极化分布函数的OCD标度破坏

本文通过对A-P方程作Mellin变换和对演化函数的Mellin变换结果作展开近似,求得了核子中价夸克极化分布函数随Q~2变化的解析表达式,并利用所得结果给出了核子中夸克自旋不对称量的一些理论预言     

谈随书光盘的管理与利用

针对高校图书馆在随书光盘的管理和利用方面遇到的问题,对随书光盘的特点、管理、加工、服务与利用作了阐述,总结了光盘管理的实践经验,阐述了提高光盘利用率的最佳途径和方法。     

On the assessment of various factors effecting the improvement in CD4 count of aids patients undergoing antiretroviral therapy using generalized Poisson regression

An important marker for identifying the progression of human immunodeficiency virus (HIV) infection in an individual is the CD4 cell count. Antiretroviral therapy (ART) is a treatment for HIV/AIDS (AIDS, acquired immune-deficiency syndrome) which prolongs and improves the lives of patients by improving the CD4 cell count and strengthen the immune system. This strengthening of the immune system in terms of CD4 count, not only depends on various biological factors, but also other behavioral factors. Previous studies have shown the effect of CD4 count on the mortality, but nobody has attempted to study the factors which are likely to influence the improvement in CD4 count of patients diagnosed of AIDS and undergoing ART. In this paper, we use Poisson regression model (GPR) for exploring the effect of various socio-demographic covariates such as age, gender, geographical location, and drug usage on the improvement in the CD4 count of AIDS patients. However, if the CD4 count data suffers from under or overdispersion, we use GPR model and compare it with negative binomial distribution. Finally, the model is applied for the analysis of data on patients undergoing the ART in the Ram Manohar Lohia Hospital, Delhi, India. The data exhibited overdispersion and hence, GPR model provided the best fit.     

面板数据模型的截面相关检验研究

 相关系数的绝对值形式可以很好的避免Pesaran（2004）的CD统计量中异向相关性相互抵消的情况,相应得到一个新的检验面板数据模型扰动项截面相关的统计量。蒙特卡洛模拟显示,无论是在因子模型下还是在空间移动平均模型下,新提出的统计量水平扭曲(size distortion)检验和功效(power)检验表现较好。通过模拟还发现当存在序列相关的扰动项时,先将扰动项进行去序列相关处理可以有效地避免序列相关导致的水平扭曲,并且不会降低统计量的功效。     

深圳和汕头地区经济增长要素贡献的实证比较

地区经济增长差异在扩大一直是经济发展中的一个值得关注的问题。影响地区增长差异的因素是多方面的,包括生产要素、需求条件、相关和支持性产业、企业战略、产业结构、机遇、政府作用等。利用CD生产函数比较汕头与深圳经济长期增长中各要素的贡献率,分析影响两地经济增长差异的要素。