新恢复系绵恢501绵恢502与明恢63主要性状配合力的比较分析

本文通过参试杂交水稻10个性状的方差分析和不育系、恢复系一般配合力、特殊配合力估算及配合力总效应值比较,分析了新恢复系绵恢501、绵恢502与明恢63的异同,结果表明,三个恢复系虽然在多数性状上存在着显著差异,但由于它们各自在产量三要素:穗、粒、重上的性状互补,反应在单株粒重上,三者之间差异甚小,结实率、单株粒重的一般配合力效应值和配合力总效应值,三个恢复系非常按近,表明它们具有相似的恢复力和生产潜力。     

An analytic method for randomized trials with informative censoring: Part 1

Consider a randomized trial in which time to the occurrence of a particular disease, say pneumocystis pneumonia in an AIDS trial or breast cancer in a mammographic screening trial, is the failure time of primary interest. Suppose that time to disease is subject to informative censoring by the minimum of time to death, loss to and end of follow-up. In such a trial, the censoring time is observed for all study subjects, including failures. In the presence of informative censoring, it is not possible to consistently estimate the effect of treatment on time to disease without imposing additional non-identifiable assumptions. The goals of this paper are to specify two non-identifiable assumptions that allow one to test for and estimate an effect of treatment on time to disease in the presence of informative censoring. In a companion paper (Robins, 1995), we provide consistent and reasonably efficient semiparametric estimators for the treatment effect under these assumptions. In this paper we largely restrict attention to testing. We propose tests that, like standard weighted-log-rank tests, are asymptotically distribution-free -level tests under the null hypothesis of no causal effect of treatment on time to disease whenever the censoring and failure distributions are conditionally independent given treatment arm. However, our tests remain asymptotically distribution-free -level tests in the presence of informative censoring provided either of our assumptions are true. In contrast, a weighted log-rank test will be an -level test in the presence of informative censoring only if (1) one of our two non-identifiable assumptions hold, and (2) the distribution of time to censoring is the same in the two treatment arms. We also extend our methods to studies of the effect of a treatment on the evolution over time of the mean of a repeated measures outcome, such as CD-4 count.     

Limit theorems for dependent Bernoulli variables with statistical inference

We consider a class of dependent Bernoulli variables where the conditional success probability is a linear combination of the last few trials and the original success probability. We obtain its limit theorems including the strong law of large numbers, weak invariance principle, and law of the iterated logarithm. We also derive some statistical inference results which make the model applicable. Simulation results are exhibited as well to show that with small sample size the convergence rate is satisfying and the proposed estimators behave well.     

Estimation of nonseparable models with censored dependent variables and endogenous regressors

In this article we develop a nonparametric estimator for the local average response of a censored dependent variable to endogenous regressors in a nonseparable model where the unobservable error term is not restricted to be scalar and where the nonseparable function need not be monotone in the unobservables. We formalize the identification argument put forward in Altonji, Ichimura, and Otsu (2012 Altonji, J. G., Ichimura, H., Otsu, T. (2012). Estimating derivatives in nonseparable models with limited dependent variables. Econometrica 80:1701–1719.[Crossref], [Web of Science ®] , [Google Scholar]), construct a nonparametric estimator, characterize its asymptotic property, and conduct a Monte Carlo investigation to study its small sample properties. Identification is constructive and is achieved through a control function approach. We show that the estimator is consistent and asymptotically normally distributed. The Monte Carlo results are encouraging.     

An integrated model based on statistical process control and maintenance for two-stage dependent processes

The close relationship between quality and maintenance of manufacturing systems has contributed to the development of integrated models which use the concept of statistical process control (SPC) and maintenance. This article demonstrates the integration of the Shewhart individual-residual (Z_X ? Z_e) joint control chart and maintenance for two-stage dependent processes by jointly optimizing their policies to minimize the expected total costs associated with quality, maintenance and inspection. To evaluate the effectiveness of the proposed model, two stand-alone models—a maintenance model and an SPC model—are proposed. Then a numerical example is given to illustrate the application of the proposed integrated model. The results show that the integrated model outperforms the two stand-alone models with regard to the expected cost per unit time. Finally, a sensitivity analysis is conducted to develop insights into time parameters and cost parameters that influence the integration efforts.     

统计显著性:一个被误读的P值——基于美国统计学会的声明

美国统计学会"关于统计显著性与P值"的官方声明发布之后,再次引发国内外研究学者对P值的广泛关注。在介绍国内统计教材中假设检验的基本内容和步骤的基础上,以"硬币投掷"与"背影识人"为例直观性解释P值、统计显著性与统计功效等相关概念,并引用心理学统计经典调查案例分析P值被误读的原因。同时,基于美国统计学会的声明,给出正确使用P值的建议。     

Tactical production and distribution planning with dependency issues on the production process

Tactical production-distribution planning models have attracted a great deal of attention in the past decades. In these models, production and distribution decisions are considered simultaneously such that the combined plans are more advantageous than the plans resolved in a hierarchical planning process. We consider a two-stage production process, where in the first stage raw materials are transformed into continuous resources that feed the discrete production of end products in the second stage. Moreover, the setup times and costs of resources depend on the sequence in which they are processed in the first stage. The minimum scheduling unit is the product family which consists of products sharing common resources and manufacturing processes. Based on different mathematical modelling approaches to the production in the first stage, we develop a sequence-oriented formulation and a product-oriented formulation, and propose decomposition-based heuristics to solve this problem efficiently. By considering these dependencies arising in practical production processes, our model can be applied to various industrial cases, such as the beverage industry or the steel industry. Computation tests on instances from an industrial application are provided at the end of the paper.     

从启蒙者到依附者——“17年诗歌”诗人角色的易换

回望17年诗坛,我们在大多数诗歌千篇一律的声音里发现,那个自"五四"以来就置身于"启蒙"潮头的身影,在三十年后竟然成为政策的传声筒、政治的依附者。社会状况、读者对象、诗歌审美标准、诗人心态的改变,及其病态的"先锋情结",是这代诗人们最终选择"依附者"角色的至关重要的因素。     

Bootstrap methods for bias correction and confidence interval estimation for nonlinear quantile regression of longitudinal data

This paper examines the use of bootstrapping for bias correction and calculation of confidence intervals (CIs) for a weighted nonlinear quantile regression estimator adjusted to the case of longitudinal data. Different weights and types of CIs are used and compared by computer simulation using a logistic growth function and error terms following an AR(1) model. The results indicate that bias correction reduces the bias of a point estimator but fails for CI calculations. A bootstrap percentile method and a normal approximation method perform well for two weights when used without bias correction. Taking both coverage and lengths of CIs into consideration, a non-bias-corrected percentile method with an unweighted estimator performs best.     

Dependency and truncated forms of combinations in multivariate combination-based permutation tests and ordered categorical variables

ABSTRACT

Quite an important problem usually occurs in several multi-dimensional hypotheses testing problems when variables are correlated. In this framework the non-parametric combination (NPC) of a finite number of dependent permutation tests is suitable to cover almost all real situations of practical interest since the dependence relations among partial tests are implicitly captured by the combining procedure itself without the need to specify them [Pesarin F, Salmaso L. Permutation tests for complex data: theory, applications and software. Chichester: Wiley; 2010a]. An open problem related to NPC-based tests is the impact of the dependency structure on combined tests, especially in the presence of categorical variables. This paper’s goal is firstly to investigate the impact of the dependency structure on the possible significance of combined tests in cases of ordered categorical responses using Monte Carlo simulations, then to propose some specific procedures aimed at improving the power of multivariate combination-based permutation tests. The results show that an increasing level of correlation/association among responses negatively affects the power of combination-based multivariate permutation tests. The application of special forms of combination functions based on the truncated product method [Zaykin DV, Zhivotovsky LA, Westfall PH, Weir BS. Truncated product method for combining p-values. Genet Epidemiol. 2002;22:170–185; Dudbridge F, Koeleman BPC. Rank truncated product of p-values, with application to genomewide association scans. Genet Epidemiol. 2003;25:360–366] or on Liptak combination allowed us, using Monte Carlo simulations, to demonstrate the possibility of mitigating the negative effect on power of combination-based multivariate permutation tests produced by an increasing level of correlation/association among responses.