Stratified Case-Cohort Analysis of General Cohort Sampling Designs

Abstract.  It is shown that variance estimates for regression coefficients in exposure-stratified case-cohort studies (Borgan et al ., Lifetime Data Anal., 6, 2000, 39–58) can easily be obtained from influence terms routinely calculated in the standard software for Cox regression. By allowing for post-stratification on outcome we also place the estimators proposed by Chen ( J. R. Statist. Soc. Ser. B , 63, 2001, 791–809) for a general class of cohort sampling designs within the Borgan et al. 's framework, facilitating simple variance estimation for these designs. Finally, the Chen approach is extended to accommodate stratified designs with surrogate variables available for all cohort members, such as stratified case-cohort and counter-matching designs.     

DELETE-2 AND DELETE-3 JACKKNIFE PROCEDURES FOR UNMASKING IN REGRESSION

Single-case deletion regression diagnostics have been used widely to discover unusual data points, but such approaches can fail in the presence of multiple unusual data points and as a result of masking. We propose a new approach to the use of single-case deletion diagnostics that involves applying these diagnostics to delete-2 and delete-3 jackknife replicates of the data, and considering the percentage of times among these replicates that points are flagged as unusual as an indicator of their influence. By considering replicates that exclude certain collections of points, subtle masking effects can be uncovered.     

Regression Diagnostic under Model Misspecification

We propose two novel diagnostic measures for the detection of influential observations for regression parameters in linear regression. Traditional diagnostic statistics focus on the effect of deletion of data points either on parameter estimates, or on predicted values. A data point is regarded as influential by the new methods if its inclusion determines a significantly different likelihood function for the parameter of interest. The concerned likelihood function is asymptotically valid for practically all underlying distributions whose second moments exist.